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dc.contributor.authorNæss, Marit
dc.contributor.authorSund, Erik
dc.contributor.authorVie, Gunnhild Åberge
dc.contributor.authorBjørngaard, Johan Håkon
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorHolmen, Turid Lingaas
dc.contributor.authorKvaløy, Kirsti
dc.date.accessioned2021-11-15T09:34:38Z
dc.date.available2021-11-15T09:34:38Z
dc.date.issued2021-10-14
dc.description.abstractObjective - This study examined the relationship between parental obesity polygenic risk and children’s BMI throughout adolescence. Additionally, from a smaller subsample, the objective was to assess whether parental polygenic risk score (PRS) may act as a proxy for offspring PRS in studies lacking offspring genetic data.<p> <p>Methods - A total of 8,561 parent-offspring (age 13-19 years) trios from the Trøndelag Health Study (the HUNT Study) were included, of which, 1,286 adolescents had available genetic data. Weighted parental PRSs from 900 single-nucleotide polymorphisms robustly associated with adult BMI were constructed and applied in linear mixed-effects models.<p> <p>Results - A positive association between parental PRS and offspring sex- and age-adjusted BMI (iso-BMI) throughout adolescence was identified. The estimated marginal effects per standard deviation increase in parental PRS were 0.26 (95% CI: 0.18-0.33), 0.36 (95% CI: 0.29-0.43), and 0.62 kg/m2 (95% CI: 0.51-0.72) for maternal, paternal, and combined parental PRS, respectively. In subsample analyses, the magnitude of association of the parental PRS versus offspring PRS with iso-BMI in adolescents was similar.<p> <p>Conclusions - Parental PRS was consistently associated with offspring iso-BMI throughout adolescence. Results from subsample analyses support the use of parental PRS of obesity as a proxy for adolescent PRS in the absence of offspring genetic data.en_US
dc.identifier.citationNæss MN, Sund E, Vie GÅ, Bjørngaard JHB, Åsvold BO, Holmen T, Kvaløy K. Intergenerational polygenic obesity risk throughout adolescence in a cross-sectional study design: The HUNT study, Norway. Obesity. 2021en_US
dc.identifier.cristinIDFRIDAID 1946111
dc.identifier.doi10.1002/oby.23284
dc.identifier.issn1930-7381
dc.identifier.issn1930-739X
dc.identifier.urihttps://hdl.handle.net/10037/22988
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalObesity
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/?/Norway/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleIntergenerational polygenic obesity risk throughout adolescence in a cross-sectional study design: The HUNT study, Norwayen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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