Institutt for klinisk medisin: Recent submissions
Now showing items 341-360 of 1934
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ATPase activity of DFCP1 controls selective autophagy
(Journal article; Tidsskriftartikkel, 2023-07-08)Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms ... -
Forearm fractures–are we counting them all? An attempt to identify and include the missing fractures treated in primary care
(Journal article; Tidsskriftartikkel, 2023-07-07)Objective: Norway has a high incidence of forearm fractures, however, the incidence rates based on secondary care registers can be underestimated, as some fractures are treated exclusively in primary care. We estimated the proportion of forearm fracture diagnoses registered exclusively in primary care and assessed the agreement between diagnosis for forearm fractures in primary and secondary care. ... -
Minor changes in the incidence of primary and secondary involuntary childlessness across birth cohorts 1916 to 1975, but major differences in treatment success
(Journal article; Tidsskriftartikkel, 2023-07-12)There have been tremendous advances in assisted reproductive technologies (ARTs) over the past 50 years. The present study assessed infertility outcomes among women of reproductive age during this period. The seventh survey of the Tromsø Study (Tromsø7, 2015–16) recruited Tromsø residents aged 40–98 years. The questionnaire collected information on sociodemographics and infertility, as well as data ... -
Inhibition of a new AXL isoform (AXL3) induces apoptosis of mantle cell lymphoma cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma having a poor overall survival that is in need for the development of new therapeutics. In this study, we report the identification and expression of a new isoform splice variant of the tyrosine kinase receptor AXL in MCL cells. This new AXL isoform, called AXL3, lacks the ligand-binding domain of the commonly described AXL ... -
Relationship between Ketones, Ghrelin, and, Appetite on Isocaloric Diets with Varying Carbohydrate Quality and Amount: Results from a Randomized Controlled Trial in People with Obesity (CARBFUNC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-29)Background - Low-carbohydrate high-fat (LCHF) diets may suppress the increase in appetite otherwise seen after diet-induced fat loss. However, studies of diets without severe energy restriction are lacking, and the effects of carbohydrate quality relative to quantity have not been directly compared.<p> <p>Objectives - To evaluated short- (3 mo) and long-term (12 mo) changes in fasting plasma ... -
Behandling av håndleddsbrudd 2009-14
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-16)Bakgrunn<p> <p>Målet med studien var å utføre en systematisk analyse basert på data fra Norsk pasientregister og beskrive forekomst og behandling av håndleddsbrudd blant voksne på nasjonalt nivå og i opptaksområdene til de ulike helseforetakene.<p> <p>Materiale og metode <p>Det ble gjort søk i Norsk pasientregister eer alle pasienter ≥ 18 år med diagnosekodene for håndleddsbrudd i perioden 2009–14. ... -
Mutasjonstesting ved ikke-småcellet lungekreft
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-04-30)Bakgrunn. Epidermal vekstfaktorreseptor (EGFR) tyrosinkinasehemmere (EGFR-TKI) er en relativt ny klasse legemidler til behandling av ikke-småcellet lungekreft. Den nasjonale faggruppen for lungekreft, Norsk Lunge Cancer Gruppe, anbefaler at pasienter med ikke-småcellet lungekreft testes for mutasjoner i EGFRgenet. Vi rapporterer her erfaringene som er gjort etter at slik testing ble innført i ... -
Early death after palliative radiation treatment: 30-, 35- and 40-day mortality data and statistically robust predictors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-03)Background This study analyzed mortality after radiotherapy for bone metastases (287 courses). Endpoints such as treatment in the last month of life and death within 30, 35 and 40 days from start of radiotherapy were evaluated.<p> <p>Methods Different baseline parameters including but not limited to blood test results and patterns of metastases were assessed for association with early death. After ... -
Palliative appropriateness criteria: external validation of a new method to evaluate the suitability of palliative radiotherapy fractionation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)Background Recently, the palliative appropriateness criteria (PAC) score, a novel metric to aid clinical decision-making between different palliative radiotherapy fractionation regimens, has been developed. It includes baseline parameters including but not limited to performance status. The researchers behind the PAC score analyzed the percent of remaining life (PRL) on treatment. The latter was ... -
Rapport fra 25. juni-utvalget: Evaluering av PST og politiet
(Research report; Forskningsrapport, 2023) -
The Practically Wise Medical Teacher: Medical Education at the University of Tromsø – A Norwegian Case
