Institutt for klinisk medisin: Nye registreringer
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I don’t want to think about it: A qualitative study of children’s and parents’ experiences with regular needle injections at home
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)<i>Background</i> - Overall outcomes of pediatric rheumatic diseases (RD) have improved due to treatment with biologic agents and methotrexate. For many children, this treatment often entails regular needle injections. Pain and fear of needle injections are common in childhood, but how children and parents handle long-term needle injections at home has not been fully explored. This study aimed to ... -
The value of dynamic infrared thermography in pedicled thoracodorsal artery perforator flap surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)<p><i>Background:</i> Dynamic infrared thermography (DIRT) is a noninvasive imaging technique that can provide indirect and real-time information on skin perfusion by measuring skin temperature. Although used in flap surgery, there are no reports on its value in procedures using a pedicled thoracodorsal artery perforator (TDAP) flap. The aim of this study was to assess the usefulness of DIRT in ... -
Factors Engaging Users of Diabetes Social Media Channels on Facebook, Twitter, and Instagram: Observational Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-29)<p><i>Background:</i> Diabetes patient associations and diabetes-specific patient groups around the world are present on social media. Although active participation and engagement in these diabetes social media groups has been mostly linked to positive effects, very little is known about the content that is shared on these channels or the post features that engage their users the most. <p><i>Objective:</i> ... -
Epipericardial Fat Necrosis: A Case Report and a Review of the Literature
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-16)Epipericardial fat necrosis (EFN), also known as pericardial or mediastinal fat necrosis, has until lately been considered an unusual cause of acute chest pain. Due to increased use of computed tomography (CT) and other imaging techniques, EFN is now believed to be an under-diagnosed cause of acute chest pain. We here present a patient with a short history of acute, left-sided pleuritic chest pain ... -
Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)<i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ... -
Thromboelastometry for Assessing Risks of Free Flap Thrombosis in Patients Undergoing Microvascular Surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-23)<p>Introduction</i>: Coagulation assessment is often missing in microvascular surgery. We aimed at evaluating the predictive value of thromboelastometry for free flap thrombosis in microvascular surgery patients.<p> <p> <i>Materials and Methods</i>: We enrolled 103 adult patients with traumatic injuries scheduled for microvascular free flap surgery into a prospective observational study. Thirty-six ... -
Hearing in schoolchildren after neonatal exposure to a high-dose gentamicin regimen
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)<p>OBJECTIVE: To assess the association between gentamicin exposure in the neonatal period and hearing in school age. <p>METHODS: This study included children exposed to a high-dose (6 mg/kg) gentamicin regimen as neonates (2004–2012), invited for follow-up at school age, and a healthy age-matched control group. We assessed hearing with pure tone audiometry including the extended high-frequency ... -
Optimized cutoff maternal age for adverse obstetrical outcomes: A multicenter retrospective cohort study in Urban China during 2011 to 2012
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-05)<p><i>Background: </i>China's two-child policy has led to a trend of aging in pregnancy which was associated with adverse outcomes. This study aimed to identify the clinically cutoff maternal age for adverse obstetric outcomes in China. <p><i>Methods: </i>This secondary analysis of a multicenter retrospective cohort study included data of childbearing women from 39 hospitals collected in urban China ... -
Expression of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-29)The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely the last decades. In a previous clinical study of endometrial hyperplasia, we observed that the antiproliferative progestin effect persisted after ... -
Lifestyle among long-term survivors of cancers in young adulthood
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-01)<i>Purpose</i> - To investigate lifestyle in a population-based sample of long-term (≥ 5 years since diagnosis) young adult cancer survivors (YACSs), and explore factors associated with not meeting the lifestyle guidelines for physical activity (PA), body mass index (BMI), and smoking. <p> <p><i>Methods</i> - YACSs (<i>n</i> = 3558) diagnosed with breast cancer (BC), colorectal cancer (CRC), ... -
DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-28)Despite having common overlapping immunophenotypic and morphological features, T-cell lymphoblastic leukemia (T-ALL) and lymphoma (T-LBL) have distinct clinical manifestations, which may represent separate diseases. We investigated and compared the epigenetic and genetic landscape of adult and pediatric T-ALL (<i>n</i> = 77) and T-LBL (<i>n</i> = 15) patient samples by high-resolution genome-wide ... -
Assessing communication during remote follow-up of users with pacemakers in Norway: The Nordland study, a randomized trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-21)As effective communication is a key ingredient for the provision of quality healthcare services, this study aimed to explore the communication experiences in the remote monitoring of older adults with a pacemaker. The study was based on a non-masked randomized observational design. The Healthcare Communication Questionnaire and in-depth interviews were conducted for data collection. A total of 49 ... -
Comparison between two pharmacologic strategies to alleviate rewarming shock: vasodilation vs. inodilation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)Rewarming from hypothermia is often challenged by coexisting cardiac dysfunction, depressed organ blood flow (OBF), and increased systemic vascular resistance. Previous research shows cardiovascular inotropic support and vasodilation during rewarming to elevate cardiac output (CO). The present study aims to compare the effects of inodilatation by levosimendan (LS) and vasodilation by nitroprusside ... -
Effect of Once-Weekly Azithromycin vs Placebo in Children With HIV-Associated Chronic Lung Disease: The BREATHE Randomized Clinical Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-17)<i>Importance</i> - HIV-associated chronic lung disease (HCLD) in children is associated with small airways disease, is common despite antiretroviral therapy (ART), and is associated with substantial morbidity. Azithromycin has antibiotic and immunomodulatory activity and may be effective in treating HCLD through reducing respiratory tract infections and inflammation.<p> <p><i>Objective</i> - ... -
Management of patients with acute ST-segment elevation myocardial infarction in Russian hospitals adheres to international guidelines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)<i>Objective</i> - Russia has one of the highest cardiovascular mortality rates. Modernisation of the Russian health system has been accompanied by a substantial increase in uptake of percutaneous coronary intervention (PCI), which substantially reduces the risk of mortality in patients with acute ST-elevation myocardial infarction (STEMI). This paper aims to describe contemporary Hospital treatment ... -
Platelet count and risk of major bleeding in venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)<p>The relationship between platelet count and risk of major bleeding in patients with venous thromboembolism (VTE) during anticoagulation remains unclear. We therefore investigated the association between platelet count, measured at VTE diagnosis and before the thrombotic event, and risk of major bleeding. Participants comprised 744 patients with incident VTE derived from the Tromsø Study. Major ... -
Infection prevention guidelines and considerations for paediatric risk groups when reopening primary schools during COVID-19 pandemic, Norway, April 2020
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-04)In response to the coronavirus disease (COVID-19) pandemic, most countries implemented school closures. In Norway, schools closed on 13 March 2020. The evidence of effect on disease transmission was limited, while negative consequences were evident. Before reopening, risk-assessment for paediatric risk groups was performed, concluding that most children can attend school with few conditions requiring ... -
Group-based multimodal physical therapy in women with chronic pelvic pain: A randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-09)<p><i>Introduction - </i>Chronic pelvic pain in women is a complex condition, and physical therapy is recommended as part of a broader treatment approach. The objective of this study was to compare structured group‐based multimodal physical therapy in a hospital setting (intervention group) with primary‐care physical therapy (comparator group) for women with chronic pelvic pain. <p><i>Material and ... -
Vitamin D supplementation for prevention of type 2 diabetes mellitus: To D or Not to D?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-26)<i>Context</i> - Over the last decade, vitamin D has emerged as a risk determinant for type 2 diabetes and vitamin D supplementation has been hypothesized as a potential intervention to lower diabetes risk. Recently, several trials have reported on the effect of vitamin D supplementation on diabetes prevention in people with prediabetes.<p> <p><i>Evidence Acquisition</i> - A comprehensive literature ... -
Digitally quantified CD8+ cells: the best candidate marker for an immune cell score in non-small cell lung cancer?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on choosing and incorporating subsets of tissue-infiltrating lymphocyte (TIL), detected by specific immunohistochemistry and automatically quantified by ...