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dc.contributor.authorRey, Sonia
dc.contributor.authorJin, Xingkun
dc.contributor.authorDamsgård, Børge
dc.contributor.authorBégout, Marie-Laure
dc.contributor.authorMacKenzie, Simon
dc.date.accessioned2021-06-22T09:40:09Z
dc.date.available2021-06-22T09:40:09Z
dc.date.issued2021-01-07
dc.description.abstract<p>Background: Consistent individual differences in behaviour, known as animal personalities, have been demonstrated within and across species. In fish, studies applying an animal personality approach have been used to resolve variation in physiological and molecular data suggesting a linkage, genotype-phenotype, between behaviour and transcriptome regulation. In this study, using three fish species (zebrafish; Danio rerio, Atlantic salmon; Salmo salar and European sea bass; Dicentrarchus labrax), we firstly address whether personality-specific mRNA transcript abundances are transferrable across distantly-related fish species and secondly whether a proactive transcriptome signature is conserved across all three species. <p>Results: Previous zebrafish transcriptome data was used as a foundation to produce a curated list of mRNA transcripts related to animal personality across all three species. mRNA transcript copy numbers for selected gene targets show that differential mRNA transcript abundance in the brain appears to be partially conserved across species relative to personality type. Secondly, we performed RNA-Seq using whole brains from S. salar and D. labrax scoring positively for both behavioural and molecular assays for proactive behaviour. We further enriched this dataset by incorporating a zebrafish brain transcriptome dataset specific to the proactive phenotype. Our results indicate that cross-species molecular signatures related to proactive behaviour are functionally conserved where shared functional pathways suggest that evolutionary convergence may be more important than individual mRNAs. <p>Conclusions: Our data supports the proposition that highly polygenic clusters of genes, with small additive effects, likely support the underpinning molecular variation related to the animal personalities in the fish used in this study. The polygenic nature of the proactive brain transcriptome across all three species questions the existence of specific molecular signatures for proactive behaviour, at least at the granularity of specific regulatory gene modules, level of genes, gene networks and molecular functions.en_US
dc.identifier.citationRey, Jin, Damsgård, Bégout, MacKenzie. Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour. BMC Genomics. 2021;22en_US
dc.identifier.cristinIDFRIDAID 1904618
dc.identifier.doi10.1186/s12864-020-07317-z
dc.identifier.issn1471-2164
dc.identifier.urihttps://hdl.handle.net/10037/21515
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBMC Genomics
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/265957/EU/A new integrative framework for the study of fish welfare based on the concepts of allostasis, appraisal and coping styles/COPEWELL/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecology: 488en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økologi: 488en_US
dc.titleAnalysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviouren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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