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dc.contributor.authorSchanche, Torstein Lindahl
dc.contributor.authorFilseth, Ole Magnus
dc.contributor.authorØsterud, Bjarne
dc.contributor.authorKondratyev, Timofey
dc.contributor.authorSieck, Gary C.
dc.contributor.authorTveita, Torkjel
dc.date.accessioned2022-11-22T12:55:38Z
dc.date.available2022-11-22T12:55:38Z
dc.date.issued2022-04-29
dc.description.abstractIntroduction: Due to functional alterations of blood platelets and coagulation enzymes at low temperatures, excessive bleeding is a well-recognized complication in victims of accidental hypothermia and may present a great clinical challenge. Still, it remains largely unknown if hemostatic function normalizes upon rewarming. The aim of this study was to investigate effects of hypothermia and rewarming on blood coagulation in an intact porcine model.<p> <p>Methods: The animals were randomized to cooling and rewarming (n = 10), or to serve as normothermic, time-matched controls (n = 3). Animals in the hypothermic group were immersion cooled in ice water to 25°C, maintained at 25°C for 1 h, and rewarmed to 38°C (normal temperature in pigs) using warm water. Clotting time was assessed indirectly at different temperatures during cooling and rewarming using a whole blood coagulometer, which measures clotting time at 38°C.<p> <p>Results: Cooling to 25°C led to a significant increase in hemoglobin, hematocrit and red blood cell count, which persisted throughout rewarming. Cooling also caused a transiently decreased white blood cell count that returned to baseline levels upon rewarming. After rewarming from hypothermia, clotting time was significantly shortened compared to pre-hypothermic baseline values. In addition, platelet count was significantly increased.<p> <p>Discussion/Conclusion: We found that clotting time was significantly reduced after rewarming from hypothermia. This may indicate that rewarming from severe hypothermia induces a hypercoagulable state, in which thrombus formation is more likely to occur.en_US
dc.identifier.citationSchanche, Filseth, Østerud, Kondratyev, Sieck, Tveita. Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model. Frontiers in Physiology. 2022;13en_US
dc.identifier.cristinIDFRIDAID 2060797
dc.identifier.doi10.3389/fphys.2022.901908
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/10037/27471
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Physiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleEnhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Modelen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)