• Target characterization and ligand design directed at deoxyuridine 5'-triphospate nucleotidohydrolase 

      Liikanen, Laura Elina (Master thesis; Mastergradsoppgave, 2014-07-01)
      dUTPase is an important enzyme in DNA metabolism. It can be thought of as a gate keeper for apoptosis and is therefore an attractive target when trying to kill malign cells which cause disease in the human body. dUTPase has been found to be an important drug target in diseases such as cancer and malaria, to mention two. Due to problems with drug resistance in existing treatments, the search for new ...