Institutt for klinisk medisin: Recent submissions

Now showing items 101-120 of 1974

    • miR-371a-3p Predicting Viable Tumor in Patients Undergoing Retroperitoneal Lymph Node Dissection for Metastatic Testicular Cancer: The SWENOTECA-MIR Study 

      Thor, Anna; Myklebust, Mette Pernille; Bergdahl, Anna Grenabo; Lundgren, Per-Olof; Skokic, Viktor; Almås, Bjarte; Haugnes, Hege Sagstuen; Tandstad, Torgrim; Akre, Olof; Cohn-Cedermark, Gabriella; Dahl, Olav; Kjellman, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)
      Purpose: The SWENOTECA-MIR prospective multicenter study aims to assess the clinical value of miR-371a-3p as a novel marker in metastatic germ cell tumor patients undergoing retroperitoneal lymph node dissection (RPLND), to predict the presence of viable residual tumor.<p> <p>Materials and Methods: A total of 114 patients (86 nonseminomas, 28 seminomas) who underwent surgery for presumed metastatic ...

    • Iohexol plasma clearance measurement protocol standardization for adults: a consensus paper of the European Kidney Function Consortium 

      Ebert, Natalie; Schaeffner, Elke; Seegmiller, Jesse C.; van Londen, Marco; Bökenkamp, Arend; Cavalier, Etienne; Delanaye, Pierre; Derain-Dubourg, Laurence; Eriksen, Bjørn Odvar; Indridason, Olafur S.; Palsson, Runolfur; Shafi, Tariq; Christensson, Anders; Bevc, Sebastjan; Carrara, Fabiola; Courbebaisse, Marie; Dalton, R. Neil; van der Giet, Markus; Melsom, Toralf; Methven, Shona; Nordin, Gunnar; Pottel, Hans; Rule, Andrew D.; Trillini, Matias; White, Christine A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-07)
      International consensus supports the development of standardized protocols for measured glomerular filtration rate (mGFR) to facilitate the integration of mGFR testing in both clinical and research settings. To this end, the European Kidney Function Consortium convened an international group of experts with relevant experience in mGFR. The working group performed an extensive literature search to ...

    • Antibiotic exposure for culture-negative early-onset sepsis in late-preterm and term newborns: an international study 

      Dimopoulou, Varvara; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; el Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K. A.; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nicola; Mózes, Enikő; Størdal, Ketil; Strunk, Tobias; Stocker, Martin; Giannoni, Eric; Aleksandra, Zwijacz; Kristyna, Zilinska; Martin, Trefny; Stensvold, Hans Jørgen; Damber, Shrestha; Rønnestad, Arild Erland; Vittoria, Rizzo; Frida, Oldendorff; Anne-Louise, Kollegger; Sharandeep, Kaur; Stellan, Håkansson; Bartłomiej, Grochowski; Carmelo, Geraci; Alessandra, Foglianese; Rana, Esmaeilizand; Zoe, el Helou; Khalyane, Eap; Pietro, Drimaco; Morena, De Angelis; Martina, Ceccoli; Grazia, Capretti Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-17)
      Background - Early-life antibiotic exposure is disproportionately high compared to the burden of culture-proven early-onset sepsis (CP-EOS). We assessed the contribution of culture-negative cases to the overall antibiotic exposure in the first postnatal week.<p> <p>Methods - We conducted a retrospective analysis across eleven countries in Europe, North America, and Australia. All late-preterm and ...

    • Patients with axial spondyloarthritis reported willingness to use remote care and showed high adherence to electronic patient-reported outcome measures: an 18-month observational study 

      Thomassen, Emil E. Kvernberg; Berg, Inger Jorid; Kristianslund, Eirik; Tveter, Anne Therese; Bakland, Gunnstein; Gossec, Laure; Hakim, Sarah; Macfarlane, Gary John; de Thurah, Annette; Østerås, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-21)
      Remote monitoring using electronic patient reported outcomes (ePROs) in axial spondyloarthritis (axSpA) may improve self-management and reduce the need for consultations. However, knowledge regarding patients’ willingness to use remote care and adherence to reporting ePROs is scarce. The objective of this study was to assess axSpA patients’ willingness to use remote care and adherence to reporting ...

