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dc.contributor.advisorNymo, Siren
dc.contributor.advisorHansson, Patrik
dc.contributor.advisorIvan, Ingvild Hansen
dc.contributor.authorSandnes, Frida Huhta
dc.date.accessioned2024-05-13T11:59:22Z
dc.date.available2024-05-13T11:59:22Z
dc.date.issued2022-05-13en
dc.description.abstractBackground: Lipedema is an adipose tissue condition in females characterized by immobility, pain, and reduced quality of life (QoL). Recent publications indicate that ketogenic diets may induce symptom relief in women with lipedema. The aim of this study was to investigate the impact of a low-energy ketogenic diet on pain and QoL in women with lipedema, compared to a low-energy non-ketogenic diet. Methods: Adult females with lipedema and obesity were randomized to either a low-energy ketogenic diet (keto) or a low-energy non-ketogenic diet (control) for eight weeks. Pain was measured by Brief Pain Inventory, QoL by RAND-36, Impact of Weight on Quality of Life-lite, and Lymphoedema Quality of Life, at baseline and week 9. Results: 29 women with lipedema (age: 47 ± 11.2 years, body mass index 38.2 ± 5.5 kg/m2) were recruited to the study. The keto group achieved significant larger weight loss compared to the control group (-9.5 ± 1.4% vs. -7.1 ± 2.9%, p = 0.017, respectively). In the keto group only, there was a significant reduction in strongest pain (-2.0 ± 2.7, p = 0.020) and average pain (-1.8 ± 2.1, p = 0.016). Pain relief was not associated with weight loss in the keto group (r = -0.082, p = 0.801). Both the keto- and control-group improved total QoL (11.6 ± 6.3, p = 0.002 vs. 6.8 ± 10.4, p = 0.046, respectively), physical function (7.2 ± 5.7, p = 0.001 vs. 11.6 ± 18.5, p = 0.045), and energy (16.4 ± 20.5, p = 0.024 vs. 8.8 ± 8.6, p = 0.005). The keto group only, improved self-esteem (9.8 ± 13.3, p = 0.026). Conclusion: In this randomized controlled trial, a low-energy ketogenic diet induced pain relief and improved QoL. Larger clinical trials and longitudinal studies are needed to confirm these results and to explore underlying biological mechanisms.en_US
dc.identifier.urihttps://hdl.handle.net/10037/33519
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universitetno
dc.publisherUiT The Arctic University of Norwayen
dc.rights.holderCopyright 2022 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)en_US
dc.subject.courseIDERN-3900
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectVekttapen_US
dc.subjectWeight lossen_US
dc.subjectKetoseen_US
dc.subjectKetosisen_US
dc.subjectLavkalori dietten_US
dc.subjectLow-energy dietsen_US
dc.subjectSmerteen_US
dc.subjectPainen_US
dc.subjectLivskvaliteten_US
dc.subjectQuality of lifeen_US
dc.titleEffect of ketosis on pain and quality of life in women with lipedema.en_US
dc.typeMastergradsoppgaveno
dc.typeMaster thesisen


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Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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