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Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial

Permanent lenke
https://hdl.handle.net/10037/26742
DOI
https://doi.org/10.1002/ehf2.13985
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article.pdf (1.328Mb)
Publisert versjon (PDF)
Dato
2022-05-26
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Langlo, Knut Asbjørn Rise; Lundgren, Kari Margrethe; Zanaboni, Paolo; Mo, Rune; Ellingsen, Øyvind; Hallan, Stein; Aksetøy, Inger-Lise Aamot; Dalen, Håvard
Sammendrag
Aims To investigate the associations of cardiorespiratory fitness with cardiac, vascular, renal and cardiorenal characteristics in chronic heart failure in a telerehabilitation randomized clinical trial. Secondly, to evaluate the associations of cardiorenal syndrome with the effects of exercise.

2peak) measurement and 6-min walk test (6MWT). Baseline VO2peak and 6MWT distance was 0.85 mL*min-1 *kg-1 lower and 20 m shorter per 10 mL/min/1.73m2 lower estimated glomerular filtration rate (both P < 0.001). Heart failure patients with cardiorenal syndrome had 3.5 (1.1) mL*min-1 *kg-1 lower VO2peak and diastolic dysfunction grade 2–3, and elevated filling pressure was >50% more common compared with those without (all P < 0.05). At the 3-month post-intervention follow-up, only the non-CRS patients in the intervention group increased VO2peak (0.73 (0.51) mL*min-1 *kg-1 ), whereas VO2peak in the CRS subpopulation of controls decreased (-1.34 (0.43) mL*min-1 *kg-1 ). Cardiorenal syndrome was associated with a decrease in VO2peak in CRS patients compared with non-CRS patients, -0.91 (0.31) vs. 0.39 (0.35) mL*min-1 *kg-1 respectively, P = 0.013.

Conclusions Cardiorenal syndrome was negatively associated with VO2peak and 6MWT distance in chronic HF, and the associations were stronger than for heart failure phenotypes and other characteristics. The effect of exercise was negatively associated with cardiorenal syndrome. Exercise seems to be as important in heart failure patients with cardiorenal syndrome, and future studies should include CRS patients to reveal the most beneficial type of exercise.

Forlag
Wiley
Sitering
Langlo, Lundgren, Zanaboni, Mo, Ellingsen, Hallan, Aksetøy, Dalen. Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial. ESC Heart Failure. 2022
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