Blar i forfatter Mastergradsoppgaver i kjemi "Dyrendalsli, Maja Bele"

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    • The unique disulfide linked activation loop of DYRK kinases and possible redox activity control 

      Dyrendalsli, Maja Bele (Master thesis; Mastergradsoppgave, 2022-06-15)
      The cysteine of HCD (C286) in DYRK1A is involved in disulfide bridge formation with a cysteine (C312) in the DFGSSC sequence. The purpose of this project was to investigate how the state of the disulfide bridge would affect enzyme catalytic and ligand binding properties of the protein kinase. A mutant, DYRK1A C312A, was thus designed to eliminate the disulfide bridge. The mutant was expressed and ...