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dc.contributor.authorPaluch, Amanda E.
dc.contributor.authorBajpai, Shivangi
dc.contributor.authorBallin, Marcel
dc.contributor.authorBassett, David R.
dc.contributor.authorBuford, Thomas W.
dc.contributor.authorCarnethon, Mercedes R.
dc.contributor.authorChernofsky, Ariel
dc.contributor.authorDooley, Erin E.
dc.contributor.authorEkelund, Ulf
dc.contributor.authorEvenson, Kelly R.
dc.contributor.authorGaluska, Deborah A.
dc.contributor.authorJefferis, Barbara J.
dc.contributor.authorKong, Lingsong
dc.contributor.authorKraus, William E.
dc.contributor.authorLarson, Martin G.
dc.contributor.authorLee, I-Min
dc.contributor.authorMatthews, Charles E.
dc.contributor.authorNewton, Robert L.
dc.contributor.authorNordström, Anna Hava
dc.contributor.authorNordström, Peter
dc.contributor.authorPalta, Priya
dc.contributor.authorPatel, Alpa V.
dc.contributor.authorPettee Gabriel, Kelley
dc.contributor.authorPieper, Carl F.
dc.contributor.authorPompeii, Lisa
dc.contributor.authorRees-Punia, Erika
dc.contributor.authorSpartano, Nicole L.
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorWhincup, Peter H.
dc.contributor.authorYang, Shengping
dc.contributor.authorFulton, Janet E.
dc.date.accessioned2023-08-25T11:01:41Z
dc.date.available2023-08-25T11:01:41Z
dc.date.issued2022-12-20
dc.description.abstractBackground: Taking fewer than the widely promoted “10 000 steps per day” has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose–response relationship between steps per day and CVD can help inform clinical and public health guidelines. Methods: Eight prospective studies (20 152 adults [ie, ≥18 years of age]) were included with device-measured steps and participants followed for CVD events. Studies quantified steps per day and CVD events were defined as fatal and nonfatal coronary heart disease, stroke, and heart failure. Cox proportional hazards regression analyses were completed using study-specific quartiles and hazard ratios (HR) and 95% CI were meta-analyzed with inverse-variance–weighted random effects models. Results: The mean age of participants was 63.2±12.4 years and 52% were women. The mean follow-up was 6.2 years (123 209 person-years), with a total of 1523 CVD events (12.4 per 1000 participant-years) reported. There was a significant difference in the association of steps per day and CVD between older (ie, ≥60 years of age) and younger adults (ie, <60 years of age). For older adults, the HR for quartile 2 was 0.80 (95% CI, 0.69 to 0.93), 0.62 for quartile 3 (95% CI, 0.52 to 0.74), and 0.51 for quartile 4 (95% CI, 0.41 to 0.63) compared with the lowest quartile. For younger adults, the HR for quartile 2 was 0.79 (95% CI, 0.46 to 1.35), 0.90 for quartile 3 (95% CI, 0.64 to 1.25), and 0.95 for quartile 4 (95% CI, 0.61 to 1.48) compared with the lowest quartile. Restricted cubic splines demonstrated a nonlinear association whereby more steps were associated with decreased risk of CVD among older adults. Conclusions: For older adults, taking more daily steps was associated with a progressively decreased risk of CVD. Monitoring and promoting steps per day is a simple metric for clinician–patient communication and population health to reduce the risk of CVD.en_US
dc.identifier.citationPaluch, Bajpai, Ballin, Bassett, Buford, Carnethon, Chernofsky, Dooley, Ekelund, Evenson, Galuska, Jefferis, Kong, Kraus, Larson, Lee, Matthews, Newton, Nordström AH, Nordström, Palta, Patel, Pettee Gabriel, Pieper, Pompeii, Rees-Punia, Spartano, Vasan, Whincup, Yang, Fulton. Prospective Association of Daily Steps with Cardiovascular Disease: A Harmonized Meta-Analysis. Circulation. 2023;147(2):122-131en_US
dc.identifier.cristinIDFRIDAID 2138152
dc.identifier.doi10.1161/CIRCULATIONAHA.122.061288
dc.identifier.issn0009-7322
dc.identifier.issn1524-4539
dc.identifier.urihttps://hdl.handle.net/10037/30429
dc.language.isoengen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.journalCirculation
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleProspective Association of Daily Steps with Cardiovascular Disease: A Harmonized Meta-Analysisen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)