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dc.contributor.authorPliatsikas, Christos
dc.contributor.authorPereira Soares, Sergio Miguel
dc.contributor.authorVoits, Toms
dc.contributor.authorDeLuca, Vincent
dc.contributor.authorRothman, Jason
dc.date.accessioned2021-07-13T08:48:20Z
dc.date.available2021-07-13T08:48:20Z
dc.date.issued2021-03-29
dc.description.abstractCognitively demanding experiences, including complex skills acquisition and processing, have been shown to induce brain adaptations, at least at the macroscopic level, e.g. on brain volume and/or functional connectivity. However, the neurobiological bases of these adaptations, including at the cellular level, are unclear and understudied. Here we use bilingualism as a case study to investigate the metabolic correlates of experience-based brain adaptations. We employ Magnetic Resonance Spectroscopy to measure metabolite concentrations in the basal ganglia, a region critical to language control and reshaped by bilingualism. Our results show increased myo-Inositol and decreased N-acetyl aspartate concentrations in bilinguals compared to monolinguals. Both metabolites are linked to synaptic pruning, a process underlying experience-based brain restructuring. Interestingly, both concentrations correlate with relative amount of bilingual engagement. This suggests that degree of long-term cognitive experiences matters at the level of metabolic concentrations, which might accompany, if not drive, macroscopic brain adaptations.en_US
dc.identifier.citationPliatsikas C, Pereira Soares SM, Voits T, DeLuca V, Rothman J. Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain. Scientific Reports. 2021en_US
dc.identifier.cristinIDFRIDAID 1898404
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/21867
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.relation.projectIDUiT Norges arktiske universitet: 2062165en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/765556/EU/The Multilingual Mind/MultiMind/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Humanities: 000::Linguistics: 010en_US
dc.subjectVDP::Humaniora: 000::Språkvitenskapelige fag: 010en_US
dc.titleBilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brainen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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