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Validation of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma-molGPA).

Permanent lenke
https://hdl.handle.net/10037/24880
DOI
https://doi.org/10.14740/jocmr3248w
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article.pdf (524.2Kb)
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Dato
2018-03
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Nieder, Carsten; Hintz, Mandy; Bilger, Angelika; Oehlke, Oliver; Grosu, Anca L.
Sammendrag
Background: It has been suggested to replace the diagnosis-specific graded prognostic assessment (DS-GPA, based on performance status and number of brain metastases) for patients with primary malignant melanoma with the new Melanoma-molGPA. The latter is a more complex assessment, which also includes BRAF mutation status, age and extracranial metastases. To test the performance of the Melanoma-molGPA, we performed a validation study of this new survival prediction tool.

Methods: A retrospective analysis of patients treated at two different academic institutions was performed. The four-tiered MelanomamolGPA was calculated as suggested in the original study.

Results: Median overall survival was 5.4 months (95% confidence interval: 3.1 - 7.7 months). Median survival in the four prognostic classes was 2.1, 7.8, 11.8, and 18.0 months, respectively. The 1-year survival rates were 3%, 25%, 43%, and 80%, respectively. The difference between the Kaplan-Meier curves was significant (P = 0.0001, log-rank test).

Conclusions: The present survival outcomes support the use of the Melanoma-molGPA. However, survival was better in each of the four groups in the original study. Possible reasons include lead-time bias and different treatment policies.

Forlag
Elmer Press
Sitering
Nieder C, Hintz M, Bilger A, Oehlke O, Grosu AL. Validation of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma-molGPA).. Journal of Clinical Medicine Research. 2018;10(3):178-181
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Copyright 2018 The Author(s)

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