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-19)This article addresses the issue of teaching quality in medical education and investigates what characterizes a professionally competent or practically wise medical teacher through the use of longitudinal data from interviews with 40 medical students. In discussing the findings, Aristotle’s concepts of episteme, techne and phronesis, and theoretical perspectives on professionalism and quality in ... -
Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-02)Objective To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS).<p> <p>Design Cohort study using a nationwide, population-based registry. <p>Setting 21 neonatal units in Norway. <p>Participants All very preterm infants born 1 January 2009–31 December 2018 and admitted to a neonatal ... -
Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)Background: Venous thromboembolism (VTE) is a frequent disease with a high risk of recurrence. It has been suggested that the D-dimer level at the time of VTE diagnosis can be used to identify patients at a low risk of recurrence. Objectives: We aimed to investigate the impact of D-dimer levels measured at the time of VTE diagnosis on the risk of recurrence in a large cohort of patients with a ... -
The association between infant salivary cortisol and parental presence in the neonatal intensive care unit during and after COVID-19 visitation restrictions: A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-07)Objectives: Parent-infant interaction in the neonatal intensive care unit (NICU) promotes health and reduces infant stress. During the COVID-19 pandemic, however, NICUs restricted parent-infant interaction to reduce viral transmission. This study examined the potential relationship between pandemic visitation restrictions, parental presence and infant stress as measured by salivary cortisol. Methods: ... -
Cause-specific excess mortality after hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)Background Information on cause of death may help appraise the degree to which the high excess mortality after hip fracture refects pre-existing comorbidities or the injury itself. We aimed to describe causes of death and causespecifc excess mortality through the frst year after hip fracture.<p> <p>Methods For studying the distribution of causes of death by time after hip fracture, we calculated ... -
Sutur av degenerative rotatorcuff-rupturer: en fullstendig metodevurdering
(Research report; Forskningsrapport, 2023)Vi har utarbeidet en fullstendig metodevurdering av kirurgi med sutur sammenlignet med ikke-kirurgisk behandling ved degenerativ fulltykkelse rotatorcuff-ruptur. Vi inkluderte fem randomiserte og 18 ikke-randomiserte studier. Vi sammenstilte studiene i metaanalyser og vurderte tilliten til effektestimatene med GRADE-tilnærmingen. <p> <uli> <li>For pasienter med ruptur i én sene gir kirurgi liten ... -
Spillbasert læring: motivasjon for å ta i bruk ny teknologi
(Conference object; Konferansebidrag, 2023-03)Spillbasert læring bruker prinsipper fra spill for å engasjere og motivere studenter i sin læring. I kombinasjon med innsikter om effektive læringsstrategier kan spillbaserte læringsressurser sikre både motivasjon til å lære og en effektiv læringsprosess. En forutsetning for å lykkes med introduksjon av ny teknologi generelt og spillbaserte læringsressurser spesifikt er at teknologien aksepteres av ... -
Wake-up stroke and unknown-onset stroke; occurrence and characteristics from the nationwide Norwegian Stroke Register
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06)Introduction: Population-based knowledge of the characteristics of wake-up stroke and unknown-onset stroke is limited. We compared occurrence and characteristics of ischaemic and haemorrhagic wake-up stroke, unknown-onset stroke and known-onset stroke in a nationwide register-based study. <p> <p>Patients and methods: We included patients registered in the Norwegian Stroke Register from 2012 through ... -
Characterization of vasskveite (water halibut) syndrome for automated detection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-23)In recent years, cases of vasskveite (water halibut) syndrome in halibut have been increasing. At the moment, there exists no way to screen for the syndrome immediately after capture, which is problematic for both exporters and purchasers. In this article, we compared good quality halibut and halibut exhibiting the syndrome using a variety of techniques. Hyperspectral imaging was used to quantify ... -
Rapport omsvangerskapsavbrot 2022
(Research report; Forskningsrapport, 2023)Det føreligg statistikk over talet på begjæringar, tal på innvilga begjæringar i nemnd og tal på utførte svangerskapsavbrot i Noreg sidan 1979. Statistisk sentralbyrå hadde ansvaret for abortstatistikken frå 1979 til og med 2005. Frå og med 2006 har Folkehelseinstituttet vore ansvarleg for statistikken, og frå og med 2008 ansvarleg for databehandlinga av Register over svangerskapsavbrudd (Abo ...