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dc.contributor.authorHalvorsen, Dag S.
dc.date.accessioned2022-08-03T10:42:38Z
dc.date.available2022-08-03T10:42:38Z
dc.date.issued2007
dc.description.abstractMyocardial infarction and stroke are leading causes of death and disability iii the Western world, and substantial resources are spent on treatment, care and rehabilitation. A marked reduction in cardiovascular mortality has been observed in both genders in Norway during the 1980s and 1990s (Statistics Norway), probably due to both improved prevention and treatment of the acute ischemic event. In spite of this, cardiovascular diseases (CVD) accounted for nearly 40 % of the total mortality in 2004 (Statistics Norway). Atherosclerosis is an age-related disorder, and as the population ages, the burden of CVD will increase. A better understanding of the pathogenesis and mechanisms behind atherosclerosis is needed to improve preventive and therapeutic strategies. Endothelial dysfunction with progressive lipid accumulation in the vessel wall and formation of an atheromatous plaque is the hallmark of atherosclerosis, and an important cause of cardiovascular events. Atherosclerosis is considered a dynamic inflammatory process rather than a passive process of lipid accumulation [1]. Recent research indicates that plaque pathology is more essential than the stenotic flow-reduction for the risk of acute ischemic events [2-4]. Some authors claim that a significant number of patients with coronary heart disease (CHD) lack conventional risk factors (cigarette smoking, diabetes, hyperlipidemia, and hypertension) [5,6]. This claim implies that other risk factors may play a pivotal role in atherosclerosis, and the search for non-traditional risk factors, such as infectious and/or inflammatory causes, has been extensive during the last decade.en_US
dc.identifier.alma990715490054702201
dc.identifier.issn0801-017x
dc.identifier.urihttps://hdl.handle.net/10037/25928
dc.language.isoengen_US
dc.publisherUniversitetet i Tromsøen_US
dc.publisherUniversity of Tromsøen_US
dc.relation.ispartofseriesISM skriftserie Nr. 93, 2007en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2007 The Author(s)en_US
dc.subjectImmunoglobulin Gen_US
dc.subjectAtherosclerosisen_US
dc.subjectCross Infectionen_US
dc.subjectChlamydophila pneumoniaeen_US
dc.subjectDissertations, Academic as Topicen_US
dc.subjectImmunoglobulin Aen_US
dc.titleInfection, inflammation and artherosclerosisen_US
dc.typeDoctoral thesisen_US
dc.typeDoktorgradsavhandlingen_US


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