Institutt for klinisk medisin: Nye registreringer

Viser treff 61-80 av 1920

    • PALLiative care in ONcology (PALLiON): A cluster-randomised trial investigating the effect of palliative care on the use of anticancer treatment at the end of life 

      Hjermstad, Marianne Jensen; Pirnat, Aleksandra; Aass, Nina Kathrine; Andersen, Sigve; Astrup, Guro Lindviksmoen; Dajani, Olav; Garresori, Herish; Guldhav, Kristin Vassbotn; Hamre, Hanne Mari; Haukland, Ellinor Christin; Jordal, Frode; Lundeby, Tonje; Løhre, Erik Torbjørn; Mjåland, Svein; Paulsen, Ørnulf; Semb, Karin; Staff, Erik Schistad; Wester, Torunn Elin; Kaasa, Stein (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-09)
      Background: Effects on anticancer therapy following the integration of palliative care and oncology are rarely investigated. Thus, its potential effect is unknown.<p> <p>Aim: To investigate the effects of the complex intervention PALLiON versus usual care on end-of-life anticancer therapy.<p> <p>Design: Cluster-randomised controlled trial (RCT), registered at ClinicalTrials.gov (No. NCT01362816). ...

    • Stable glioma incidence and increased patient survival over the past two decades in Norway: a nationwide registry-based cohort study 

      Skaga, Erlend; Trewin-Nybråten, Cassia Bree; Niehusmann, Pitt; Johannessen, Tom Børge; Marienhagen, Kirsten; Oltedal, Leif; Schipmann, Stephanie; Skjulsvik, Anne Jarstein; Solheim, Ole Skeidsvoll; Solheim, Tora S; Sundstrøm, Terje; Vik-Mo, Einar Osland; Brandal, Petter; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-19)
      Background: Surveillance of incidence and survival of central nervous system tumors is essential to monitor disease burden and epidemiological changes, and to allocate health care resources. Here, we describe glioma incidence and survival trends by histopathology group, age, and sex in the Norwegian population.<p> <p>Material and methods: We included patients with a histologically verified glioma ...

    • Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study 

      Støyten, Martin; Knutsen, Tore; Stikbakke, Einar; Agledahl, Ingvild; Wilsgaard, Tom; Eggen, Anne Elise; Richardsen, Elin Helmine; Giovannucci, Edward; Thune, Inger; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-09)
      Background: Studies of excess weight and weight changes throughout adult life for prostate cancer (PCa) risk and prognosis have shown inconsistent results.<p> <p>Methods: In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), 16,960 healthy men from the prospective cohort Tromsø Study (1994–2016) were included. Body mass index (BMI) and weight were measured at all ...

    • Male patients with inflammatory joint diseases are less likely than controls to be childless: Results from a Norwegian population-based cohort study of 10 865 patients 

      Sigmo, Gudrun David; Hauge, Solveig; Hufthammer, Karl Ove; Wallenius, Marianne; Salvesen, Kjell Åsmund Blix; Daltveit, Anne Kjersti Nesje; Bakland, Gunnstein; Fevang, Bjørg Tilde Svanes (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-12)
      Objectives To investigate the number of children per man and the proportion of childless men as a proxy of fertility in a national cohort of men with inflammatory joint diseases (IJDs), compared with matched controls from the general population.<p> <p>Methods This is a nationwide, population-based retrospective cohort study. Male patients with IJDs (n = 10 865) in the Norwegian Arthritis ...

    • Histomolecular Validation of [18F]-FACBC in Gliomas Using Image-Localized Biopsies 

      Vindstad, Benedikte Emilie; Skjulsvik, Anne Jarstein; Pedersen, Lars Kjelsberg; Berntsen, Erik Magnus; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Reinertsen, Ingerid; Johansen, Håkon; Eikenes, Live; Karlberg, Anna Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-18)
      Background: Gliomas have a heterogeneous nature, and identifying the most aggressive parts of the tumor and defining tumor borders are important for histomolecular diagnosis, surgical resection, and radiation therapy planning. This study evaluated [<sup>18</sup>F]-FACBC PET for glioma tissue classification. Methods: Pre-surgical [<sup>18</sup>F]-FACBC PET/MR images were used during surgery ...

    • Lung cancer reirradiation: Exploring modifications to utilization, treatment modalities and factors associated with outcomes 

      Gullhaug, Anna; Haakensen, Vilde Drageset; De Ruysscher, Dirk; Simone, Charles B.; Hotca-Cho, Alexandra E.; Chhabra, Arpit M.; Hellebust, Taran Annette Paulsen; Paulsen, Erna-Elise; Dimopoulos, Maria P.; Johansen, Safora (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-29)
      Background: Patients treated for lung cancer (LC) often experience locoregional failure after initial treatment. Due to technological advances, thoracic reirradiation (re-RT) has become a viable treatment option. We sought to investigate the use of thoracic re-RT in LC patients over a time period characterized by technological advances in a large, multi-center cohort.<p> <p>Methods and materials: ...

