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dc.contributor.authorZhang, Xiao-wen
dc.contributor.authorLi, Jing
dc.contributor.authorHou, Wen-bin
dc.contributor.authorJiang, Yue
dc.contributor.authorZheng, Ruo-xiang
dc.contributor.authorXu, De-hao
dc.contributor.authorShen, Chen
dc.contributor.authorRobinson, Nicola
dc.contributor.authorLiu, Jianping
dc.date.accessioned2023-09-04T06:48:42Z
dc.date.available2023-09-04T06:48:42Z
dc.date.issued2022-12-23
dc.description.abstractBackground: To explore the effectiveness and safety of Chinese herbal medicine (CHM) for drug-induced liver injury (DILI) in patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS).<p> <p>Methods: A systematic search was made of eight databases (Pubmed, Cochrane Library, Web of Science, Embase, CNKI, Wanfang, VIP, Sinomed) and two trial registries (WHO ICTRP, ClinicalTrials.gov) from inception to September 2022. The effect size was presented as risk ratio (RR) or mean difference (MD) with their 95% confidence interval (CI). The Cochrane Risk of Bias and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tools were used for quality appraisal. <p>Results: Ten randomized controlled trials (RCTs) involving 732 participants were included. Comparing CHM alone with routine treatment, the CHM group showed lower aspartate aminotransferase (MD=-11.47 U/L, 95%CI[-13.05, -9.89], low certainty), lower alanine aminotransferase (MD=-2.68 U/L, 95%CI[-4.27, - 1.08], low certainty), lower total bilirubin (MD=-4.31 mmol/L, 95%CI[-5.66, -2.96], low certainty), lower bilirubin direct (MD=-3.19 mmol/L, 95%CI[-3.87, -2.51], low certainty), and higher effective rate (assessed by symptoms and liver indicators) (RR=1.13, 95%CI[1.06, 1.20], low certainty). A significant difference was also found in CHM plus routine treatment versus routine treatment in the previous outcomes. No significant difference was found on helper T cells among these comparisons. Only one RCT reported safety of CHM and found no adverse reaction during the trial. <p>Conclusions: CHM may improve the liver function indices and effective rate for HIV/AIDS patients with DILI. However, the sample size was small and quality was low. Larger-samples of high-quality trials are needed.en_US
dc.identifier.citationZhang, Li, Hou, Jiang, Zheng, Xu, Shen, Robinson, Liu. Chinese herbal medicine for drug-induced liver injury in patients with HIV/AIDS: A systematic review of randomized controlled trials. Integrative Medicine Research (IMR). 2023;12(1)en_US
dc.identifier.cristinIDFRIDAID 2138510
dc.identifier.doi10.1016/j.imr.2022.100918
dc.identifier.issn2213-4220
dc.identifier.issn2213-4239
dc.identifier.urihttps://hdl.handle.net/10037/30642
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalIntegrative Medicine Research (IMR)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleChinese herbal medicine for drug-induced liver injury in patients with HIV/AIDS: A systematic review of randomized controlled trialsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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