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dc.contributor.authorSundnes, Olav
dc.contributor.authorOttestad, William Arne
dc.contributor.authorSchjalm, Camilla
dc.contributor.authorLundbäck, Peter
dc.contributor.authorLa Cour Poulsen, Lars
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorHaraldsen, Guttorm
dc.contributor.authorEken, Torsten
dc.date.accessioned2021-06-28T11:42:37Z
dc.date.available2021-06-28T11:42:37Z
dc.date.issued2021-03-26
dc.description.abstractBackground - Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma.<p> <p>Methods - Plasma samples were serially collected from 136 trauma patients immediately after hospital admission, 2, 4, 6, and 8 h thereafter, and every morning in the ICU. Levels of IL-33 and its decoy receptor sST2 were measured by immunoassays.<p> <p>Results - We observed a rapid and transient surge of IL-33 in a subset of critically injured patients. These patients had more widespread tissue injuries and a greater degree of early coagulopathy. IL-33 half-life (t1/2) was 1.4 h (95% CI 1.2–1.6). sST2 displayed a distinctly different pattern with low initial levels but massive increase at later time points.<p> <p>Conclusions - We describe for the first time early high-resolution IL-33 concentration kinetics in individual patients after trauma and correlate systemic IL-33 release to clinical data. These findings provide insight into a potentially important axis of danger signaling in humans.en_US
dc.identifier.citationSundnes, Ottestad, Schjalm, Lundbäck, La Cour Poulsen, Mollnes, Haraldsen, Eken. Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study. Molecular medicine (Cambridge, Mass. Print). 2021;27en_US
dc.identifier.cristinIDFRIDAID 1916736
dc.identifier.doi10.1186/s10020-021-00288-1
dc.identifier.issn1076-1551
dc.identifier.issn1528-3658
dc.identifier.urihttps://hdl.handle.net/10037/21581
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalMolecular medicine (Cambridge, Mass. Print)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleRapid systemic surge of IL-33 after severe human trauma: a prospective observational studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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