dc.contributor.author | Kurnikowski, Amelie | |
dc.contributor.author | Nordheim, Espen | |
dc.contributor.author | Schwaiger, Elisabeth | |
dc.contributor.author | Krenn, Simon | |
dc.contributor.author | Harreiter, Jürgen | |
dc.contributor.author | Kautzky-Willer, Alexandra | |
dc.contributor.author | Leutner, Michael | |
dc.contributor.author | Werzowa, Johannes | |
dc.contributor.author | Tura, Andrea | |
dc.contributor.author | Budde, Klemens | |
dc.contributor.author | Eller, Kathrin | |
dc.contributor.author | Pascual, Julio | |
dc.contributor.author | Krebs, Michael | |
dc.contributor.author | Jenssen, Trond Geir | |
dc.contributor.author | Hecking, Manfred | |
dc.date.accessioned | 2022-11-22T08:47:22Z | |
dc.date.available | 2022-11-22T08:47:22Z | |
dc.date.issued | 2022-09-01 | |
dc.description.abstract | Posttransplant diabetes mellitus (PTDM) and prediabetes (impaired glucose tolerance [IGT] and impaired fasting glucose [IFG]) are associated with cardiovascular events. We assessed the diagnostic performance of fasting plasma glucose (FPG) and HbA<sub>1c</sub> as alternatives to oral glucose tolerance test (OGTT)-derived 2-hour plasma glucose (2hPG) using sensitivity and specificity in 263 kidney transplant recipients (KTRs) from a clinical trial. Between visits at 6, 12, and 24 months after transplantation, 28%–31% of patients switched glycemic category (normal glucose tolerance [NGT], IGT/IFG, PTDM). Correlations of FPG and HbA1c against 2hPG were lower at 6 months (r = 0.59 [FPG against 2hPG]; r = 0.45 [HbA1c against 2hPG]) vs. 24 months (r = 0.73 [FPG against 2hPG]; r = 0.74 [HbA<sub>1c</sub> against 2hPG]). Up to 69% of 2hPG-defined PTDM cases were missed by conventional HbA<sub>1c</sub> and FPG thresholds. For prediabetes, concordance of FPG and HbA<sub>1c</sub> with 2hPG ranged from 6%–9%. In conclusion, in our well-defined randomized trial cohort, one-third of KTRs switched glycemic category over 2 years and although the correlations of FPG and HbA<sub>1c</sub> with 2hPG improved with time, their diagnostic concordance was poor for PTDM and, especially, prediabetes. Considering posttransplant metabolic instability, FPG's and HbA<sub>1c</sub>'s diagnostic performance, the OGTT remains indispensable to diagnose PTDM and prediabetes after kidney transplantation. | en_US |
dc.identifier.citation | Kurnikowski, Nordheim, Schwaiger, Krenn, Harreiter, Kautzky-Willer, Leutner, Werzowa, Tura, Budde, Eller, Pascual, Krebs, Jenssen, Hecking. Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: A 2-year diagnostic accuracy study of participants from a randomized controlled trial. American Journal of Transplantation. 2022 | en_US |
dc.identifier.cristinID | FRIDAID 2073599 | |
dc.identifier.doi | 10.1111/ajt.17187 | |
dc.identifier.issn | 1600-6135 | |
dc.identifier.issn | 1600-6143 | |
dc.identifier.uri | https://hdl.handle.net/10037/27453 | |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | American Journal of Transplantation | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: A 2-year diagnostic accuracy study of participants from a randomized controlled trial | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |