Viser treff 81-100 av 1799

    • Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study 

      Sævik, Åse Bjorvatn; Ueland, Grethe Åstrøm; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Höybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Kämpe, Olle; Bensing, Sophie; Husebye, Eystein Sverre; Øksnes, Marianne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-09)
      Objective - Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood.<p> <p<Design - Cross-sectional study.<p> <p>Methods - We compared serum levels of 177 cardiovascular and inflammatory biomarkers in 43 patients with AAD at >18-h glucocorticoid withdrawal and 43 matched controls, overall and stratified ...
    • GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification 

      Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; González, Karla Sofia Gutiérrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Mägi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, Ηe; Εvangelou, Εvangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Müller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Corrêa, Ivan R.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, André G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir Lingaas; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Inês; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njølstad, Inger; Wichmann, H.-Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josée; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-07)
      Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without ...
    • Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials 

      Al-Shahi Salman, Rustam; Stephen, Jacqueline; Tierney, Jayne F; Lewis, Steff C; Newby, David E; Parry-Jones, Adrian R; White, Philip M; Connolly, Stuart J; Benavente, Oscar R; Dowlatshahi, Dar; Cordonnier, Charlotte; Viscoli, Catherine M; Sheth, Kevin N; Kamel, Hooman; Veltkamp, Roland; Larsen, Kristin Tveitan; Hofmeijer, Jeannette; Kerkhoff, Henk; Schreuder, Floris H B M; Shoamanesh, Ashkan; Klijn, Catharina J M; van der Worp, H Bart; Song, Lili; Wyller, Torgeir Bruun; Rønning, Ole Morten; Ihle-Hansen, Hege Beathe; Sandset, Else Charlotte; Carlsson, Maria Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
      Background - The safety and efficacy of oral anticoagulation for prevention of major adverse cardiovascular events in people with atrial fibrillation and spontaneous intracranial haemorrhage are uncertain. We planned to estimate the effects of starting versus avoiding oral anticoagulation in people with spontaneous intracranial haemorrhage and atrial fibrillation.<p> <p>Methods - In this prospective ...
    • Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score 

      De Winter, Maria A.; Büller, Harry R.; Carrier, Marc; Cohen, Alexander T.; Hansen, John Bjarne; Kaasjager, Karin A. H.; Kakkar, Ajay K.; Middeldorp, Saskia; Raskob, Gary E.; Sørensen, Henrik T.; Visseren, Frank L. J.; Wells, Philip S.; Dorresteijn, Jannick A. N.; Nijkeuter, Mathilde; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-17)
      Aims Deciding to stop or continue anticoagulation for venous thromboembolism (VTE) after initial treatment is challenging, as individual risks of recurrence and bleeding are heterogeneous. The present study aimed to develop and externally validate models for predicting 5-year risks of recurrence and bleeding in patients with VTE without cancer who completed at least 3 months of initial treatment, ...
    • Description of the prehospital emergency healthcare system in Norway 

      Kjærvoll, Hege K.; Andersson, Lars-Jøran; Bakkelund, Karin Elvenes; Harring, Astrid Karina V.; Tjelmeland Myrhaugen, Ingvild Beathe (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-23)
      Background: Norway has a long coastline, steep mountains, and wide fjords, which presents some challenges to the prehospital emergency healthcare system. In recent years, the prehospital emergency medical services (EMS) have undergone significant changes, structurally, in terms of professionalisation of the services and in the education level of the personnel. In this article, we aim to describe ...
    • Oral health-related quality of life, impaired physical health and orofacial pain in children and adolescents with juvenile idiopathic arthritis – a prospective multicenter cohort study 

      Halbig, Josefine Mareile; Jönsson, Birgitta; Gil, Elisabeth Grut; Åstrøm, Anne-Kristine N; Rypdal, Veronika Gjertsen; Frid, Paula Hanna Therese; Augdal, Thomas Angell; Fischer, Johannes Maria; Cetrelli, Lena Elisabet; Rygg, Marite; Lundestad, Anette; Tylleskär, Karin Birgitta; Nordal, Ellen Berit (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)
      Background - Knowledge on oral health-related quality of life (OHRQoL) in children and adolescents with juvenile idiopathic arthritis (JIA) is limited, and longitudinal studies are lacking. We aimed to describe OHRQoL in children and adolescents with JIA compared to controls, and to explore the validity and internal consistency of the Early Childhood Oral Health Impact Scale (ECOHIS) and the Child ...
    • The Association Between Metabolic Syndrome, Hyperfiltration, and Long-Term GFR Decline in the General Population 

      Bystad, Erikka Wikan; Stefansson, Vidar Tor Nyborg; Eriksen, Bjørn Odvar; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-01)
      Introduction: One-quarter of adults worldwide meet the criteria of metabolic syndrome (MetS). MetS increases the risk of diabetes, chronic kidney disease (CKD), and cardiovascular disease. However, the association between MetS, hyperfiltration, and long-term glomerular filtration rate (GFR) decline in the general population is unknown.<p> <p>Methods: In the Renal Iohexol Clearance Survey (RENIS), ...
    • Reducing unwarranted variation: can a ‘clinical dashboard’ be helpful for hospital executive boards and top-level leaders? 

