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dc.contributor.authorTzanova, Martina Martin
dc.contributor.authorMoretti, Federica
dc.contributor.authorGrassi, Gabriele
dc.contributor.authorStein, Paul
dc.contributor.authorHiorth, Marianne
dc.contributor.authorAbrami, Michela
dc.contributor.authorGrassi, Mario
dc.contributor.authorDi Cagno, Massimiliano Pio
dc.date.accessioned2022-12-01T14:17:06Z
dc.date.available2022-12-01T14:17:06Z
dc.date.issued2022-08-25
dc.description.abstractThe correlation between in vivo and in vitro data is yet not sufficiently optimized to allow a significant reduction and replacement of animal testing in pharmaceutical development. One of the main reasons for this lies in the poor mechanistic understanding and interpretation of the physical mechanisms enabling formulation rely on for deploying the drug. One mechanism that still lacks a proper interpretation is the kinetics of drug release from nanocarriers. In this work, we investigate two different types of classical enabling formulations – i) cyclodextrin solutions and ii) liposomal dispersions – by a combination of an experimental method (i.e. UV–Vis localized spectroscopy) and mathematical modelling/numerical data fitting. With this approach, we are able to discriminate precisely between the amount of drug bound to nanocarriers or freely dissolved at any time point; in addition, we can precisely estimate the binding and diffusivity constants of all chemical species (free drug/bound drug). The results obtained should serve as the first milestone for the further development of reliable in vitro/in silico models for the prediction of in vivo drug bioavailability when enabling formulations are used.en_US
dc.identifier.citationTzanova, Moretti, Grassi, Stein, Hiorth, Abrami, Grassi, Di Cagno. Modelling drug diffusion through unstirred water layers allows real-time quantification of free/loaded drug fractions and release kinetics from colloidal-based formulations. European journal of pharmaceutics and biopharmaceutics. 2022;178:168-178en_US
dc.identifier.cristinIDFRIDAID 2046827
dc.identifier.doi10.1016/j.ejpb.2022.08.009
dc.identifier.issn0939-6411
dc.identifier.issn1873-3441
dc.identifier.urihttps://hdl.handle.net/10037/27650
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEuropean journal of pharmaceutics and biopharmaceutics
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleModelling drug diffusion through unstirred water layers allows real-time quantification of free/loaded drug fractions and release kinetics from colloidal-based formulationsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)