dc.description.abstract | Background: To explore the effectiveness and safety of Chinese herbal medicine (CHM) for drug-induced
liver injury (DILI) in patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS).<p>
<p>Methods: A systematic search was made of eight databases (Pubmed, Cochrane Library, Web of Science,
Embase, CNKI, Wanfang, VIP, Sinomed) and two trial registries (WHO ICTRP, ClinicalTrials.gov) from inception to September 2022. The effect size was presented as risk ratio (RR) or mean difference (MD) with
their 95% confidence interval (CI). The Cochrane Risk of Bias and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tools were used for quality appraisal.
<p>Results: Ten randomized controlled trials (RCTs) involving 732 participants were included. Comparing
CHM alone with routine treatment, the CHM group showed lower aspartate aminotransferase (MD=-11.47
U/L, 95%CI[-13.05, -9.89], low certainty), lower alanine aminotransferase (MD=-2.68 U/L, 95%CI[-4.27, -
1.08], low certainty), lower total bilirubin (MD=-4.31 mmol/L, 95%CI[-5.66, -2.96], low certainty), lower
bilirubin direct (MD=-3.19 mmol/L, 95%CI[-3.87, -2.51], low certainty), and higher effective rate (assessed
by symptoms and liver indicators) (RR=1.13, 95%CI[1.06, 1.20], low certainty). A significant difference was
also found in CHM plus routine treatment versus routine treatment in the previous outcomes. No significant difference was found on helper T cells among these comparisons. Only one RCT reported safety of
CHM and found no adverse reaction during the trial.
<p>Conclusions: CHM may improve the liver function indices and effective rate for HIV/AIDS patients with
DILI. However, the sample size was small and quality was low. Larger-samples of high-quality trials are
needed. | en_US |
dc.identifier.citation | Zhang, Li, Hou, Jiang, Zheng, Xu, Shen, Robinson, Liu. Chinese herbal medicine for drug-induced liver injury in patients with HIV/AIDS: A systematic review of randomized controlled trials. Integrative Medicine Research (IMR). 2023;12(1) | en_US |