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dc.contributor.authorNorheim, Arne Johan
dc.contributor.authorBorud, Einar Kristian
dc.contributor.authorMercer, James
dc.contributor.authorde Weerd, Louis
dc.contributor.authorWeiss, Thomas
dc.contributor.authorWilsgaard, Tom
dc.date.accessioned2023-08-30T07:28:17Z
dc.date.available2023-08-30T07:28:17Z
dc.date.issued2023-03-15
dc.description.abstractIntroduction: Freezing Cold Injuries (FCI) have been associated with long-term sequelae including vasospasm. The aims of the pilot study are to explore the research methodology and investigate the tolerability and safety of treatment with Botulinum Toxin-A (BTX-A) in FCI Sequelae. Methodology: This pilot study tests the logistics, the treatment setting and the follow-up procedure in an early-phase, double-blinded, randomized, controlled trial study-design. The variables in the study were subjective symptoms, peripheral micro-vascularization/rewarming, somatosensory responsiveness, and generic measure of health status. Results: No major challenges or difficulties were noticed according to the protocol or the study methodology. The monitoring of tolerability and safety of treatment with BTX-A did not reveal any major unwanted and/or adverse reactions among the patients in the pilot study and no challenges occurred during data collection of endpoints. The study revealed an inaccuracy of the 2nd degree FCI diagnosis and uncover a need for relevant and sufficient clinical information for FCI classification. Conclusions: This pilot study showed the study methodology with minor adjustments is feasible in a future full-scale clinical trial. The recruitment process needs to be more refined to ensure that the eligible study participants are a homogenous group of FCI patients.en_US
dc.identifier.citationNorheim, Borud, Mercer, de Weerd, Weiss, Wilsgaard. Botulinum Toxin A in the treatment of frostbite sequelae–results from a blinded, early-phase, comparative trial. International Journal of Circumpolar Health. 2023;82:1-10en_US
dc.identifier.cristinIDFRIDAID 2138867
dc.identifier.doi10.1080/22423982.2023.2189556
dc.identifier.issn1239-9736
dc.identifier.issn2242-3982
dc.identifier.urihttps://hdl.handle.net/10037/30522
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalInternational Journal of Circumpolar Health
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleBotulinum Toxin A in the treatment of frostbite sequelae–results from a blinded, early-phase, comparative trialen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)