| dc.description.popularabstract | Localized drug action is expected to improve therapeutic outcome of many diseases, including skin therapy. The optimization of nanocarriers that can carry the drug into the targeted skin layers in a controllable manner leads to improvement in therapy. In this PhD project, different lipid nanoparticles were tested as nanocarriers on the skin model developed to closely mimic the living human skin. Elastic spherical vesicles, deformable liposomes, were found to be the most promising nanocarriers delivering the active compounds in the deeper skin layers while avoiding systemic absorption. By exploring the effect of vesicle surface charge, a sustained dermal delivery of the active substances was achieved and their biological activities, such as anti-inflammatory and anti-bacterial, enhanced. Positively charged deformable liposomes in chitosan hydrogel were proposed as advanced wound dressing able to assure prolonged drug localization at the administration site. | en_US |
| dc.relation.haspart | <p>Paper I: Ternullo, S., de Weerd, L., Flaten, G.E., Holsæter, A.M. & Škalko‐Basnet, N. (2017). The isolated perfused human skin flap model: A missing link in skin penetration studies? <i>European Journal of Pharmaceutical Sciences, 96</i>, 334-341. Also available at <a href=https://doi.org/10.1016/j.ejps.2016.10.003>https://doi.org/10.1016/j.ejps.2016.10.003</a>.
<p>Paper II: Ternullo, S., de Weerd, L., Holsæter, A.M., Flaten, G.E. & Škalko-Basnet, N. (2017). Going skin deep: A direct comparison of penetration potential of lipid‐based nanovesicles on the isolated perfused human skin flap model. <i>European Journal of Pharmaceutics and Biopharmaceutics, 121</i>, 14-23. Also available at <a href= https://doi.org/10.1016/j.ejpb.2017.09.006> https://doi.org/10.1016/j.ejpb.2017.09.006</a>.
<p>Paper III: Ternullo, S., Basnet, P., Holsæter, A.M., Flaten, G.E., de Weerd, L. & Škalko‐Basnet, N. Deformable liposomes for dermal delivery of human epidermal growth factor: The effect of liposomal surface charge. (Manuscript). Now published in <i>European Journal of Pharmaceutical Sciences, 125</i>, 163-171, available at <a href=https://doi.org/10.1016/j.ejps.2018.10.005>https://doi.org/10.1016/j.ejps.2018.10.005</a>.
<p>Paper IV: Ternullo, S., Gagnat, E., Julin, K., Johannessen, M., Basnet, P., Vanić, Ž. & Škalko‐Basnet, N. Nanocarriers for dermal delivery: The carrier surface charge affects biological activities of curcumin. (Manuscript). Now published as: Liposomes augment biological benefits of curcumin for multitargeted skin therapy. <i>European Journal of Pharmaceutics and Biopharmaceutics, 144</i>, 2019, 154-164, available at <a href=https://doi.org/10.1016/j.ejpb.2019.09.016>https://doi.org/10.1016/j.ejpb.2019.09.016</a>.
<p>Paper V: Ternullo, S., Schulte‐Werning, L.V. & Škalko‐Basnet, N. Curcumin‐in‐deformable liposomes‐in‐hydrogel: The effect of liposomal surface charge on dermal delivery of curcumin. (Manuscript). Now published as Ternullo, S., Schulte‐Werning, L.V., Holsæter, A.M. & Škalko‐Basnet, N. (2020). Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing. <i>Pharmaceutics, 2020, 12</i>(1), 8, available at <a href=https://doi.org/10.3390/pharmaceutics12010008>https://doi.org/10.3390/pharmaceutics12010008</a>. | en_US |
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