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dc.contributor.authorReponen, Elina Johanna
dc.contributor.authorUeland, Thor
dc.contributor.authorRokicki, Jaroslav
dc.contributor.authorBettella, Francesco
dc.contributor.authorAas, Monica
dc.contributor.authorWerner, Maren C. F.
dc.contributor.authorDieset, Ingrid
dc.contributor.authorSteen, Nils E.
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorTesli, Martin Steen
dc.date.accessioned2023-06-14T06:49:13Z
dc.date.available2023-06-14T06:49:13Z
dc.date.issued2023-05-05
dc.description.abstractIndividuals with schizophrenia and bipolar disorder are at an increased risk of cardiovascular disease (CVD), and a range of biomarkers related to CVD risk have been found to be abnormal in these patients. Common genetic factors are a putative underlying mechanism, alongside lifestyle factors and antipsychotic medication. However, the extent to which the altered CVD biomarkers are related to genetic factors involved in schizophrenia and bipolar disorder is unknown. In a sample including 699 patients with schizophrenia, 391 with bipolar disorder, and 822 healthy controls, we evaluated 8 CVD risk biomarkers, including BMI, and fasting plasma levels of CVD biomarkers from a subsample. Polygenic risk scores (PGRS) were obtained from genome-wide associations studies (GWAS) of schizophrenia and bipolar disorder from the Psychiatric Genomics Consortium. The CVD biomarkers were used as outcome variables in linear regression models including schizophrenia and bipolar disorder PGRS as predictors, age, sex, diagnostic category, batch and 10 principal components as covariates, controlling for multiple testing by Bonferroni correction for the number of independent tests. Bipolar disorder PGRS was significantly (p = 0.03) negatively associated with BMI after multiple testing correction, and schizophrenia PGRS was nominally negatively associated with BMI. There were no other significant associations between bipolar or schizophrenia PGRS, and other investigated CVD biomarkers. Despite a range of abnormal CVD risk biomarkers in psychotic disorders, we only found a significant negative association between bipolar disorder PGRS and BMI. This has previously been shown for schizophrenia PGRS and BMI, and warrants further exploration.en_US
dc.identifier.citationReponen, Ueland, Rokicki, Bettella, Aas, Werner, Dieset, Steen, Andreassen, Tesli. Polygenic risk for schizophrenia and bipolar disorder in relation to cardiovascular biomarkers. European Archives of Psychiatry and Clinical Neuroscience. 2023:1-8en_US
dc.identifier.cristinIDFRIDAID 2154190
dc.identifier.doihttps://doi.org/10.1007/s00406-023-01591-0
dc.identifier.issn0940-1334
dc.identifier.issn1433-8491
dc.identifier.urihttps://hdl.handle.net/10037/29397
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalEuropean Archives of Psychiatry and Clinical Neuroscience
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/847776/EU/Predicting comorbid cardiovascular disease in individuals with mental disorder by decoding disease mechanisms/CoMorMent/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePolygenic risk for schizophrenia and bipolar disorder in relation to cardiovascular biomarkersen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)