      Tjomsland, Ole; Thoresen, Christian; Ingebrigtsen, Tor; Søreide, Eldar; Frich, Jan C (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)
      Background/aim: In the past decades, there has been an increasing focus on defining, identifying and reducing unwarranted variation in clinical practice. There have been several attempts to monitor and reduce unwarranted variation, but the experience so far is that these initiatives have failed to reach their goals. In this article, we present the initial process of developing a safety, quality and ...
    • Validation of forearm fracture diagnoses in administrative patient registers 

      Omsland, Tone Kristin; Solberg, Lene Bergendal; Bjørnerem, Åshild Marit; Borgen, Tove Tveitan; Andreasen, Camilla; Wisløff, Torbjørn; Hagen, Gunhild; Basso, Trude; Gjertsen, Jan-Erik; Apalset, Ellen Margrete; Figved, Wender; Stutzer, Jens-Meinhard; Nissen, Frida Igland; Hansen, Ann Kristin; Joakimsen, Ragnar Martin; Figari, Elisa; Peel, Geoffrey; Rashid, Ali A.; Khoshkhabari, Jashar; Eriksen, Erik Fink; Nordsletten, Lars; Frihagen, Frede; Dahl, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)
      Summary The validity of forearm fracture diagnoses recorded in fve Norwegian hospitals was investigated using image reports and medical records as gold standard. A relatively high completeness and correctness of the diagnoses was found. Algorithms used to define forearm fractures in administrative data should depend on study purpose.<p> <p>Purpose In Norway, forearm fractures are routinely recorded ...
    • The Norwegian registry for spine surgery (NORspine): cohort profile 

      Mikkelsen, Eirik; Ingebrigtsen, Tor; Thyrhaug, Anette Moltu; Olsen, Lena Ringstad; Nygaard, Øystein Petter; Austevoll, Ivar Magne; Brox, Jens Ivar; Hellum, Christian; Kolstad, Frode; Lønne, Greger; Solberg, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-17)
      Purpose - To review and describe the development, methods and cohort of the lumbosacral part of the Norwegian registry for spine surgery (NORspine).<p> <p>Methods - NORspine was established in 2007. It is government funded, covers all providers and captures consecutive cases undergoing operations for degenerative disorders. Patients’ participation is voluntary and requires informed consent. A set ...
    • Diagnostic accuracy of anti-3-[<sup>18</sup>F]-FACBC PET/MRI in gliomas 

      Karlberg, Anna Maria; Pedersen, Lars Kjelsberg; Vindstad, Benedikte Emilie; Skjulsvik, Anne Jarstein; Johansen, Håkon; Solheim, Ole Skeidsvoll; Skogen, Karoline; Kvistad, Kjell Arne; Bogsrud, Trond; Myrmel, Kristin Smistad; Giskeødegård, Guro F.; Ingebrigtsen, Tor; Berntsen, Erik Magnus; Eikenes, Live (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-30)
      Purpose - The primary aim was to evaluate whether anti-3-[<sup>18</sup>F]FACBC PET combined with conventional MRI correlated better with histomolecular diagnosis (reference standard) than MRI alone in glioma diagnostics. The ability of anti-3-[<sup>18</sup>F]FACBC to differentiate between molecular and histopathological entities in gliomas was also evaluated.<p> <p>Methods - In this prospective ...
    • Baseline Demographics, Comorbidities, Treatment Patterns and Burden of Atopic Dermatitis in Adults and Adolescents from the GLOBOSTAD Long-Term Observational Study 

      Calzavara-Pinton, Piergiacomo; Čelakovská, Jarmila; Lapeere, Hilde; Holzer, Gregor; Al-Ahmad, Mona; Chu, Chia-Yu; Ferrucci, Silvia M.; Kataoka, Yoko; Rossi, Mariateresa; Fomina, Daria S.; Chung, Wen-Hung; Tzellos, Thrasyvoulos; Fougerousse, Anne-Claire; Wu, Jiangming; Ardeleanu, Marius; Ozturk, Zafer E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-06)
      Introduction - Insights into real-world treatment of atopic dermatitis (AD) are relevant to clinical decision making. The aim of this analysis was to characterize patients who receive dupilumab for AD in a real-world setting.<p> <p>Methods - The GLOBOSTAD registry is an ongoing, longitudinal, prospective, observational study of patients with AD who receive dupilumab according to country-specific ...
    • Prospective randomized clinical studies involving reirradiation: update of a systematic review 

      Nieder, Carsten; Willmann, Jonas; Andratschke, Nicolaus H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-27)
      Background Reirradiation is a potentially useful option for many patients with recurrent cancer, aiming at cure or symptom palliation, depending on disease/recurrence type and stage. The purpose of this follow-up study to a previous review from 2016 was to summarize all recently published randomized trials. Points of interest again included identifcation of methodological strengths and weaknesses, ...
    • Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis 

