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Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics

dc.contributor.advisorJohanna U., Ericson
dc.contributor.authorJuskewitz, Eric
dc.date.accessioned2022-08-02T11:37:29Z
dc.date.available2022-08-02T11:37:29Z
dc.date.issued2022-08-12
dc.description.abstractInfections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-resistant bacteria. There is an obvious need for developing new antimicrobials. Natural environments, like the Arctic Ocean, offer largely underexplored biodiversity with promising natural antimicrobial products. This thesis investigates marine and marine-inspired molecules for their antibacterial properties and potential applications.en_US
dc.description.doctoraltypeph.d.en_US
dc.description.popularabstractInfections caused by bacteria are the third leading cause of death worldwide. Antimicrobials are used to treat and prevent those infections and enabled the development of the modern healthcare system as we know it. However, those achievements are threatened by the global emergence of antimicrobial-resistant bacteria. There is an obvious need for developing new antimicrobials. Natural environments, like the Arctic Ocean, offer largely underexplored biodiversity with promising natural antimicrobial products. This thesis investigates marine and marine-inspired molecules for their antibacterial properties and potential applications.en_US
dc.description.sponsorshipThe Research Council of Norway (RCN) grant no. 269425en_US
dc.identifier.urihttps://hdl.handle.net/10037/25912
dc.language.isoengen_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.relation.haspart<p>Paper I: Jenssen, M., Rainsford, P., Juskewitz, E., Andersen, J.H., Hansen, E.H., Isaksson, J., Rämä, T. & Hansen, K.Ø. (2021). Lulworthinone, a new dimeric naphthopyrone from a marine fungus in the family Lulworthiaceae with antibacterial activity against clinical methicillin-resistant <i>Staphylococcus aureus</i> isolates. <i>Frontiers in Microbiology, 12</i>, 2862. Also available in Munin at <a href=https://hdl.handle.net/10037/22945>https://hdl.handle.net/10037/22945</a>. <p>Paper II: Juskewitz, E., Mishchenko, E., Dubey, V.K., Jenssen, M., Jakubec, M., Rainsford, P., … Ericson, J.U. (2022). Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric, naphthopyrone isolated from a marine fungus. <i>Marine Drugs, 20</i>(5), 277. Also available in Munin at <a href=https://hdl.handle.net/10037/25925>https://hdl.handle.net/10037/25925</a>. <p>Paper III: Paulsen, M.H., Engqvist, M., Ausbacher, D., Anderssen, T., Langer, M.K., Haug, T., Morello, G.R., Liikanen, L.E., Blencke, H.M., Isaksson, J., Juskewitz, E., Bayer, A. & Strøm, M.B. (2021). Amphipathic barbiturates as mimics of antimicrobial peptides and the marine natural products eusynstyelamides with activity against multi-resistant clinical isolates. <i>Journal of Medicinal Chemistry, 64</i>(15), 11395–11417. Also available in Munin at <a href=https://hdl.handle.net/10037/22150>https://hdl.handle.net/10037/22150</a>. <p>Paper IV: Karlsen, E.A., Stensen, W., Juskewitz, E., Svenson, J., Berglin, M. & Svendsen, J.S.M. (2021). Anti-colonisation effect of Au surfaces with self-assembled molecular monolayers functionalised with antimicrobial peptides on <i>S. Epidermidis. Antibiotics, 10</i>(12), 1516. Also available in Munin at <a href=https://hdl.handle.net/10037/23420>https://hdl.handle.net/10037/23420</a>.en_US
dc.relation.isbasedonJuskewitz, E. (2022). Replication Data for: "Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric naphthopyrone isolated from a marine fungus." DataverseNO, V1, <a href=https://doi.org/10.18710/6Z0VJX> https://doi.org/10.18710/6Z0VJX</a>.en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)
dc.subject.courseIDDOKTOR-003
dc.subjectMicrobiologyen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectAntibioticen_US
dc.subjectMarine environmenten_US
dc.subjectFtsZen_US
dc.subjectAMPen_US
dc.subjectPeptidomimeticen_US
dc.subjectEusyntyelamidesen_US
dc.subjectDigiBioticsen_US
dc.subjectESKAPEen_US
dc.titleAntimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimeticsen_US
dc.typeDoctoral thesisen_US
dc.typeDoktorgradsavhandlingen_US


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