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dc.contributor.authorJørgensen, Helle
dc.contributor.authorHorvath-Puho, Erzsebet
dc.contributor.authorLaugesen, Kristina
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John Bjarne
dc.contributor.authorToft Sørensen, Henrik
dc.date.accessioned2023-03-09T12:00:21Z
dc.date.available2023-03-09T12:00:21Z
dc.date.issued2022-12-22
dc.description.abstractBackground - The psychologic consequences of acute venous thromboembolism (VTE) have not been investigated in depth.<p> <p>Objectives We aimed to examine the association between VTE and the risk of subsequent depression.<p> <p>Methods - Using Danish nationwide registries, we established a population-based cohort of 64 596 individuals with incident VTE during 1996 to 2016 and a comparison cohort (n = 322 999) selected randomly from the general population and individually matched by birth year, sex, and calendar year of VTE. The participants were followed up for 3 years, and depression was defined as any hospital diagnosis of depression or ≥1 prescription for antidepressants. Incidence rates were computed as the number of events per 1000 person-years, and hazard ratios with 95% CIs were computed as estimates of the risk conferred by VTE using the comparison cohort as reference. We estimated absolute risks using cumulative incidence functions, treating death as a competing event.<p> <p>Results - Depression was observed in 6225 individuals after VTE and 16 363 members of the comparison cohort (incidence rates of 44.4 and 19.4 per 1000 person-years, respectively). The absolute risk of depression was 10.3% (95% CI, 10.1%-10.6%) in the VTE cohort and 5.6% (95% CI, 5.5%-5.6%) in the comparison cohort, corresponding to 4.7 excess cases of depression per 100 individuals with VTE. VTE was associated with a 2.35-fold (95% CI, 2.28-2.43) increased risk of depression compared with that in the comparison cohort. The association was attenuated after adjustments for socioeconomic status and comorbidities (hazard ratio, 1.91; 95% CI, 1.85-1.97).<p> <p>Conclusion - VTE was associated with an increased risk of depression after adjustment for comorbidities.en_US
dc.identifier.citationJørgensen, Horvath-Puho, Laugesen, Brækkan, Hansen, Toft Sørensen. Venous thromboembolism and risk of depression: a population-based cohort study. Journal of Thrombosis and Haemostasis. 2022en_US
dc.identifier.cristinIDFRIDAID 2112968
dc.identifier.doi10.1016/j.jtha.2022.12.006
dc.identifier.issn1538-7933
dc.identifier.issn1538-7836
dc.identifier.urihttps://hdl.handle.net/10037/28706
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Thrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleVenous thromboembolism and risk of depression: a population-based cohort studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)