Institutt for klinisk medisin: Nye registreringer
Viser treff 201-220 av 1804
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Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-19): The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). Most functional studies of missense variants in BRCA1 focus on variants located within the Really Interesting New Gene (RING), coiled-coil and BRCA1 C-terminal (BRCT) ... -
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-07)Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement ... -
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-02)Background<p> <p>Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population. <p>Methods <p>Associations between CK and the outcome variable ... -
Personalized radiotherapy of brain metastases: survival prediction by means of dichotomized or differentiated blood test results?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-11)Background and objectives: The validated LabBM score (laboratory parameters in patients with brain metastases) represents a widely applicable survival prediction model, which incorporates 5 blood test results (serum lactate dehydrogenase (LDH), C-reactive protein (CRP), albumin, platelets and hemoglobin). All tests are classified as normal or abnormal, without accounting for the wide range of ... -
Impact of microvessel patterns and immune status in NSCLC: a non-angiogenic vasculature is an independent negative prognostic factor in lung adenocarcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)Introduction: Non-small cell lung carcinomas (NSCLC) exhibit different microvessel patterns (MVPs). Basal (BA), diffuse (DA) and papillary (PA) patterns show signs of angiogenesis (new blood vessels), while an alveolar pattern indicates that tumors are co-opting existing normal vessels (non-angiogenic alveolar, NAA). NAA tumor growth is known to exist in NSCLC, but little is known about its prognostic ... -
Targeting NETs using dual-active DNase1 variants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-23)Background: Neutrophil Extracellular Traps (NETs) are key mediators of immunothrombotic mechanisms and defective clearance of NETs from the circulation underlies an array of thrombotic, inflammatory, infectious, and autoimmune diseases. Efficient NET degradation depends on the combined activity of two distinct DNases, DNase1 and DNase1-like 3 (DNase1L3) that preferentially digest double-stranded DNA ... -
Clinical Diagnostics of Bacterial Infections and Their Resistance to Antibiotics—Current State and Whole Genome Sequencing Implementation Perspectives
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-19)Antimicrobial resistance (AMR), defined as the ability of microorganisms to withstand antimicrobial treatment, is responsible for millions of deaths annually. The rapid spread of AMR across continents warrants systematic changes in healthcare routines and protocols. One of the fundamental issues with AMR spread is the lack of rapid diagnostic tools for pathogen identification and AMR detection. ... -
Preoperative Inflammatory Markers in Liver Resection for Colorectal Liver Metastases: A National Registry-Based Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-04)Background Preoperative inflammatory markers were shown to be associated with prognosis following surgery for hepato-pancreato-biliary cancer. Yet little evidence exists about their role in patients with colorectal liver metastases (CRLM). This study aimed to examine the association between selected preoperative inflammatory markers and outcomes of liver resection for CRLM.<p> <p>Methods Data ... -
Plasma levels of P-selectin and future risk of incident venous thromboembolism
(Journal article; Tidsskriftartikkel, 2023-05-12)Background - P-selectin levels are elevated following acute deep vein thrombosis and reported to predict recurrent venous thromboembolism (VTE) and cancer-associated VTE. Yet, it is unknown whether plasma P-selectin levels are associated with incident VTE.<p> <p>Objectives - We aimed to investigate the association between plasma P-selectin levels and risk of future incident VTE.<p> <p>Methods ... -
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)Mitochondria are susceptible to damage resulting from their activity as energy providers. Damaged mitochondria can cause harm to the cell and thus mitochondria are subjected to elaborate quality-control mechanisms including elimination via lysosomal degradation in a process termed mitophagy. Basal mitophagy is a house-keeping mechanism fine-tuning the number of mitochondria according to the metabolic ... -
ATPase activity of DFCP1 controls selective autophagy