    • ESR Essentials: imaging of suspected child abuse—practice recommendations by the European Society of Paediatric Radiology 

      Colleran, Gabrielle C.; Fossmark, Maria Olsen; Rosendahl, Karen; Argyropoulou, Maria; Mankad, Kshitij; Offiah, Amaka C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-18)
      The goal of this paper is to provide a useful desktop reference for the imaging of suspected child abuse with clear, age-specific pathways for appropriate evidence-based imaging and follow-up.<p> <p>We aim to provide a road map for the imaging evaluation and follow-up of this important and vulnerable cohort of patients presenting with signs and symptoms concerning for inflicted injury. As the ...

    • α1-Antichymotrypsin Complex (SERPINA3) Is an Independent Predictor of All-Cause but Not Cardiovascular Mortality in Patients Hospitalized for Chest Pain of Suspected Coronary Origin 

      Nilsen, Dennis WT; Aarsetøy, Reidun; Pønitz, Volker; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Andersen, Trygve Brugger; Staines, Harry; Grundt, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-25)
      Introduction: SERPINA3 is an acute phase protein triggered by inflammation. It is upregulated after an acute myocardial infarction (AMI). Data on its long-term prognostic value in MI patients are scarce. We aimed to assess the utility of SERPINA3 as a prognostic marker in patients hospitalized for chest pain of suspected coronary origin. Methods: A total of 871 consecutive patients, 386 diagnosed ...

    • The NORwegian atrial fibrillation self-SCREENing (NORSCREEN) trial: rationale and design of a randomized controlled trial 

      Boskovic, Miroslav; Jortveit, Jarle; Haraldsen, Marius Blørstad; Berge, Trygve; Engdahl, Johan; Løchen, Maja-Lisa; Schuster, Peter Moritz; Sandberg, Edvard Liljedahl; Grimsmo, Jostein; Atar, Dan; Anfinsen, Ole-Gunnar; Pripp, Are Hugo; Grenne, Bjørnar Leangen; Halvorsen, Sigrun (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-09)
      Aims Atrial fibrillation (AF) is a common arrhythmia, and many cases of AF may be undiagnosed. Whether screening for AF and subsequent treatment if AF is detected can improve long-term outcome remains an unsettled question. The primary aim of the NORwegian atrial fibrillation self-SCREENing (NORSCREEN) trial is to assess whether self-screening for AF with continuous electrocardiogram (ECG) for 3–7 ...

    • Health-Related Quality of Life in FKRP-Related Limb-Girdle Muscular Dystrophy R9 

      Jensen, Synnøve M; Friborg, Oddgeir; Mellgren, Svein Ivar; Müller, Kai Ivar; Bergvik, Svein Hugo; Arntzen, Kjell Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-02)
      Background: Limb-girdle muscular dystrophy R9 (LGMDR9) is a chronic progressive hereditary muscle disease, related to the Fukutin Related Protein (FKRP) gene, that may cause major disabilities, cardiomyopathy, and ventilatory failure. Knowledge of how LGMDR9 affects health-related quality of life (HRQoL) is relevant in treatment and care.<p> <p>Objective: To investigate HRQoL in the Norwegian ...

    • Functional outcome and associations with prehospital time and urban-remote disparities in trauma: A Norwegian national population-based study 

      Nilsbakken, Inger Marie Waal; Wisborg, Torben; Sollid, Stephen J. M.; Jeppesen, Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-05)
      Background - There is a lack of knowledge regarding the functional outcomes of patients after trauma. Remote areas in Norway has been associated with an increased risk of trauma-related mortality. However, it is unknown how this might influence trauma-related morbidity. The aim of this study was to assess the functional outcomes of patients in the Norwegian trauma population and the relationship ...

