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dc.contributor.authorNorheim, Arne Johan
dc.contributor.authorFønnebø, Vinjar
dc.contributor.authorLindeland, John Petter
dc.contributor.authorVarpe, Terje
dc.contributor.authorBigset, Catarina
dc.contributor.authorStub, Trine
dc.contributor.authorKristoffersen, Agnete Egilsdatter
dc.date.accessioned2022-09-29T08:39:25Z
dc.date.available2022-09-29T08:39:25Z
dc.date.issued2022-08-06
dc.description.abstractBackground - Reflexology is commonly used as an adjunct to conventional treatment by patients with respiratory tract infections. The effect of reflexology needs to be tested in a full-scale randomized controlled study. Small early-phase trials can give an indication on whether full-size clinical trials are warranted. The objective of this study is to determine whether the study design is feasible in a full-scale study of reflexology as an add-on to usual care compared to usual care alone in acute rhinosinusitis, and further if there is a statistical indication of an effect of reflexology warranting a full-scale study.<p> <p>Methods - 20 patients with symptoms compatible with acute rhinosinusitis, and an illness duration of 28 days or less were randomized to additional reflexology treatment along with usual medical care, or usual care alone. The patients scored how much each of 16 sinus-related symptoms bothered them in the past few days on a six-point scale (zero = no problem to five = severe problem). To determine if there is a statistical indication of an effect of reflexology warranting a full-scale study, the separation test was used.<p> <p>Results - The methodology was considered feasible and could therefore be applied in a full-scale study of reflexology for acute rhinosinusitis. The mean reduction in symptom score from baseline to day two was 0.95 in the reflexology group and 0.78 in the control group. From baseline to day ten the mean reduction in symptom score was 2.12 in the reflexology group and 1.63 in the control group. A statistical indication of effect in a full-scale study in favor of reflexology was found from baseline to day ten but not from baseline to day two.<p> <p>Conclusions - The research methodology in this study could be used in a full-scale study of reflexology in acute sinusitis. The results from the separation test indicates an effect warranting a full-scale study of reflexology regarding effects in acute sinusitis ten days after treatment.en_US
dc.identifier.citationNorheim AJ, Fønnebø vm, Lindeland JP, Varpe T, Bigset, Stub T, Kristoffersen AE. Reflexology for acute rhinosinusitis – Results from a blinded, early-phase comparative trial. Explore: The Journal of Science and Healing. 2022en_US
dc.identifier.cristinIDFRIDAID 2055945
dc.identifier.doi10.1016/j.explore.2022.08.002
dc.identifier.issn1550-8307
dc.identifier.issn1878-7541
dc.identifier.urihttps://hdl.handle.net/10037/26935
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalExplore: The Journal of Science and Healing
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleReflexology for acute rhinosinusitis – Results from a blinded, early-phase comparative trialen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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