(Journal article; Tidsskriftartikkel, 2023-07-08)Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms ... -
Forearm fractures–are we counting them all? An attempt to identify and include the missing fractures treated in primary care
(Journal article; Tidsskriftartikkel, 2023-07-07)Objective: Norway has a high incidence of forearm fractures, however, the incidence rates based on secondary care registers can be underestimated, as some fractures are treated exclusively in primary care. We estimated the proportion of forearm fracture diagnoses registered exclusively in primary care and assessed the agreement between diagnosis for forearm fractures in primary and secondary care. ... -
Minor changes in the incidence of primary and secondary involuntary childlessness across birth cohorts 1916 to 1975, but major differences in treatment success
(Journal article; Tidsskriftartikkel, 2023-07-12)There have been tremendous advances in assisted reproductive technologies (ARTs) over the past 50 years. The present study assessed infertility outcomes among women of reproductive age during this period. The seventh survey of the Tromsø Study (Tromsø7, 2015–16) recruited Tromsø residents aged 40–98 years. The questionnaire collected information on sociodemographics and infertility, as well as data ... -
Inhibition of a new AXL isoform (AXL3) induces apoptosis of mantle cell lymphoma cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma having a poor overall survival that is in need for the development of new therapeutics. In this study, we report the identification and expression of a new isoform splice variant of the tyrosine kinase receptor AXL in MCL cells. This new AXL isoform, called AXL3, lacks the ligand-binding domain of the commonly described AXL ... -
Relationship between Ketones, Ghrelin, and, Appetite on Isocaloric Diets with Varying Carbohydrate Quality and Amount: Results from a Randomized Controlled Trial in People with Obesity (CARBFUNC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-29)Background - Low-carbohydrate high-fat (LCHF) diets may suppress the increase in appetite otherwise seen after diet-induced fat loss. However, studies of diets without severe energy restriction are lacking, and the effects of carbohydrate quality relative to quantity have not been directly compared.<p> <p>Objectives - To evaluated short- (3 mo) and long-term (12 mo) changes in fasting plasma ... -
Behandling av håndleddsbrudd 2009-14
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-16)Bakgrunn<p> <p>Målet med studien var å utføre en systematisk analyse basert på data fra Norsk pasientregister og beskrive forekomst og behandling av håndleddsbrudd blant voksne på nasjonalt nivå og i opptaksområdene til de ulike helseforetakene.<p> <p>Materiale og metode <p>Det ble gjort søk i Norsk pasientregister eer alle pasienter ≥ 18 år med diagnosekodene for håndleddsbrudd i perioden 2009–14. ... -
Mutasjonstesting ved ikke-småcellet lungekreft
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-04-30)Bakgrunn. Epidermal vekstfaktorreseptor (EGFR) tyrosinkinasehemmere (EGFR-TKI) er en relativt ny klasse legemidler til behandling av ikke-småcellet lungekreft. Den nasjonale faggruppen for lungekreft, Norsk Lunge Cancer Gruppe, anbefaler at pasienter med ikke-småcellet lungekreft testes for mutasjoner i EGFRgenet. Vi rapporterer her erfaringene som er gjort etter at slik testing ble innført i ... -
Early death after palliative radiation treatment: 30-, 35- and 40-day mortality data and statistically robust predictors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-03)Background This study analyzed mortality after radiotherapy for bone metastases (287 courses). Endpoints such as treatment in the last month of life and death within 30, 35 and 40 days from start of radiotherapy were evaluated.<p> <p>Methods Different baseline parameters including but not limited to blood test results and patterns of metastases were assessed for association with early death. After ... -
Palliative appropriateness criteria: external validation of a new method to evaluate the suitability of palliative radiotherapy fractionation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)Background Recently, the palliative appropriateness criteria (PAC) score, a novel metric to aid clinical decision-making between different palliative radiotherapy fractionation regimens, has been developed. It includes baseline parameters including but not limited to performance status. The researchers behind the PAC score analyzed the percent of remaining life (PRL) on treatment. The latter was ... -
Rapport fra 25. juni-utvalget: Evaluering av PST og politiet
(Research report; Forskningsrapport, 2023)