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Complementary and alternative medicine modalities used to treat adverse effects of anti‑cancer treatment among children and young adults: a systematic review and meta‑analysis of randomized controlled trials

Permanent lenke
https://hdl.handle.net/10037/26425
DOI
https://doi.org/10.1186/s12906-022-03537-w
Thumbnail
Åpne
article.pdf (2.177Mb)
Publisert versjon (PDF)
Dato
2022-04-02
Type
Journal article
Tidsskriftartikkel
Peer reviewed
Article has an altmetric score of 7
Forfatter
Mora, Dana Catalina; Overvåg, Grete; Jong, Miek; Kristoffersen, Agnete Egilsdatter; Stavleu, Debbie C.; Liu, J Ping; Stub, Trine
Sammendrag
Background - Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was to perform a systematic review and meta-analysis about the use and effect of CAM modalities to treat adverse effects of conventional cancer treatment among children and young adults.

Methods - Six scientific research databases were used to identify randomized controlled trials (RCTs) from 1990 to September 2020. Included studies investigated the use of CAM to treat cancer treatment related adverse effects in children and young adults compared to controls.

Results - Twenty RCTs comprising 1,069 participants were included in this review. The included studies investigated acupuncture, mind–body therapies, supplements, and vitamins for chemotherapy-induced nausea and vomiting (CINV), oral mucositis, and anxiety among children and young adults who underwent conventional cancer treatment. Seven studies (315 participants) were included in the meta-analysis. The overall effect of CAM (including acupuncture and hypnosis only) on chemotherapy-induced nausea and/or vomiting and controls was statistically significant with a standard mean difference of -0.54, 95% CI [-0.77, -0.31] I2 = 0% (p < 0.00001). There was a significant difference between acupuncture and controls (n = 5) for intensity and/or episodes of CINV with an SMD -0.59, 95% CI [-0.85, -0.33] (p < 0.00001). No significant difference was found between hypnosis and controls (n = 2) for severity or episodes of CINV with an SMD -0.41, 95% CI [-1.09, 0.27] I2 = 41% (p = 0.19).

Conclusion - Current evidence from this meta-analysis of randomized controlled trials shows that CAM, including acupuncture and hypnosis only, is effective in reducing chemotherapy-induced nausea and vomiting in children and young adults. More rigorous trials and long-term effects should be investigated if acupuncture and hypnosis are to be recommended for clinical use.

Er en del av
Mora, D.C. (2023). Complementary and alternative medicine use for supportive care in childhood cancer - Prevalence of use, effectiveness, safety and clinical practice. (Doctoral thesis). https://hdl.handle.net/10037/30620
Forlag
BMC
Sitering
Mora DC, Overvåg G, Jong M, Kristoffersen AE, Stavleu, Liu JP, Stub T. Complementary and alternative medicine modalities used to treat adverse effects of anti‑cancer treatment among children and young adults: a systematic review and meta‑analysis of randomized controlled trials. BMC Complementary Medicine and Therapies. 2022
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