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dc.contributor.authorRognli, Eline B.
dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorvon Soest, Tilmann
dc.date.accessioned2021-06-24T09:03:25Z
dc.date.available2021-06-24T09:03:25Z
dc.date.issued2021-02-15
dc.description.abstract<i>Background</i> - Whether smoking should be regarded as a risk factor for mental disorders remains unresolved. Prescribed psychotropic drugs can be used as indications for mental disorders. We investigated how smoking was prospectively related to prescription of antipsychotics, mood stabilizers, antidepressants, and anxiolytics.<br><br> <i>Methods</i> - Information about smoking, including the Fagerström Test for Nicotine Dependence, and relevant confounders, were obtained from the population-based Young in Norway Study (<i>N</i> = 2602), with four data collection waves between 1992 and 2006. These survey data were linked with information on prescriptions for psychotropic drugs from the comprehensive, nationwide Norwegian Prescription Database from 2007 to 2015.<br><br> <i>Results</i> - Daily smoking with high dependence in 2006 at age 28.5 (s.d. = 2.0) was associated with filling prescriptions of antipsychotics (OR, 6.57, 95% CI 2.19–19.70, <i>p</i> = 0.001), mood stabilizers (OR, 7.11, 95% CI 2.51–20.15, <i>p</i> < 0.001) and antidepressants (OR, 1.91, 95% CI 1.13–3.23, <i>p</i> = 0.016) 1–9 years later. Associations remained significant after adjustment for a variety of potential confounders measured before the assessment of smoking, including sociodemographic background, conduct problems, cannabis use, mental distress, and previous prescriptions for psychotropic medications. The association between smoking and prescription of anxiolytics was weaker and more unstable.<br><br> <i>Conclusions</i> - In this study of young adults, daily smoking with high dependence was associated with later prescriptions of antipsychotics, mood stabilizers and antidepressants, indicating smoking as a risk factor for mental disorders treated with these drugs.en_US
dc.identifier.citationRognli EB, Bramness JG, von Soest TvS. Smoking in early adulthood is prospectively associated with prescriptions of antipsychotics, mood stabilizers, antidepressantsand anxiolytics. Psychological Medicine. 2021:1-10en_US
dc.identifier.cristinIDFRIDAID 1899902
dc.identifier.doi10.1017/S0033291720005401
dc.identifier.issn0033-2917
dc.identifier.issn1469-8978
dc.identifier.urihttps://hdl.handle.net/10037/21551
dc.language.isoengen_US
dc.publisherCambridge University Pressen_US
dc.relation.journalPsychological Medicine
dc.relation.projectIDNorges forskningsråd: 301010en_US
dc.relation.projectIDNorges forskningsråd: 288083en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/VAM-Velferd/301010/Norway/Pathways into Marginalization. A 28-Year Longitudinal Study from Adolescence to Middle Adulthood//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEDREHELSE/288083/Norway/Research Center for Developmental Processes and Gradients in Mental Health/PROMENTA/en_US
dc.relation.urihttps://www.cambridge.org/core/journals/psychological-medicine/article/smoking-in-early-adulthood-is-prospectively-associated-with-prescriptions-of-antipsychotics-mood-stabilizers-antidepressants-and-
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleSmoking in early adulthood is prospectively associated with prescriptions of antipsychotics, mood stabilizers, antidepressantsand anxiolyticsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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