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norskInstitutt for klinisk medisin: Nye registreringer
Viser treff 481-500 av 1930
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A nationwide study of patients operated for cervical degenerative disorders in public and private hospitals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-27)During the last decades, there has been an increase in the rate of surgery for degenerative disorders of the cervical spine and in the use of supplementary private health insurance. Still, there is limited knowledge about the diferences in characteristics of patients operated in public and private hospitals. Therefore, we aimed at comparing sociodemographic-, clinical- and patient management data ... -
Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)Epithelial alarmins are gaining interest as therapeutic targets for chronic infammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator of the infammatory cascade. However, it is not clear what signals drive the expression of IL-33 in the colonic mucosa, nor is the exact role of IL-33 elucidated. We ... -
Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima-Media Thickness: An Individual Participant Data Meta-Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)BACKGROUND: The major risk factors for atherosclerotic cardiovascular disease differ by race or ethnicity but have largely been defined using populations of European ancestry. Despite the rising prevalence of cardiovascular disease in Africa there are few related data from African populations. Therefore, we compared the association of established cardiovascular risk factors with carotid-intima ... -
Radiolegen
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-23)Han fikk avslag fra Teaterhøgskolen begge gangene han søkte. I dag bruker fastlege Morten Munkvik sine formidlingsevner til å lage bøker, tegneserier, sanger og radio om allmennmedisin til tusenvis av lyttere hver uke. -
Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-28)Identification of individuals with ischemic stroke at particularly high risk of venous thromboembolism (VTE) is crucial for targeted thromboprophylaxis. To guide clinical decision-making and development of risk prediction models, increased knowledge on risk factors and biomarkers is needed. Therefore, we set out to identify risk factors and predictors for VTE in people with ischemic stroke by ... -
Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: A feasibility study based on two VTE cohorts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-28)<b><p>Background</b> Venous thromboembolism (VTE) diagnosis would greatly benefit from the identification of novel biomarkers to complement D-dimer, a marker limited by low specificity. Neutrophil extracellular traps (NETs) have been shown to promote thrombosis and could hypothetically be used for diagnosis of acute VTE. <b><p>Objectives</b> To assess the levels of specific markers of ... -
Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-08)Background: Lower-leg injury and knee arthroscopy are both associated with venous thromboembolism (VTE). The mechanism of VTE in both situations is unknown, including the role of procoagulant microparticles. This may provide useful information for individualizing thromboprophylactic treatment in both patient groups.<p> <p>Objective: We aimed to study the effect of (1) lower-leg trauma and (2) ... -
ICU nurses´ lived experience of caring for adult patients with a tracheostomy in ICU: a phenomenological-hermeneutic study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-04)<b><p>Background</b> The care of adult patients with a tracheostomy in intensive care unit is complex, challenging and requires skilled intensive care unit nurses. ICU nurses’ live experience is scarcely known. This study aimed to describe the lived experience of intensive care unit nurses of caring for adult patients with a tracheostomy in intensive care unit. <b><p>Methods</b> This study ... -
A human adipose tissue cell-type transcriptome atlas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-12)The importance of defining cell-type-specific genes is well acknowledged. Technological advances facilitate high-resolution sequencing of single cells, but practical challenges remain. Adipose tissue is composed primarily of adipocytes, large buoyant cells requiring extensive, artefact-generating processing for separation and analysis. Thus, adipocyte data are frequently absent from single-cell ... -
The venous thrombosis registry in Østfold Hospital (TROLL registry) - design and cohort description
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-04)Purpose: The incidence of venous thromboembolism (VTE) is expected to increase over the next decades, further increasing its substantial impact on patients and health care resources. Registries have the benefit of reporting real-world data without excluding clinically important subgroups. Our aim was to describe a Norwegian VTE registry and to provide descriptive data on the population and ... -
