Institutt for klinisk medisin: Recent submissions

Now showing items 81-100 of 1920

    • The epidemiology of major depression among adults in Norway: an observational study on the concurrence between population surveys and registry data – a NCDNOR project 

      Bramness, Jørgen Gustav; Hjellvik, Vidar; Høye, Anne; Tesli, Martin Steen; Haram, Marit; Nystad, Wenche; Krokstad, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-17)
      Background Mental health problems, and major depression in particular, are important public health issues. Following trends in the prevalence of major depression is difficult because of the costs and complications of diagnostic interviews and general population self-report health surveys. Scandinavian countries, however, have several central, population-based health registries. We aimed to ...

    • Epidemiology and natural history of POLG disease in Norway: a nationwide cohort study 

      Kristensen, Erle; Mathisen, Linda; Berland, Siren; Klingenberg, Claus Andreas; Brodtkorb, Eylert; Rasmussen, Magnhild; Tangeraas, Trine; Bliksrud, Yngve Thomas; Rahman, Shamima; Bindoff, Laurence Albert; Hikmat, Omar (Journal article; Tidsskriftartikkel, 2024-06-07)
      <p><i>Objective</i> To investigate the prevalence and natural history of POLG disease in the Norwegian population. <p><i>Methods</i> A national, population-based, retrospective study using demographic, clinical, and genetic data of patients with genetically confirmed POLG disease. The patients were diagnosed between 2002 and 2022, and were included into the Norwegian POLG Patient Registry. Patients ...

    • Primary Retroperitoneal Lymph Node Dissection as Treatment for Low-volume Metastatic Seminoma in a Population-based Cohort: The Swedish Norwegian Testicular Cancer Group Experience 

      Thor, Anna; Negaard, Helene Francisca Stigter; Grenabo Bergdahl, Anna; Almås, Bjarte; Larsen, Signe Melsen; Lundgren, Per-Olof; Gerdtsson, Axel; Halvorsen, Dag; Johannsdottir, Berglind; Jansson, Anna K.; Hellström, Martin; Wahlqvist, Rolf; Langberg, Carl W.; Hedlund, Annika; Akre, Olof; Glimelius, Ingrid; Ståhl, Olof; Haugnes, Hege Sagstuen; Cohn-Cedermark, Gabriella; Kjellman, Anders; Tandstad, Torgrim (Journal article; Tidsskriftartikkel, 2024-06-11)
      <p><i>Background and objective</i> There is an unmet need to avoid long-term morbidity associated with standard cytotoxic treatment for low-volume metastatic seminoma. Our aim was to assess the oncological efficacy and surgical safety of retroperitoneal lymph node dissection (RPLND) as treatment in a population-based cohort of metastatic seminoma patients with limited retroperitoneal lymphadenopat ...

    • Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series 

      Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann; Balstad, Trude Rakel; Bye, Asta; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Maddocks, Matthew; McDonald, James; Ottestad, Inger; Phillips, Iain; Sayers, Judith; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Solheim, Tora S; Laird, Barry J; Skipworth, Richard J.E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-13)
      Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selected measures or their potential sensitivity to detect changes resulting from the interventions being examined. The aim of this systematic review is to assess the ...

    • Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations 

      Lavinio, Andrea; Coles, Jonathan P.; Robba, Chiara; Aries, Marcel; Bouzat, Pierre; Chean, Dara; K Frisvold, Shirin; Galarza, Laura; Helbok, Raimund; Hermanides, Jeroen; van der Jagt, Mathieu; Menon, David K.; Meyfroidt, Geert; Payen, Jean-Francois; Poole, Daniele; Rasulo, Frank; Rhodes, Jonathan; Sidlow, Emily; Steiner, Luzius A.; Taccone, Fabio Silvio; Takala, Riikka (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-20)
      Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management.<p> <p>Methods A group of 18 international neuro-intensive care experts in the acute ...

    • Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series 

      Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Dajani, Olav; Fallon, Marie; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; McDonald, James; McGovern, Josh; Roeland, Eric J.; Sayers, Judith; Skipworth, Richard J.E.; Ottestad, Inger; Philips, Iain; Simpson, Melanie Rae; Solheim, Tora S; Vagnildhaug, Ola Magne; McMillan, Donald; Laird, Barry J; Dolan, Ross D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-23)
      Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers features frequently. The aim of this systematic review was to assess the frequency and diversity of biomarker endpoints in cancer cachexia trials. A comprehensive ...

    • Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer—a prospective national multicentre study (EMIT-1) 

      Ohnstad, Hege Oma; Blix, Egil Støre; Akslen, Lars Andreas; Gilje, Bjørnar; Raj, Sunil Xavier; Skjerven, Helle; Borgen, Elin; Janssen, Emiel; Mortensen, Elin Synnøve; Brekke, Marianne B.; Falk, Ragnhild Sørum; Schlichting, Ellen; Boge, Beate; Songe-Møller, Silje; Olsson, Pernilla Marie A.; Heie, Anette; Mannsåker, Bård; Vestlid, Magdalena Aas; Kursetgjerde, Torgunn; Gravdehaug, Berit; Suhrke, Pål; Sánchez, E.; Bublevic, J.; Røe, Oluf Dimitri; Geitvik, Gry; Halset, Eline Holli; Rypdal, Maria Christine; Langerød, Anita; Lømo, Jon; Garred, Øystein; Porojnicu, Alina Carmen; Engebraaten, O.; Geisler, Jürgen; Lyngra, Marianne; Hansen, M. H.; Søiland, Håvard; Nakken, T.; Asphaug, Lars; Kristensen, Vessela N.; Sørlie, Therese; Nygård, Jan Franz; Kiserud, Cecilie E.; Reinertsen, Kristin Valborg; Russnes, Hege Elisabeth Giercksky; Naume, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-04)
      Background: EMIT-1 is a national, observational, single-arm trial designed to assess the value of the Prosigna, Prediction Analysis of Microarray using the 50 gene classifier (PAM50)/Risk of Recurrence (ROR), test as a routine diagnostic tool, examining its impact on adjuvant treatment decisions, clinical outcomes, side-effects and cost-effectiveness. Here we present the impact on treatment ...

    • Survival after docetaxel for metastatic castration-resistant prostate cancer in a rural health care setting 

      Nieder, Carsten; Stanisavljevic, Luka; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-15)
      Introduction: The aim of this study was to evaluate overall survival of men who received systemic therapy with docetaxel for metastatic castrationresistant prostate cancer (MCRPC) in rural Nordland County, Norway. Prognostic factors related to treatment and other variables were evaluated.<p> <p>Material and methods: Overall, 132 pa tients were included in this retrospective study covering the ...

    • Dietitians' experiences of nutrition assessment via TeleNutrition: “Video-calls are better than phone-calls, but it's probably difficult for patients to show their ankles on the screen” 

      Einarsson, Sandra; Thoresen, Lene; Tobberup, Randi; Paur, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-27)
      Background & Aims: Nutrition assessment is integral to dietetic practice. TeleNutrition enabled dietitians to continue nutrition care provision during the COVID-19 pandemic but created challenges with undertaking nutrition assessment. The aim of the present study was to describe how dietitians in three Nordic countries perceived their nutrition assessment practice when physically distant from ...

    • DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies 

      Meng, Wei; Fenton, Christopher Graham; Johnsen, Kay-Martin; Taman, Hagar; Florholmen, Jon; Paulssen, Ruth Erika Hildegard Hracky (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-21)
      DNA methylation has been implied to play a role in the immune dysfunction associated with inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC). Changes of the DNA methylation and correlated gene expression in patient samples with inactive UC might reveal possible regulatory features important for further treatment options for UC. Targeted bisulfite sequencing ...

    • MRSA-halsbærerskap hos to helsearbeidere 

      Evenstad, Berit; Halvorsen, Dag Seeger; Myrbakk, Torni (Journal article; Tidsskriftartikkel, 2024-02-14)
      Helsearbeidere med påvist bærerskap av meticillinresistente Staphylococcus aureus (MRSA) opplever ofte negative konsekvenser, slik som arbeidsrestriksjoner, langvarige sykmeldinger, repeterte saneringsforsøk, stigmatisering og psykososialt stress. Vi omtaler to studenter som etter flere mislykkede saneringsforsøk fikk utført tonsillektomi for å kvitte seg med halsbærerskap.

    • A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy 

      Bekkelund, Svein Ivar; Abeler, Karin Louise; Lilleng, Hallvard; Løseth, Sissel (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-15)
      Creatine kinase (CK) has been associated with neuropathy, but the mechanisms are uncertain. We hypothesized that peripheral nerve function is impaired in subjects with persistent CK elevation (hyperCKemia) compared to age- and sex matched controls in a general population. The participants were recruited from the population based Tromsø study in Norway. Neuropathy impairment score (NIS), nerve ...

