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dc.contributor.authorMarcks, Nick
dc.contributor.authorAimo, Alberto
dc.contributor.authorJanuzzi, James L.
dc.contributor.authorVergaro, Giuseppe
dc.contributor.authorClerico, Aldo
dc.contributor.authorLatini, Roberto
dc.contributor.authorMeessen, Jennifer
dc.contributor.authorAnand, Inder S.
dc.contributor.authorCohn, Jay N.
dc.contributor.authorGravning, Jørgen
dc.contributor.authorUeland, Thor
dc.contributor.authorBayes-Genis, Antoni
dc.contributor.authorLupón, Josep
dc.contributor.authorde Boer, Rudolf A.
dc.contributor.authorYoshihisa, Akiomi
dc.contributor.authorTakeishi, Yasuchika
dc.contributor.authorEgstrup, Michael
dc.contributor.authorGustafsson, Ida
dc.contributor.authorGaggin, Hanna K.
dc.contributor.authorEggers, Kai M.
dc.contributor.authorHuber, Kurt
dc.contributor.authorTentzeris, Ioannis
dc.contributor.authorRipoli, Andrea
dc.contributor.authorPassino, Claudio
dc.contributor.authorSanders-van Wijk, Sandra
dc.contributor.authorEmdin, Michele
dc.contributor.authorBrunner-La Rocca, Hans-Peter
dc.date.accessioned2022-01-25T13:35:39Z
dc.date.available2022-01-25T13:35:39Z
dc.date.issued2021-03-11
dc.description.abstractBackground - Higher body mass index (BMI) is associated with better outcome compared with normal weight in patients with HF and other chronic diseases. It remains uncertain whether the apparent protective role of obesity relates to the absence of comorbidities. Therefore, we investigated the effect of BMI on outcome in younger patients without co-morbidities as compared to older patients with co-morbidities in a large heart failure (HF) population.<p> <p>Methods - In an individual patient data analysis from pooled cohorts, 5,819 patients with chronic HF and data available on BMI, co-morbidities and outcome were analysed. Patients were divided into four groups based on BMI (i.e. ≤ 18.5 kg/m2, 18.5–25.0 kg/m2; 25.0–30.0 kg/m2; 30.0 kg/m2). Primary endpoints included all-cause mortality and HF hospitalization-free survival.<p> <p>Results - Mean age was 65 ± 12 years, with a majority of males (78%), ischaemic HF and HF with reduced ejection fraction. Frequency of all-cause mortality or HF hospitalization was significantly worse in the lowest two BMI groups as compared to the other two groups; however, this effect was only seen in patients older than 75 years or having at least one relevant co-morbidity, and not in younger patients with HF only. After including medications and N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin concentrations into the model, the prognostic impact of BMI was largely absent even in the elderly group with co-morbidity.<p> <p>Conclusions - The present study suggests that obesity is a marker of less advanced disease, but does not have an independent protective effect in patients with chronic HF.en_US
dc.identifier.citationMarcks, Aimo, Januzzi, Vergaro, Clerico, Latini, Meessen, Anand, Cohn, Gravning, Ueland, Bayes-Genis, Lupón, de Boer, Yoshihisa, Takeishi, Egstrup, Gustafsson, Gaggin, Eggers, Huber, Tentzeris, Ripoli, Passino, Sanders-van Wijk, Emdin, Brunner-La Rocca. Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data. Clinical Research in Cardiology. 2021;110(8):1280-1291en_US
dc.identifier.cristinIDFRIDAID 1987931
dc.identifier.doi10.1007/s00392-021-01822-1
dc.identifier.issn1861-0684
dc.identifier.issn1861-0692
dc.identifier.urihttps://hdl.handle.net/10037/23801
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalClinical Research in Cardiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleRe-appraisal of the obesity paradox in heart failure: a meta-analysis of individual dataen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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