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dc.contributor.authorIsmael, Aya
dc.contributor.authorGevorgyan, Ashot
dc.contributor.authorSkrydstrup, Troels
dc.contributor.authorBayer, Annette
dc.date.accessioned2021-04-26T08:17:59Z
dc.date.available2021-04-26T08:17:59Z
dc.date.issued2020-09-04
dc.description.abstractSolvents constitute the largest component for many chemical processes and substitution of nonrenewable solvents is a longstanding goal for green chemistry. Here, we show that Pd-catalyzed carbonylative couplings, such as carbonylative cross-couplings, aminocarbonylations, and alkoxycarbonylations, can be successfully realized using renewable solvents. The present research covers not only well-established renewable solvents, such as 2-methyltetrahydrofuran (2MeTHF), limonene, and dimethyl carbonate, but also recently introduced biomass-derived 1,1-diethoxyethane, isosorbide dimethyl ether, eucalyptol, rose oxide, γ-terpinene, and α-pinene. The carbonylative coupling of boronic acids and aryl bromides works well in limonene. Aminocarbonylation gave excellent results in dimethyl carbonate, α-pinene, and limonene, while alkoxycarbonylation was successful in 2MeTHF, α-pinene, γ-terpinene, and dimethyl carbonate. The developed methods based on renewable solvents can be used for the synthesis of commercial drug Trimetozine and an analogue of Itopride.en_US
dc.identifier.citationIsmael A, Gevorgyan A, Skrydstrup T, Bayer A. Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions. Organic Process Research & Development. 2020en_US
dc.identifier.cristinIDFRIDAID 1827514
dc.identifier.doihttp://dx.doi.org/10.1021/acs.oprd.0c00325
dc.identifier.issn1083-6160
dc.identifier.issn1520-586X
dc.identifier.urihttps://hdl.handle.net/10037/21045
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.journalOrganic Process Research & Development
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.titleRenewable Solvents for Palladium-Catalyzed Carbonylation Reactionsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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