    • Umbilical Cord pH Levels and Neonatal Morbidity and Mortality 

      Andersson, Charlotte Brix; Klingenberg, Claus Andreas; Thellesen, Line; Johnsen, Søren Paaske; Kesmodel, Ulrik Schiøler; Petersen, Jesper Padkaer (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-14)
      Importance Umbilical cord pH (UC-pH) level is an important objective indicator of intrapartum fetal hypoxia and is used to predict neonatal morbidity and mortality. A UC-pH value of less than 7.00 is often defined as a threshold for severe acidosis, but existing evidence is divergent and largely based on UC-pH measurements from selected populations; consequently, the results are challenging to ...

    • Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity 

      Mazagao Guerreiro, Eduarda; Kruglik, Sergei G.; Swamy, Samantha; Latysheva, Nadezhda; Østerud, Bjarne; Guigner, Jean-Michel; Sureau, Franck; Bonneau, Stephanie; Kuzmin, Andrey N.; Prasad, Paras N.; Hansen, John Bjarne; Hellesø, Olav Gaute; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-22)
      Background: Extracellular vesicles (EVs), in particular those derived from activated platelets, are associated with a risk of future venous thromboembolism. Objectives: To study the biomolecular profile and function characteristics of EVs from control (unstimulated) and activated platelets.<p> <p>Methods: Biomolecular profiling of single or very few (1-4) platelet-EVs (control/ stimulated) was ...

    • Performance of an Artificial Intelligence System for Breast Cancer Detection on Screening Mammograms from BreastScreen Norway 

      Larsen, Marthe; Olstad, Camilla Flåt; Lee, Christoph I.; Hovda, Tone; Hoff, Solveig Kristin Roth; Martiniussen, Marit Almenning; Mikalsen, Karl Øyvind; Lund-Hanssen, Håkon; Solli, Helene; Silberhorn, Marko; Sulheim, Åse Ø.; Auensen, Steinar Gøytil; Nygård, Jan Franz; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)
      A commercially available artificial intelligence system showed high performance in detecting breast cancers within 2 years of screening mammography and may help triage low-risk mammograms to reduce radiologist workload.<p> <p>Purpose - To explore the stand-alone breast cancer detection performance, at different risk score thresholds, of a commercially available artificial intelligence (AI) ...

    • Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size 

      Kindberg, Kristine Mørk; Broch, Kaspar; Andersen, Geir Øystein; Anstensrud, Anne Kristine; Åkra, Sissel; Woxholt, Sindre; Tøllefsen, Ingvild Maria; Ueland, Thor; Amundsen, Brage H.; Kløw, Nils-Einar; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Murphy, Sarah Louise Mikalsen; Damås, Jan Kristian; Opdahl, Anders; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Santos-Gallego, Carlos; Seljeflot, Ingebjørg; Stokke, Mathis Korseberg; Helseth, Ragnhild Merckoll (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-15)
      Background - Interleukin-6-receptor inhibition with tocilizumab improves myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI). Reduced levels of neutrophil extracellular traps (NETs), which consist of nuclear material studded with proteins released upon neutrophil activation, might contribute to this effect.<p> <p>Objectives - The purpose of this study was to ...

    • Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden 

      Nieder, Carsten; Johnsen, Silje Kristine; Winther, Annette M.; Mannsåker, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-26)
      Background Multimodal breast cancer treatment may cause side effects reflected in patient-reported outcomes and/or symptom scores at the time of treatment planning for adjuvant radiotherapy. In our department, all patients have been assessed with the Edmonton Symptom Assessment System (ESAS; a questionnaire addressing 11 major symptoms and wellbeing on a numeric scale of 0–10) at the time of ...

    • Effect of a low-carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial 

      Lundanes, Julianne; Sandnes, Frida Huhta; Gjeilo, Kari Hanne; Salater, Sissel; Alho Letra Martins, Catia Patricia; Nymo, Siren; Hanson, Patrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-16)
      Objective: The primary objective of this study was to evaluate the effect of a low-carbohydrate diet (LCD) compared with a control diet on pain in female patients with lipedema. The secondary objectives were to compare the impact of the two diets on quality of life (QoL) and investigate potential associations of changes in pain with changes in body weight, body composition, and ketosis.<p> <p>Methods: ...

    • Tumor versus Tumor Cell Targeting in Metal-Based Nanoparticles for Cancer Theranostics 

      Urbano-Gámez, Jesús David; Guzzi, Cinzia; Bernal, Manuel; Solivera, Juan; Martinez, Inigo Zubiavrre; Caro, Carlos; García-Martín, María Luisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-10)
      The application of metal-based nanoparticles (mNPs) in cancer therapy and diagnostics (theranostics) has been a hot research topic since the early days of nanotechnology, becoming even more relevant in recent years. However, the clinical translation of this technology has been notably poor, with one of the main reasons being a lack of understanding of the disease and conceptual errors in the design ...