    • The fatty liver index and risk of incident venous thromboembolism: the Tromsø Study 

      Scheres, Luuk J.J.; Brækkan, Sigrid Kufaas; Verlaan, Judith P.L.; Cannegieter, Suzanne C.; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-20)
      Background: For the relationship between obesity and venous thromboembolism (VTE), nonalcoholic fatty liver disease (recently termed metabolic dysfunction– associated steatotic liver disease) is of interest given the hepatic role in hemostasis.<p> <p>Objectives: We aimed to assess the association between the fatty liver index (FLI), as a proxy for nonalcoholic fatty liver disease, and VTE risk ...

    • Proportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and women 

      Arnesen, Carl-Arne; Evensen, Line Holtet; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-08)
      Background: Data on the proportion of venous thromboembolism (VTE) risk attributed to prothrombotic genotypes in men and women are limited.<p> <p>Objectives: We aimed to estimate the population attributable fraction (PAF) of VTE for recognized, common prothrombotic genotypes in men and women using a populationbased case cohort. <p>Methods: Cases with incident VTE (n = 1493) and a randomly sampled ...

    • Loneliness in adolescence and prescription of psychotropic drugs in adulthood: 23-year longitudinal population-based and registry study 

      Rodriguez-Cano, Ruben; Lotre, Karianne; von Soest, Tilmann; Rognli, Eline B.; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-11)
      Aims We aim to determine whether (a) experiencing loneliness in adolescence and (b) changes in loneliness from adolescence to adulthood are prospectively associated with prescriptions for a variety of psychotropic drugs in adulthood.<p> <p>Method We used data from a Norwegian population-based sample with 2602 participants, collected across four waves between 1992 and 2006. Loneliness was assessed ...

    • Team-based learning (TBL) in clinical disciplines for undergraduate medical students—a scoping review 

      Sterpu, Irene; Herling, Lotta; Nordquist, Jonas; Rotgans, Jerome; Acharya, Ganesh Prasad (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-03)
      Background Team-based learning (TBL) is an evidence-based pedagogical method that has been used in undergraduate medical education since 2001. However, its use in clinical disciplines is rarely reported, and the impact of its implementation is not known. The aim of this study was to explore and map the published literature on the impact of implementing TBL in clinical disciplines in undergraduate ...

    • Disruption of sleep by one night of in-home polysomnographic recording: a longitudinal actigraphy study of patients with chronic musculoskeletal pain and pain-free controls 

      Abeler, Karin Louise; Bergvik, Svein Hugo; Friborg, Oddgeir (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-25)
      Background Patients with chronic pain frequently have comorbid sleep disturbances. Since improvement of sleep may alleviate both sleep problems and to some extent pain, sleep studies in this group becomes relevant. Polysomnography (PSG) is considered the gold standard for characterizing sleep; however, it is resource-demanding and may itself disrupt sleep due to the use of inconvenient equipment in ...

    • Long-term cardiac effects of modern treatment for Hodgkin’s lymphoma 

      Bjerring, Anders W.; Smeland, Knut Bjøro; Stokke, Thomas Muri; Haugaa, Kristina Ingrid Helena Hermann; Holte, Espen; Rösner, Assami; Kiserud, Cecilie E.; Edvardsen, Thor; Sarvari, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-04)
      Background Hodgkin’s lymphoma (HL) is a hematological malignancy that affects both children and young adults. Traditional treatment is associated with a life-time prevalence of cardiac disease exceeding 50%. In the late 1990s protocols were modified to reduce cancer therapy-related adverse cardiac effects. This study aimed to assess the long-term impact of advances in treatment protocols on the ...

    • Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series 

      Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Coats, Andrew J.S.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Grzyb, Alexandra; Kaasa, Stein; Koteng, Lisa Heide; May, Anne M.; McDonald, James; Ottestad, Inger; Philips, Iain; Roeland, Eric J.; Sayers, Judith; Simpson, Melanie Rae; Skipworth, Richard J.E.; Solheim, Tora S; Sousa, Mariana S.; Vagnildhaug, Ola Magne; Laird, Barry J.A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-29)
      The use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. This review describes the frequency, variety, and reporting of QOL endpoints used in cancer cachexia clinical trials. Electronic literature searches were performed in Medline, ...

    • A human stomach cell type transcriptome atlas 

      Struck, Eike Christopher; Odeberg, Jacob Olof; Öling, S.; Noreen-Thorsen, M.; Zwahlen, M.; von Feilitzen, K.; Pontén, F.; Lindskog, C.; Butler, Lynn; Uhlén, M.; Dusart, P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-14)
      Background The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointestinal tract, provides an acidic environment that contributes to microbial defence and facilitates the activity of secreted digestive enzymes to process food and nutrients into ...