ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraakEnglish 
    • EnglishEnglish
    • norsknorsk
  • Administration/UB
View Item 
  •   Home
  • Universitetsbiblioteket
  • Artikler, rapporter og annet (UB)
  • View Item
  •   Home
  • Universitetsbiblioteket
  • Artikler, rapporter og annet (UB)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Alcohol consumption and lower risk of cardiovascular and all-cause mortality: the impact of accounting for familial factors in twins

Permanent link
https://hdl.handle.net/10037/25605
DOI
https://doi.org/10.1017/S0033291722000812
Thumbnail
View/Open
article.pdf (344.0Kb)
Published version (PDF)
Date
2022-04-20
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Ystrøm, Eivind; Degerud, Eirik Magnus Meek; Tesli, Martin Steen; Høye, Anne; Reichborn-Kjennerud, Ted; Næss, Øyvind Erik
Abstract
Background. A moderate to high alcohol consumption is associated with a lower risk of cardiovascular disease (CVD) mortality in comparison with low consumption. The mechanisms underlying this association are not clear and have been suggested to be caused by residual confounding. The main objective of this study was to separate the familial and individual risk for CVD mortality and all-cause mortality related to alcohol consumption. This will be done by estimating the risk for CVD mortality and all-cause mortality in twin pairs discordant for alcohol consumption.

Methods. Alcohol consumption was assessed at two time points using self-report questionnaires in the Norwegian Twin Registry. Data on CVD mortality was obtained from the Norwegian Cause of Death Registry. Exposure–outcome associations for all-cause mortality and mortality due to other causes than CVD were estimated for comparison.

Results. Coming from a family with moderate to high alcohol consumption was protective against cardiovascular death (HR = 0.54, 95% CI 0.65–0.83). Moderate and high alcohol consumption levels were associated with a slightly increased risk of CVD mortality at the individual level (HR = 1.33, 95% CI 1.02–1.73). There was no association between alcohol consumption and all-cause mortality both at the familial nor at the individual level.

Conclusions. The protective association of moderate to high alcohol consumption with a lower risk of CVD mortality was accounted for by familial factors in this study of twins. Early life genetic and environmental familial factors may mask an absence of health effect of moderate to high alcohol consumption on cardiovascular mortality.

Publisher
Cambridge University Press
Citation
Ystrøm E, Degerud EM, Tesli MS, Høye A, Reichborn-Kjennerud T, Næss Ø. Alcohol consumption and lower risk of cardiovascular and all-cause mortality: the impact of accounting for familial factors in twins. Psychological Medicine. 2022
Metadata
Show full item record
Collections
  • Artikler, rapporter og annet (UB) [3245]
Copyright 2022 The Author(s)

Browse

Browse all of MuninCommunities & CollectionsAuthor listTitlesBy Issue DateBrowse this CollectionAuthor listTitlesBy Issue Date
Login

Statistics

View Usage Statistics
UiT

Munin is powered by DSpace

UiT The Arctic University of Norway
The University Library
uit.no/ub - munin@ub.uit.no

Accessibility statement (Norwegian only)