Blar i tittel Mastergradsoppgaver i kjemi

Viser treff 49-54 av 54

    • Synthesis of thiol-appended gold and rhenium corroles as potential nanoconjugants for gold nanoparticles 

      Engedal Johannessen, Krister (Master thesis; Mastergradsoppgave, 2023-06-10)
      Photodynamic therapy (PDT) today is an established treatment for a variety of cancers as well as various dermatological conditions, macular degeneration and bacterial and other infections. Treatment involves the administration of a photosensitizer, typically a porphyrin, followed by irradiation with light. The photoexcited sensitizer transfers its excess energy to oxygen in the affected tissue, ...

    • Synthesis of XTH inhibitors 

      Pettersen, Martin (Master thesis; Mastergradsoppgave, 2019-05-15)
      XTH er en gruppe enzymer som ble oppdaget tidlig på 90 tallet og muligens er involvert i Cuscuta infeksjonen av tomater. En nylig studie gjort ved arktisk og marin biologi UIT viser at Brilliant Blue R250 fungerer som en god inhibitor mot disse enzymene. I dette prosjektet ble det fokusert på å syntetisere strukturelt like molekyler for å potensielt øke vannløseligheten og inhibitoraktiviteten. ...

    • Synthesis of β-substituted β-aminoboronates 

      Thomassen, Ivar Kristian (Master thesis; Mastergradsoppgave, 2013-05)
      Recent work at the University of Tromsø has uncovered new α-substituted α- and β-aminoboron containing peptidomimetics that shows antimicrobial, antifungal and antitubercular activity in addition to kinase inhibition and promotion. As a continuation of this work a new approach for the synthesis of β-substituted β-aminoboronates has been developed. The approach involves the non-stereospecific ...

    • Target characterization and ligand design directed at deoxyuridine 5'-triphospate nucleotidohydrolase 

      Liikanen, Laura Elina (Master thesis; Mastergradsoppgave, 2014-07-01)
      dUTPase is an important enzyme in DNA metabolism. It can be thought of as a gate keeper for apoptosis and is therefore an attractive target when trying to kill malign cells which cause disease in the human body. dUTPase has been found to be an important drug target in diseases such as cancer and malaria, to mention two. Due to problems with drug resistance in existing treatments, the search for new ...

    • The unique disulfide linked activation loop of DYRK kinases and possible redox activity control 

      Dyrendalsli, Maja Bele (Master thesis; Mastergradsoppgave, 2022-06-15)
      The cysteine of HCD (C286) in DYRK1A is involved in disulfide bridge formation with a cysteine (C312) in the DFGSSC sequence. The purpose of this project was to investigate how the state of the disulfide bridge would affect enzyme catalytic and ligand binding properties of the protein kinase. A mutant, DYRK1A C312A, was thus designed to eliminate the disulfide bridge. The mutant was expressed and ...

    • Vertical Diversity-Oriented Synthesis with Dibenzylideneacetones. Multivariate Optimization and Diversity Exploration. 

      Buhire, Phenias (Master thesis; Mastergradsoppgave, 2015-05-18)
      DOS was planned from dibenzylideneacetone to generate compound library with structural diversity, which can undergo further transformations. In the presented work, dibenzylideneacetone was cyclized under Robinson Annulation reaction. The resulting cyclization product was optimized using Multivariate response surface method. Response surface analysis helped to determine both significant variables ...