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dc.contributor.authorRasmussen, Ingrid Daae
dc.contributor.authorMittner, Matthias Bodo
dc.contributor.authorBoayue, Nya Mehnwolo
dc.contributor.authorCsifcsák, Gábor
dc.contributor.authorAslaksen, Per M
dc.date.accessioned2023-08-17T06:44:08Z
dc.date.available2023-08-17T06:44:08Z
dc.date.issued2023-04-26
dc.description.abstractBackground: Several studies on patients with Alzheimer’s disease (AD) have used transcranial direct current stimulation (tDCS) to enhance neural excitability in the left dorsolateral prefrontal cortex (lDLPFC). Interindividual differences in brain anatomy in AD patients pose a challenge to efficiently target the lDLPFC using scalpbased coordinates, calling for new and more precise tDCS protocols. Objective: The purpose of this study was to explore how AD-related neuropathology affects the tDCS-induced electric field (EF) across different DLPFC montages using computational modeling. Method: Forty-eight realistic head models were created from structural magnetic resonance scans of AD patients and healthy controls collected from a publicly available database. We compared the tDCS-induced EF in different montages applied in the literature, in addition to a high definition (HD)-tDCS montage centered at electrode F3. Results: There was an overall global reduction in EF strength in the patient group, probably due to structural alterations that were also identified in the patient group. A widespread distribution of the EF was found across the frontal lobe for bipolar montages, while HD-tDCS yielded more focal stimulation, mainly restricted to the lDLPFC. Minor differences in the EF distribution were found when comparing the HD-tDCS montages. Conclusion: Neurodegenerative alterations present in patients with AD affect the magnitude, distribution and variability of the EF. HD-tDCS montages provide more focal stimulation of the target area, compared to bipolar montages with to pronounced group differences between AD patients and healthy matched controls. This finding poses substantial limitations to the comparison of cognitive effects of tDCS both between patients and controls and within patients at different stages of disease progression.en_US
dc.identifier.citationRasmussen, Mittner, Boayue, Csifcsák, Aslaksen. Tracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCS. Neuroimage: Reports. 2023;3(2):1-8en_US
dc.identifier.cristinIDFRIDAID 2146723
dc.identifier.doi10.1016/j.ynirp.2023.100172
dc.identifier.issn2666-9560
dc.identifier.urihttps://hdl.handle.net/10037/30001
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofDaae Rasmussen, I. (2023). Transcranial Direct Current Stimulation for patients with Alzheimer’s Disease - Exploring the influence of different stimulation parameters on treatment success. (Doctoral thesis). <a href=https://hdl.handle.net/10037/31503>https://hdl.handle.net/10037/31503</a>.
dc.relation.journalNeuroimage: Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleTracking the current in the Alzheimer's brain - Systematic differences between patients and healthy controls in the electric field induced by tDCSen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)