Continuous Infusion of Iohexol to Monitor Perioperative Glomerular Filtration Rate
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-24)Continuous monitoring of the glomerular ltration rate (GFR) in the perioperative setting could provide valuable information about acute kidney injury risk for both clinical and research purposes. is pilot study aimed to demonstrate that GFR measurement by a continuous 72 hrs iohexol infusion in patients undergoing colorectal cancer surgery is feasible. Four patients undergoing robot-assisted ... -
Genomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-03)Orthopoxviruses (OPXVs) not only infect their natural hosts, but some OPXVs can also cause disease in humans. Previously, we partially characterized an OPXV isolated from an 18-year-old male living in Northern Norway. Restriction enzyme analysis and partial genome sequencing characterized this virus as an atypical cowpox virus (CPXV), which we named CPXV-No-H2. In this study, we determined the ... -
Incidence and Risk Factors of Pulmonary Hypertension After Venous Thromboembolism: An Analysis of a Large Health Care Database
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-15)Background<p> <p>Pulmonary hypertension (PH) is a devastating potential complication of pulmonary embolism, a manifestation of venous thromboembolism (VTE). The incidence of and risk factors for PH in those with prior VTE are poorly characterized. <p>Methods and Results <p>International Classification of Diseases (ICD) codes from inpatient and outpatient medical claims from MarketScan administrative ... -
Antibiotic treatment for appendicitis in Norway and Sweden: a nationwide survey on treatment practices
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-15)Background: Appendicitis is one of the most common causes of acute abdomen. Uncomplicated appendicitis is as an infamed appendix without perforation, gangrene or abscess formation. Recent trials show that one can safely treat uncomplicated appendicitis with antibiotics, given patient approval and appropriate follow-up. A recent study has also indicated no diference between antibiotic treatment ... -
Proteomics in thrombosis research
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-25)A State of the Art lecture titled “Proteomics in Thrombosis Research” was presented at the ISTH Congress in 2021. In clinical practice, there is a need for improved plasma biomarker-based tools for diagnosis and risk prediction of venous thromboembolism (VTE). Analysis of blood, to identify plasma proteins with potential utility for such tools, could enable an individualized approach to treatment ... -
Fødselsomsorgen kan bli bedre
(Journal article; Tidsskriftartikkel, 2022-04-27)Til tross for en god fødselsomsorg i Norge skjer det uønskede hendelser med alvorlig utfall for mor og/eller barn. I media kan man jevnlig lese om alvorlige hendelser i forbindelse med fødsel, der tema ofte er dødsfall eller skade som følge av manglende eller feil helsehjelp. Disse historiene gjør inntrykk.<p> <p>Det er ikke bare den berørte familien som blir hardt rammet, det er også de involverte ... -
Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health study in Tromsø, Norway. Participants with increased levels of anti-tissue transglutaminase-2 IgA ... -
Statistical analysis plan for the randomized controlled trial Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-19)Background: Patients with wake-up ischemic stroke are frequently excluded from thrombolytic treatment due to unknown symptom onset time and limited availability of advanced imaging modalities. The Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) is a randomized controlled trial of intravenous tenecteplase 0.25 mg/kg and standard care versus standard care alone (no thrombolysis) in patients ... -
mHealth interventions to reduce maternal and child mortality in Sub-Saharan Africa and Southern Asia: A systematic literature review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-25)Background: Reducing maternal mortality, neonatal mortality and under 5-year mortality are important targets addressed by the United Nations' Sustainable Development Goals. Despite studies reported an improvement in maternal and child health indicators, the progress achieved is not uniform across regions. Due to the increasing availability of mobile phones in low and middle-income countries, mHealth ... -
Assessing Trauma Management in Urban and Rural Populations in Norway: A National Register-Based Research Protocol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-17)Background: Time is considered an essential determinant in the initial care of trauma patients. In Norway, response time (ie, time from dispatch center call to ambulance arrival at scene) is a controversial national quality indicator. However, no national requirements for response times have been established. There is an ongoing debate regarding the optimal configuration of the Norwegian trauma ...
