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dc.contributor.authorLillås, Bjørn Steinar Demma
dc.contributor.authorTøndel, Camilla
dc.contributor.authorMelsom, Toralf
dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorMarti, Hans Peter
dc.contributor.authorVikse, Bjørn Egil
dc.date.accessioned2023-08-15T08:40:52Z
dc.date.available2023-08-15T08:40:52Z
dc.date.issued2023-02-20
dc.description.abstract<b><p>Introduction:</b> Renal functional response (RFR) is the acute increase in glomerular filtration rate (GFR) after a protein load. Low RFR is a marker of single nephron hyperfiltration. Low birth weight (LBW) is associated with reduced number of nephrons, lower kidney function, and smaller kidneys in adults. In the present study, we investigate the associations among LBW, kidney volume, and RFR. <b><p>Methods:</b> We studied adults aged 41 to 52 years born with either LBW (#2300 g) or normal birth weight (NBW; 3500–4000 g). GFR was measured using plasma clearance of iohexol. A stimulated GFR (sGFR) was measured on a separate day after a protein load of 100 g using a commercially available protein powder, and RFR was calculated as delta GFR. Kidney volume was estimated from magnetic resonance imaging (MRI) images using the ellipsoid formula. <b><p>Results:</b> A total of 57 women and 48 men participated. The baseline mean SD GFR was 118 17 ml/min for men and 98 19 ml/min for women. The overall mean RFR was 8.2 7.4 ml/min, with mean RFR of 8.3 8.0 ml/min and 8.1 6.9 ml/min in men and women, respectively (P ¼ 0.5). No birth-related variables were associated with RFR. Larger kidney volume was associated with higher RFR, 1.9 ml/min per SD higher kidney volume (P ¼ 0.009). Higher GFR per kidney volume was associated with a lower RFR, 3.3ml/min per SD (P < 0.001). <b><p>Conclusion:</b> Larger kidney size and lower GFR per kidney volume were associated with higher RFR. Birth weight was not shown to associate with RFR in mainly healthy middle-aged men and womenen_US
dc.identifier.citationLillås BS, Tøndel C, Melsom T, Eriksen BO, Marti HP, Vikse BE. Renal Functional Response-Association With Birth Weight and Kidney Volume. Kidney International Reports. 2023;8(5):1034-1042en_US
dc.identifier.cristinIDFRIDAID 2127707
dc.identifier.doi10.1016/j.ekir.2023.02.1079
dc.identifier.issn2468-0249
dc.identifier.urihttps://hdl.handle.net/10037/29939
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalKidney International Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleRenal Functional Response-Association With Birth Weight and Kidney Volumeen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)