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dc.contributor.authorAl-Mahdi, Rania Ali Muhsen
dc.contributor.authorStangvaltaite-Mouhat, Lina
dc.contributor.authorAleksejuniene, Jolanta
dc.contributor.authorStankeviciene, Indre
dc.contributor.authorTømmerås, Berit
dc.contributor.authorPuriene, Alina
dc.contributor.authorAl-Haroni, Mohammed
dc.date.accessioned2023-03-16T12:50:39Z
dc.date.available2023-03-16T12:50:39Z
dc.date.issued2022
dc.description.abstractThe current study examined the association between the carbonic anhydrase VI (CA VI) copy number variations (CNVs) and dental caries experience in adults. In total, 202 of 35-72 years old subjects participating in the Lithuanian National Oral Health Survey (LNOHS) agreed to provide saliva samples, thus their data were included in the current study. Information about sociodemographic, environmental, and behavioural determinants was acquired via the self-administered World Health Organisation (WHO) questionnaire. Fluoride levels in the drinking water were recorded based on information provided by water suppliers. Dental caries experience was recorded by one calibrated examiner using the WHO criteria for recording caries on smooth (including proximal, buccal, and oral) or occlusal surfaces. Caries experience was measured as the total number of decayed (D3), missing (M), filled (F) surfaces (D3MFS). DNA was extracted from saliva samples to examine CA VI CNVs using the QX200 droplet digital PCR system. Negative binomial regression and Poisson regression analyses were employed for data analyses. Based on multivariable regression analyses, higher copy number of CA VI were associated with higher caries experience on smooth surfaces (IRR 1.04, 95% CI 1.005 - 1.08) and occlusal surfaces (IRR 1.02, 95% CI 1.003 - 1.04). Positive associations between higher copy number of CA VI and higher caries experience on smooth and occlusal surfaces were found, suggesting that the CA VI coding gene may be associated with caries development. Future studies are needed to validate our results and to examine the underlying mechanisms of such associations.en_US
dc.identifier.citationAl-Mahdi R, Stangvaltaite-Mouhat L, Aleksejuniene, Stankeviciene, Tømmerås, Puriene, Al-Haroni. Association between Carbonic Anhydrase VI (CA VI) gene copy number and dental caries experience. Caries Research. 2022en_US
dc.identifier.cristinIDFRIDAID 2096582
dc.identifier.doi10.1159/000528749
dc.identifier.issn0008-6568
dc.identifier.issn1421-976X
dc.identifier.urihttps://hdl.handle.net/10037/28774
dc.language.isoengen_US
dc.publisherKarger Publishersen_US
dc.relation.journalCaries Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAssociation between Carbonic Anhydrase VI (CA VI) gene copy number and dental caries experienceen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)