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Brain Metastases: Is There Still a Role for Whole-Brain Radiation Therapy?

Permanent lenke
https://hdl.handle.net/10037/32691
DOI
https://doi.org/10.1016/j.semradonc.2023.01.005
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article.pdf (397.6Kb)
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Dato
2023-03-27
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Nieder, Carsten; Andratschke, Nicolaus H.; Grosu, Anca L.
Sammendrag
Whole-brain radiation therapy (WBRT) has commonly been prescribed to palliate symptoms from brain metastases, to reduce the risk of local relapse after surgical resection, and to improve distant brain control after resection or radiosurgery. While targeting micrometastases throughout the brain can be considered advantageous, the simultaneous exposure of healthy brain tissue might cause adverse events. Attempts to mitigate the risk of neurocognitive decline after WBRT include the selective avoidance of the hippocampi, among others. Besides selective dose reduction, dose escalation to boost volumes, for example, simultaneous integrated boost, aiming at increased tumor control probability is technically feasible. While up-front radiotherapy for newly diagnosed brain metastases often employs radiosurgery or other techniques targeting visible lesions only, sequential (delayed) salvage treatment with WBRT might still become necessary. In addition, the presence of leptomeningeal tumors or very widespread parenchymatous brain metastases might prompt clinicians to prescribe early WBRT.
Forlag
Elsevier
Sitering
Nieder, Andratschke, Grosu. Brain Metastases: Is There Still a Role for Whole-Brain Radiation Therapy?. Seminars in Radiation Oncology. 2023;33(2):129-138
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2023 The Author(s)

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