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dc.contributor.authorAzulay, Naomi
dc.contributor.authorBjørkholt Olsen, Roy
dc.contributor.authorNielsen, Christopher Sivert
dc.contributor.authorStubhaug, Audun
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorFrigessi, Arnoldo
dc.contributor.authorRosseland, Leiv Arne
dc.contributor.authorTronstad, Christian
dc.date.accessioned2022-10-26T12:10:11Z
dc.date.available2022-10-26T12:10:11Z
dc.date.issued2022-07-14
dc.description.abstractBoth diabetes mellitus (DM) and the metabolic syndrome (MetS) are associated with autonomic neuropathy, which predisposes to cardiac events and death. Measures of heart rate variability (HRV) can be used to monitor the activity of the autonomic nervous system (ANS), and there are strong indications that HRV can be used to study the progression of ANS-related diabetes complications. This study aims to investigate diferences in HRV in healthy, MetS and diabetic populations. Based on 7880 participants from the sixth health survey in Tromsø (Tromsø 6, 2007–2008), we found a signifcant negative association between the number of MetS components and HRV as estimated from short-term pulse wave signals (PRV). This decrease in PRV did not appear to be linear, instead it leveled of after the third component, with no signifcant diference in PRV between the MetS and DM populations. There was a signifcant negative association between HbA1c and PRV, showing a decrease in PRV occurring already within the normal HbA1c range. The MetS and DM populations are diferent from healthy controls with respect to PRV, indicating impaired ANS in both conditions. In the future, a study with assessment of PRV measurements in relation to prospective cardiovascular events seems justifed.en_US
dc.identifier.citationAzulay, Bjørkholt Olsen, Nielsen, Stubhaug, Jenssen, Schirmer, Frigessi, Rosseland, Tronstad. Reduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007–2008. Scientific Reports. 2022;12(1)en_US
dc.identifier.cristinIDFRIDAID 2058877
dc.identifier.doi10.1038/s41598-022-15824-0
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/27138
dc.language.isoengen_US
dc.publisherNatureen_US
dc.relation.journalScientific Reports
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/SOCIETAL CHALLENGES/848099/EU/Molecular Mechanisms Associating Chronic Pain with Fatigue, Affective Disorders, Cardiovascular Disease and Total Comorbidity/PainFACT/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleReduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007–2008en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)