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dc.contributor.authorWells, Jonathan C. K.
dc.contributor.authorCole, Tim J.
dc.contributor.authorCortina-Borja, Mario
dc.contributor.authorSear, Rebecca
dc.contributor.authorLeon, David A.
dc.contributor.authorMarphatia, Akanksha A.
dc.contributor.authorMurray, Joseph
dc.contributor.authorWehrmeister, Fernando C.
dc.contributor.authorOliveira, Paula D.
dc.contributor.authorGonçalves, Helen
dc.contributor.authorOliveira, Isabel O.
dc.contributor.authorMenezes, Ana Maria B.
dc.date.accessioned2022-12-28T14:21:07Z
dc.date.available2022-12-28T14:21:07Z
dc.date.issued2022-09-20
dc.description.abstractBackground: Environmental exposures in early life explain variability in many physiological and behavioural traits in adulthood. Recently, we showed that exposure to a composite marker of low maternal capital explained the clustering of adverse behavioural and physical traits in adult daughters in a Brazilian birth cohort. These associations were strongly mediated by whether or not the daughter had reproduced by the age of 18 years. Using evolutionary life history theory, we attributed these associations to trade-offs between competing outcomes, whereby daughters exposed to low maternal capital prioritised investment in reproduction and defence over maintenance and growth. However, little is known about such trade-offs in sons.<p> <p>Methods: We investigated 2,024 mother–son dyads from the same birth cohort. We combined data on maternal height, body mass index, income, and education into a composite “maternal capital” index. Son outcomes included reproductive status at the age of 18 years, growth trajectory, adult anthropometry, body composition, cardio-metabolic risk, educational attainment, work status, and risky behaviour (smoking, violent crime). We tested whether sons' early reproduction and exposure to low maternal capital were associated with adverse outcomes and whether this accounted for the clustering of adverse outcomes within individuals.<p> <p>Results: Sons reproducing early were shorter, less educated, and more likely to be earning a salary and showing risky behaviour compared to those not reproducing, but did not differ in foetal growth. Low maternal capital was associated with a greater likelihood of sons' reproducing early, leaving school, and smoking. High maternal capital was positively associated with sons' birth weight, adult size, and staying in school. However, the greater adiposity of high-capital sons was associated with an unhealthier cardio-metabolic profile.<p> <p>Conclusion: Exposure to low maternal investment is associated with trade-offs between life history functions, helping to explain the clustering of adverse outcomes in sons. The patterns indicated future discounting, with reduced maternal investment associated with early reproduction but less investment in growth, education, or healthy behaviour. However, we also found differences compared to our analyses of daughters, with fewer physical costs associated with early reproduction. Exposure to intergenerational “cycles of disadvantage” has different effects on sons vs. daughters, hence interventions may have sex-specific consequences.en_US
dc.identifier.citationWells, Cole, Cortina-Borja, Sear, Leon, Marphatia, Murray, Wehrmeister, Oliveira, Gonçalves, Oliveira, Menezes. Life history trade-offs associated with exposure to low maternal capital are different in sons compared to daughters: Evidence from a prospective Brazilian birth cohort. Frontiers in Public Health. 2022;10
dc.identifier.cristinIDFRIDAID 2077152
dc.identifier.doi10.3389/fpubh.2022.914965
dc.identifier.issn2296-2565
dc.identifier.urihttps://hdl.handle.net/10037/27936
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Public Health
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleLife history trade-offs associated with exposure to low maternal capital are different in sons compared to daughters: Evidence from a prospective Brazilian birth cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)