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dc.contributor.authorDobon, Begoña
dc.contributor.authorMusciotto, Federico
dc.contributor.authorMira, Alex
dc.contributor.authorGreenacre, Michael
dc.contributor.authorSchlaepfer, Rodolph
dc.contributor.authorAguileta, Gabriela
dc.contributor.authorAstete, Leonora H.
dc.contributor.authorNgales, Marilyn
dc.contributor.authorLatora, Vito
dc.contributor.authorBattiston, Federico
dc.contributor.authorVinicius, Lucio
dc.contributor.authorMigliano, Andrea B.
dc.contributor.authorBertranpetit, Jaume
dc.date.accessioned2023-08-22T07:47:01Z
dc.date.available2023-08-22T07:47:01Z
dc.date.issued2023-05-22
dc.description.abstractEcological and genetic factors have influenced the composition of the human microbiome during our evolutionary history. We analysed the oral microbiota of the Agta, a hunter–gatherer population where some members have adopted an agricultural diet. We show that age is the strongest factor modulating the microbiome, probably through immunosenescence since we identified an increase in the number of species classified as pathogens with age. We also characterised biological and cultural processes generating sexual dimorphism in the oral microbiome. A small subset of oral bacteria is influenced by the host genome, linking host collagen genes to bacterial biofilm formation. Our data also suggest that shifting from a fish/meat diet to a rice-rich diet transforms their microbiome, mirroring the Neolithic transition. All of these factors have implications in the epidemiology of oral diseases. Thus, the human oral microbiome is multifactorial and shaped by various ecological and social factors that modify the oral environment.en_US
dc.identifier.citationDobon, Musciotto, Mira, Greenacre, Schlaepfer, Aguileta, Astete, Ngales, Latora, Battiston, Vinicius, Migliano, Bertranpetit. The making of the oral microbiome in Agta hunter-gatherers. Evolutionary Human Sciences. 2023;5en_US
dc.identifier.cristinIDFRIDAID 2156454
dc.identifier.doi10.1017/ehs.2023.9
dc.identifier.issn2513-843X
dc.identifier.urihttps://hdl.handle.net/10037/30153
dc.language.isoengen_US
dc.publisherCambridge University Pressen_US
dc.relation.journalEvolutionary Human Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleThe making of the oral microbiome in Agta hunter-gatherersen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)