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dc.contributor.authorBrobak, Karl Marius
dc.contributor.authorAndreassen, Runa Marie
dc.contributor.authorMelsom, Toralf
dc.contributor.authorHøieggen, Aud
dc.contributor.authorNorvik, Jon Viljar
dc.contributor.authorSolbu, Marit Dahl
dc.date.accessioned2022-10-06T10:41:51Z
dc.date.available2022-10-06T10:41:51Z
dc.date.issued2022-10-03
dc.description.abstractPurpose: Subclinical chronic kidney disease is known to exacerbate hypertension and progression of kidney damage. In order to initiate timely interventions, early biomarkers for this vicious circle are needed. Our aim was to describe the cross-sectional associations of urinary orosomucoid and urinary N-acetyl-b-D-glucosaminidase (NAG) with blood pressure and the longitudinal associations of urinary orosomucoid and NAG to hypertension after 7 years, and to compare the strength of these associations to the urinary albumin excretion (UAE).<p> <p>Material and methods: The Tromsø Study is a population-based, prospective study of inhabitants of the municipality of Tromsø, Northern Norway. Morning spot urine samples were collected on three consecutive days in the Tromsø 6 survey (2007–2008). We assessed the crosssectional associations of urinary orosomucoid, NAG and UAE with blood pressure in Tromsø 6. In a cohort of participants attending Tromsø 6 and Tromsø 7 (2015–2016), we studied whether urinary biomarkers were longitudinally associated with hypertension. <p>Results: A total of 7197 participants with a mean age of 63.5 years (SD 9.2), and a mean blood pressure of 141/78 mmHg (SD 23.0/10.6), were included in the study. Orosomucoid and UAE, but not NAG, was significantly associated with systolic and diastolic blood pressure in all the crude and multivariable cross-sectional analyses. Orosomucoid had consistently, although marginally, stronger associations with blood pressure. Incident hypertension at follow-up (Tromsø 7) was consistently significantly associated with urinary orosomucoid, but not urinary NAG or UAE. However, the standardized regression coefficients for orosomucoid were only marginally stronger than the standardized regression coefficients for ACR. <p>Conclusion: In a cohort from the general population urine orosomucoid had a stronger crosssectional association with blood pressure than UAE. After 7 years, urine orosomucoid showed the strongest association with incident hypertension. There were varying and weak associations between U-NAG, blood pressure and hypertension.en_US
dc.identifier.citationBrobak KM, Andreassen, Melsom, Høieggen, Norvik, Solbu. Associations of urinary orosomucoid, N-acetyl-β-D-glucosaminidase, and albumin with blood pressure and hypertension during 7 years of follow-up. The Tromsø Stud. Blood Pressure. 2022en_US
dc.identifier.cristinIDFRIDAID 2054340
dc.identifier.doi10.1080/08037051.2022.2128043
dc.identifier.issn0803-7051
dc.identifier.issn1651-1999
dc.identifier.urihttps://hdl.handle.net/10037/26986
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofBrobak, K.M. (2024). Novel biomarkers in hypertension. (Doctoral thesis). <a href=https://hdl.handle.net/10037/33114>https://hdl.handle.net/10037/33114</a>.
dc.relation.journalBlood Pressure
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAssociations of urinary orosomucoid, N-acetyl-β-D-glucosaminidase, and albumin with blood pressure and hypertension during 7 years of follow-up. The Tromsø Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)