      Hudson, Jemma; Cruickshank, Moira; Quinton, Richard; Aucott, Lorna; Wu, Frederick; Grossmann, Mathis; Bhasin, Shalender; Snyder, Peter J; Ellenberg, Susan S; Travison, Thomas G; Brock, Gerald B; Gianatti, Emily J; van der Schouw, Yvonne T; Emmelot-Vonk, Marielle H; Giltay, Erik J; Hackett, Geoff; Ramachandran, Sudarshan; Svartberg, Johan; Hildreth, Kerry L; Antonic, Kristina Groti; Tenover, Joyce Lisa; Tan, Hui Meng; Ho Chee Kong, Christopher; Tan, Wei Shen; Marks, Leonard S; Ross, Richard J; Schwartz, Robert S; Manson, Paul; Roberts, Stephen A; Skovsager Andersen, Marianne; Velling Magnussen, Line; Aceves-Martins, Magaly; Gillies, Katie; Hernández, Rodolfo; Oliver, Nick; Dhillo, Waljit S; Bhattacharya, Siladitya; Brazzelli, Miriam; Jayasena, Channa N (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-04)
      Background Testosterone replacement therapy is known to improve sexual function in men younger than 40 years with pathological hypogonadism. However, the extent to which testosterone alleviates sexual dysfunction in older men and men with obesity is unclear, despite the fact that testosterone is being increasingly prescribed to these patient populations. We aimed to evaluate whether subgroups of men ...
    • Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Walby, Fredrik A; Myhre, Martin Øverlien; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
      Background: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients.<p> <p>Patients and Methods: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) ...
    • Pregnant Women at Low Risk of Having a Child with Fetal and Neonatal Alloimmune Thrombocytopenia Do Not Require Treatment with Intravenous Immunoglobulin 

      Kjeldsen-Kragh, Jens; Bein, Gregor; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)
      Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition in which maternal alloantibodies to fetal platelets cause fetal thrombocytopenia that may lead to intracranial hemorrhage (ICH). Off-label intravenous immunoglobulin (IVIg) has for 30 years been the standard of care for pregnant women who previously have had a child with FNAIT. The efficacy of this treatment has never ...
    • Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies 

      Marsh, Phillip L.; Moore, Ernest E.; Moore, Hunter B.; Bunch, Connor M.; Aboukhaled, Michael; Condon, Shaun M.; Al-Fadhl, Mahmoud D.; Thomas, Samuel J.; Larson, John R.; Bower, Charles W.; Miller, Craig B.; Pearson, Michelle L.; Twilling, Christopher L.; Reser, David W.; Kim, George S.; Troyer, Brittany M.; Yeager, Doyle; Thomas, Scott G.; Srikureja, Daniel P.; Patel, Shivani S.; Añón, Sofía L.; Thomas, Anthony V.; Miller, Joseph B.; Van Ryn, David E.; Pamulapati, Saagar V.; Zimmerman, Devin; Wells, Byars; Martin, Peter L.; Seder, Christopher W.; Aversa, John G.; Greene, Ryan B.; March, Robert J.; Kwaan, Hau C.; Fulkerson, Daniel H.; Vande Lune, Stefani A.; Mollnes, Tom Eirik; Nielsen, Erik Waage; Stage Storm, Benjamin; Walsh, Mark M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-19)
      Iatrogenic vascular air embolism is a relatively infrequent event but is associated with significant morbidity and mortality. These emboli can arise in many clinical settings such as neurosurgery, cardiac surgery, and liver transplantation, but more recently, endoscopy, hemodialysis, thoracentesis, tissue biopsy, angiography, and central and peripheral venous access and removal have overtaken surgery ...
    • Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study 

      Meknas, Dana; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-20)
      Background Surgery is a major transient risk factor for venous thromboembolism (VTE). However, the impact of major surgery as a VTE trigger has been scarcely investigated using a case-crossover design.<p> <p>Aim To investigate the role of major surgery as a trigger for incident VTE in a population-based case-crossover study while adjusting for other concomitant VTE triggers. <p>Methods We ...
    • The temporal association between suicide and comorbid mental disorders in people treated for substance use disorders: a National registry study 

      Myhre, Martin Øverlien; Walby, Fredrik A; Bramness, Jørgen Gustav; Mehlum, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-11)
      Background The time after contact with specialized health services for mental health and substance use is associated with an increased risk of suicide, where temporal aspects of suicide and comorbid mental disorders in patients with substance use disorders could be associated. This study aimed to examine the temporal association between time from last treatment contact to suicide and comorbid ...
    • Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review 

      Wikan, Vårin Eiriksdatter; Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      (1) Background: The current diagnostic algorithm for acute pulmonary embolism (PE) is associated with the overuse of CT pulmonary angiography (CTPA). An additional highly specific blood test could potentially lower the proportion of patients with suspected PE that require CTPA. The aim was to summarize the literature on the diagnostic performance of biomarkers of patients admitted to an emergency ...