    • Initial surveillance in men with marker negative clinical stage IIA non-seminomatous germ cell tumours 

      Gerdtsson, Axel; Negaard, Helene Francisca Stigter; Almås, Bjarte; Bergdahl, Anna Grenabo; Cohn-Cedermark, Gabriella; Glimelius, Ingrid; Halvorsen, Dag; Haugnes, Hege Sagstuen; Hedlund, Annika; Hellström, Martin; Holmberg, Göran; Karlsdottir, Åsa; Kjellman, Anders; Larsen, Signe Melsen; Thor, Anna; Wahlqvist, Rolf; Ståhl, Olof; Tandstad, Torgrim (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-31)
      Objectives - To assess whether extended surveillance with repeated computed tomography (CT) scans for patients with clinical stage IIA (CS IIA; <2 cm abdominal node involvement) and negative markers (Mk−) non-seminomatous germ cell tumours (NSGCTs) can identify those with true CS I. To assess the rate of benign lymph nodes, teratoma, and viable cancer in retroperitoneal lymph node dissection (RPLND) ...

    • Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients 

      Barratt-Due, Andreas; Pettersen, Kristin; Dahl, Tuva Børresdatter; Holter, Jan Cato; Grønli, Renathe Henriksen; Dyrhol-Riise, Anne Ma; Lerum, Tøri Vigeland; Holten, Aleksander Rygh; Tonby, Kristian; Trøseid, Marius; Skjønsberg, Ole Henning; Granerud, Beathe Kiland; Heggelund, Lars; Kildal, Anders Benjamin; Schjalm, Camilla; Aaløkken, Trond Mogens; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-27)
      Background. The complement system, an upstream recognition system of innate immunity, is activated upon SARS-CoV-2 infection. To gain a deeper understanding of the extent and duration of this activation, we investigated complement activation profiles during the acute phase of COVID-19, its persistence post-recovery and dynamic changes in relation to disease severity.<p> <p>Methods. Serial ...

    • Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants 

      Glaser, Kirsten; Härtel, Christoph; Klingenberg, Claus Andreas; Herting, Egbert; Fortmann, Mats I.; Speer, Christian P.; Stensvold, Hans Jørgen; Huncikova, Zuzana; Rønnestad, Arild Erland; Nentwich, Martin M.; Stahl, Andreas; Dammann, Olaf; Göpel, Wolfgang (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-25)
      Importance - Retinopathy of prematurity (ROP) is a major morbidity of preterm infants causing visual impairment, including blindness, for which timely treatment is vital and prevention is key. Increasing evidence suggests that exposure to neonatal sepsis contributes to ROP development.<p> <p>Objective - To investigate the association between neonatal sepsis and ROP in 2 large-scale cohorts of ...

    • One-stage implant in sacral neuromodulation for faecal incontinence – short-term outcome from a prospective study 

      Duelund-Jakobsen, Jakob; Buntzen, Steen; Lundby, Lilli; Laurberg, Søren; Sørensen, Michael; Rydningen, Mona Birgitte (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-11)
      Aim: Sacral neuromodulation (SNM) is approved for the treatment of faecal incontinence (FI) in a two-stage technique. With standardized implantation, approximately 90% of pa tients undergo successful Stage I operation and proceed to a permanent implant (Stage II). The aim of this work was to explore the feasibility of SNM as a one-stage procedure and report the 24-week efficacy.<p> <p>Method: ...

    • Upper gastrointestinal endoscopy in the surgically altered patient 

      Bhat, Purnima; Kaffes, Arthur John; Lassen, Kristoffer; Aabakken, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-01)
      As management of upper gastrointestinal malignancies improves, and with popularization of bariatric surgery, endoscopists are likely to meet patients with altered upper gastrointestinal anatomy. Short-term, the surgery can cause complications like bleeding, leaks, and fistulas, and longer-term problems such as intestinal or biliary anastomotic strictures or biliary stones can arise, all ...

    • PALLiative care in ONcology (PALLiON): A cluster-randomised trial investigating the effect of palliative care on the use of anticancer treatment at the end of life 

      Hjermstad, Marianne Jensen; Pirnat, Aleksandra; Aass, Nina Kathrine; Andersen, Sigve; Astrup, Guro Lindviksmoen; Dajani, Olav; Garresori, Herish; Guldhav, Kristin Vassbotn; Hamre, Hanne Mari; Haukland, Ellinor Christin; Jordal, Frode; Lundeby, Tonje; Løhre, Erik Torbjørn; Mjåland, Svein; Paulsen, Ørnulf; Semb, Karin; Staff, Erik Schistad; Wester, Torunn Elin; Kaasa, Stein (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-09)
      Background: Effects on anticancer therapy following the integration of palliative care and oncology are rarely investigated. Thus, its potential effect is unknown.<p> <p>Aim: To investigate the effects of the complex intervention PALLiON versus usual care on end-of-life anticancer therapy.<p> <p>Design: Cluster-randomised controlled trial (RCT), registered at ClinicalTrials.gov (No. NCT01362816). ...