    • Free Vascularized Fibula Graft as Primary Salvage Procedure for Acute Cervical Osteomyelitis Caused by Epidural Abscess 

      Ciosek, Timothy Allan; Sørlie, Andreas; Munch-Ellingsen, Jens; Solberg, Tore; Weum, Sven Magne; Weerd, Louis de (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-24)
      Acute cervical osteomyelitis due to an epidural abscess and pyogenic spondylodiscitis in an immunosuppressed patient with progressive myelopathy is a challenge for the reconstructive surgeon. This report presents our novel approach to treat such a condition in a 56-year-old patient in whom antibiotic treatment and decompression of the medulla by laminectomy of C4–C6 failed. Under general anesthesia, ...

    • The prognostic importance of traumatic axonal injury on early MRI: the Trondheim TAI-MRI grading and quantitative models 

      Moen, Kent Gøran; Flusund, Anne-Mari Holte; Moe, Hans Kristian; Andelic, Nada; Skandsen, Toril; Håberg, Asta; Kvistad, Kjell Arne; Olsen, Øystein E.; Saksvoll, Elin Hildrum; Abel-Grüner, Sebastian; Anke, Audny Gabriele Wagner; Follestad, Turid; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-19)
      Objectives We analysed magnetic resonance imaging (MRI) findings after traumatic brain injury (TBI) aiming to improve the grading of traumatic axonal injury (TAI) to better reflect the outcome.<p> <p>Methods Four-hundred sixty-three patients (8–70 years) with mild (n = 158), moderate (n = 129), or severe (n = 176) TBI and early MRI were prospectively included. TAI presence, numbers, and volumes ...

    • Status epilepticus in POLG disease: a large multinational study 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus Andreas; Rasmussen, Magnhild; Brodtkorb, Eylert; Ostergaard, Elsebet; de Coo, Irenaeus; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Majamaa, Kari; Kärppä, Mikko; Ortigoza-Escobar, Juan Dario; Tangeraas, Trine; Berland, Siren; Harrison, Emma; Biggs, Heather; Horvath, Rita; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence Albert (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-01)
      We aimed to provide a detailed phenotypic description of status epilepticus (SE) in a large cohort of patients with POLG disease and identify prognostic biomarkers to improve the management of this life-threatening condition. In a multinational, retrospective study with data on patients with POLG disease from seven European countries, we identified those who had SE. The age of SE onset, accompanying ...

    • Plugging of pipes by cohesive particles. Computed tomography investigation and theoretical analysis 

      Balakin, Boris; Chang, Yu-Fen; Øynes, Mona; Struchalin, Pavel (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-09)
      Flow regimes leading to clogging of pipes exist for most multiphase flows with cohesive particles. Although plugging is critical in many industrial and medical applications, there are few records describing the details of the process. To address the problem, we conduct a computed tomography (CT) study of plugging in a cohesive ice slurry. We run experiments for ice concentration of 15%, Re∼3500, ...

    • Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10 

      Soløy-Nilsen, Hedda; Nygaard-Odeh, Kristin; Kristiansen, Magnhild Gangsøy; Kvig, Erling Inge; Brekke, Ole Lars; Mollnes, Tom Eirik; Berk, Michael; Reitan, Solveig Klæbo; Øiesvold, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)
      Objective: Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform pathobiology and treatment opportunities. The aim of this study is to explore if there are associations between cytokines and psychiatric symptom clusters. Comparison between patients ...

    • Botulinum Toxin A and B for Palmoplantar Hyperhidrosis 

      Eilertsen, Trond; Kvammen, Bjørn Øivind; Grimstad, Øystein (Journal article; Tidsskriftartikkel, 2024-03-01)
      Introduction - Hyperhidrosis is characterized by unpredictable, uncontrollable and excessive sweating. It occurs at rest and is not related to temperature. Hyperhidrosis is a common disorder that has a negative impact on quality of life (QoL). The aim of this quality assurance study was to investigate how treatment of palmoplantar hyperhidrosis with botulinum toxin A (BTX-A) and botulinum toxin B ...

    • Comparative Effectiveness and Persistence of SB4 and Reference Etanercept in Patients With Psoriatic Arthritis in Norway 

      Łosińska, Katarzyna Weronika; Pripp, Are Hugo; Bakland, Gunnstein; Fevang, Bjørg Tilde Svanes; Brekke, Lene Kristin; Wierød, Ada; Korkosz, Mariusz; Haugeberg, Glenn (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)
      Objective - We aim to compare drug effectiveness and persistence between the reference etanercept (ETN) and ETN biosimilar SB4 in patients with psoriatic arthritis (PsA) naive to ETN and to investigate drug effectiveness and persistence in those undergoing a mandatory nonmedical switch from ETN to SB4.<p> <p>Methods - We used a retrospective comparative database study including 1,138 patients ...