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dc.contributor.authorAverina, Maria
dc.contributor.authorBrox, Jan
dc.contributor.authorHuber, Sandra
dc.contributor.authorFurberg, Anne-Sofie
dc.date.accessioned2021-06-16T11:15:32Z
dc.date.available2021-06-16T11:15:32Z
dc.date.issued2021-01-15
dc.description.abstractBackground - Prevalence of obesity, hypertension and dyslipidemia has been increasing in children and adolescents worldwide. Exposure to environmental pollutants may contribute to this development. Our aim was to study associations between perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in a population-based sample of adolescents. <p> <p>Methods - Serum PFAS concentrations were measured in 940 adolescents, mean age 16.4 (SD 1.3) years, from the cross-sectional Fit Futures study by the UHPLC-MS/MS method. The following endpoints were used: hypertension (systolic blood pressure over 130 mmHg and/or diastolic blood pressure over 80 mmHg); obesity (body mass index over 2 z-score, WHO charts for adolescents); dyslipidemia (total cholesterol ≥ 5.17 mmol/L, and/or LDL-cholesterol ≥ 3.36 mmol/l, and/or apolipoprotein B ≥ 1.10 g/L). <p> <p>Results - Perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), perfluorodecanoate (PFDA) and perfluoroundecanoate (PFUnDA) serum concentrations were positively associated with apolipoprotein B, total- and LDL cholesterol. The highest vs. lowest quartiles of total PFAS (∑PFAS), PFNA and PFDA concentrations were positively associated with the risk of dyslipidemia: OR 2.24 (95% CI 1.10-4.54), OR 2.30 (95% CI 1.16-4.57) and 2.36 (95% CI 1.08-5.16), respectively. The highest vs. lowest quartiles of ∑PFAS, perfluorohexane sulfonate (PFHxS), PFOS, perfluorooctanoate (PFOA) concentrations were positively associated with the risk of hypertension: OR 1.91 (95% CI 1.12-3.26), OR 2.06 (95% CI 1.16-3.65), 1.86 (95% CI 1.08-3.19) and 2.08 (95% CI 1.17-3.69) respectively. PFHxS and perfluoroheptane sulfonate (PFHpS) concentrations were positively associated with obesity. <p> <p>Conclusions - This cross-sectional study showed a possible link between several PFAS and dyslipidemia, hypertension and obesity in Norwegian adolescents.en_US
dc.identifier.citationAverina M, Brox J, Huber SH, Furberg A-S. Exposure to perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in adolescents : the Fit Futures study. Environmental Research. 2021;195(April):1-8en_US
dc.identifier.cristinIDFRIDAID 1875323
dc.identifier.doi10.1016/j.envres.2021.110740
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.urihttps://hdl.handle.net/10037/21456
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEnvironmental Research
dc.relation.projectIDUiT Norges arktiske universitet: 2047661en_US
dc.relation.urihttps://doi.org/10.1016/j.envres.2021.110740
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleExposure to perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in adolescents : the Fit Futures studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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