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Synthesis of aromatic lactone analogues of Lipoxin A4

Permanent link
https://hdl.handle.net/10037/26125
DOI
https://doi.org/10.1186/s13104-022-05917-4
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Date
2022-02-09
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Ismael, Aya; Zeeshan, Muhammad; Hansen, Jørn H
Abstract
Objective: Synthesis of novel aromatic Lipoxin A4 lactone analogues.

Results: Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields, employing 2-deoxy-d-ribose as a chiral pool starting material and the classical E-selective Wittig olefnation.

Publisher
BMC
Citation
Ismael, Zeeshan, Hansen. Synthesis of aromatic lactone analogues of Lipoxin A4. BMC Research Notes. 2022;15(1)
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