    • Stable glioma incidence and increased patient survival over the past two decades in Norway: a nationwide registry-based cohort study 

      Skaga, Erlend; Trewin-Nybråten, Cassia Bree; Niehusmann, Pitt; Johannessen, Tom Børge; Marienhagen, Kirsten; Oltedal, Leif; Schipmann, Stephanie; Skjulsvik, Anne Jarstein; Solheim, Ole Skeidsvoll; Solheim, Tora S; Sundstrøm, Terje; Vik-Mo, Einar Osland; Brandal, Petter; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-19)
      Background: Surveillance of incidence and survival of central nervous system tumors is essential to monitor disease burden and epidemiological changes, and to allocate health care resources. Here, we describe glioma incidence and survival trends by histopathology group, age, and sex in the Norwegian population.<p> <p>Material and methods: We included patients with a histologically verified glioma ...

    • Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study 

      Støyten, Martin; Knutsen, Tore; Stikbakke, Einar; Agledahl, Ingvild; Wilsgaard, Tom; Eggen, Anne Elise; Richardsen, Elin Helmine; Giovannucci, Edward; Thune, Inger; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-09)
      Background: Studies of excess weight and weight changes throughout adult life for prostate cancer (PCa) risk and prognosis have shown inconsistent results.<p> <p>Methods: In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), 16,960 healthy men from the prospective cohort Tromsø Study (1994–2016) were included. Body mass index (BMI) and weight were measured at all ...

    • Male patients with inflammatory joint diseases are less likely than controls to be childless: Results from a Norwegian population-based cohort study of 10 865 patients 

      Sigmo, Gudrun David; Hauge, Solveig; Hufthammer, Karl Ove; Wallenius, Marianne; Salvesen, Kjell Åsmund Blix; Daltveit, Anne Kjersti Nesje; Bakland, Gunnstein; Fevang, Bjørg Tilde Svanes (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-12)
      Objectives To investigate the number of children per man and the proportion of childless men as a proxy of fertility in a national cohort of men with inflammatory joint diseases (IJDs), compared with matched controls from the general population.<p> <p>Methods This is a nationwide, population-based retrospective cohort study. Male patients with IJDs (n = 10 865) in the Norwegian Arthritis ...

    • Histomolecular Validation of [18F]-FACBC in Gliomas Using Image-Localized Biopsies 

      Vindstad, Benedikte Emilie; Skjulsvik, Anne Jarstein; Pedersen, Lars Kjelsberg; Berntsen, Erik Magnus; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Reinertsen, Ingerid; Johansen, Håkon; Eikenes, Live; Karlberg, Anna Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-18)
      Background: Gliomas have a heterogeneous nature, and identifying the most aggressive parts of the tumor and defining tumor borders are important for histomolecular diagnosis, surgical resection, and radiation therapy planning. This study evaluated [<sup>18</sup>F]-FACBC PET for glioma tissue classification. Methods: Pre-surgical [<sup>18</sup>F]-FACBC PET/MR images were used during surgery ...

    • Lung cancer reirradiation: Exploring modifications to utilization, treatment modalities and factors associated with outcomes 

      Gullhaug, Anna; Haakensen, Vilde Drageset; De Ruysscher, Dirk; Simone, Charles B.; Hotca-Cho, Alexandra E.; Chhabra, Arpit M.; Hellebust, Taran Annette Paulsen; Paulsen, Erna-Elise; Dimopoulos, Maria P.; Johansen, Safora (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-29)
      Background: Patients treated for lung cancer (LC) often experience locoregional failure after initial treatment. Due to technological advances, thoracic reirradiation (re-RT) has become a viable treatment option. We sought to investigate the use of thoracic re-RT in LC patients over a time period characterized by technological advances in a large, multi-center cohort.<p> <p>Methods and materials: ...