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dc.contributor.authorAl-Nawas, Bilal
dc.contributor.authorLambert, France
dc.contributor.authorAndersen, Sanne Werner Møller
dc.contributor.authorBornstein, Michael M.
dc.contributor.authorGahlert, Michael
dc.contributor.authorJokstad, Asbjørn
dc.contributor.authorJung, Junho
dc.contributor.authorKwon, Yong-Dae
dc.contributor.authorLaleman, Isabelle
dc.contributor.authorOteri, Giacomo
dc.contributor.authorRoehling, Stefan
dc.contributor.authorSchiegnitz, Eik
dc.contributor.authorTakeda, Yukihiro
dc.contributor.authorTerheyden, Hendrik
dc.date.accessioned2023-12-22T09:56:53Z
dc.date.available2023-12-22T09:56:53Z
dc.date.issued2023-09-26
dc.description.abstractObjectives: The aim of Working Group 3 was to address the influence of both material- and anti-resorptive drug- related factors on clinical and biological outcomes and complications in implant dentistry. Focused questions were addressed on (a) implant materials other than titanium (alloy)s, (b) transmucosal abutment materials and (c) medications affecting bone metabolism were addressed.<p> <p>Materials and Methods: Three systematic reviews formed the basis for discussion in Group 3. Consensus statements and clinical recommendations were formulated by group consensus based on the findings of the systematic reviews. Patient perspectives and recommendations for future research were also conveyed. These were then presented and accepted following further discussion and modifications as required by the plenary. <p>Results: Zirconia is a valid alternative to titanium as material for implant and transmucosal components, allowing soft and hard tissue integration with clinical outcomes— identified by implant survival, marginal bone loss and peri-implant probing depths—up to 5-years comparable to titatnium. However, most of the evidence for zirconia implants is based on 1-piece implants limiting the indication range. Furthermore, based on expert opinion, zirconia transmucosal components might be preferred in the esthetic zone. In patients receiving low-dose bisphosphonate therapy, the rate of early implant failure is not increased, while the long-term effects remain poorly studied. Although it has not been sufficiently addressed, similar outcomes can be expected with low-dose denosumab. A drug holiday is not recommended when considering implant placement in patients treated with low-dose ARD. However, the specific therapeutic window, the cumulative dose and the administration time should be considered. Access to peri-implant supportive care is mandatory to prevent periimplantitis-related medication-related osteonecrosis of the jaw (MRONJ) or implantrelated sequestra (IRS). In patients receiving low-dose anti-resorptive drugs (ARD) therapy, the risk of complications related to implant placement is high, and implant procedures in this specific population should be strictly treated in a comprehensive multidisciplinary center. Finally, healthy dental implants should not be removed before low or high-dose ARD. <p>Conclusions: Zirconia implants can be an alternative to titanium implants in selected indications. However, the current state of evidence remains limited, especially for 2- piece implant designs. Administration of low-dose ARD did not show any negative impact on early implant outcomes, but careful follow-up and supportive care is recommended in order to prevent peri-implant MRONJ and IRS. Implant placement in high-dose patients must be strictly considered in a comprehensive multidisciplinary center.en_US
dc.identifier.citationAl-Nawas, Lambert, Andersen, Bornstein, Gahlert, Jokstad, Jung, Kwon, Laleman, Oteri, Roehling, Schiegnitz, Takeda, Terheyden. Group 3 ITI Consensus Report: Materials and antiresorptive drug-associated outcomes in implant dentistry. Clinical Oral Implants Research. 2023;34(26):169-176en_US
dc.identifier.cristinIDFRIDAID 2189286
dc.identifier.doi10.1111/clr.14135
dc.identifier.issn0905-7161
dc.identifier.issn1600-0501
dc.identifier.urihttps://hdl.handle.net/10037/32224
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalClinical Oral Implants Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleGroup 3 ITI Consensus Report: Materials and antiresorptive drug-associated outcomes in implant dentistryen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
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