Vis enkel innførsel

dc.contributor.advisorElin-Synnøve, Hadler-Olsen
dc.contributor.advisorAnna Maria, Wirsing
dc.contributor.authorAndersson Cronblad, Ida
dc.contributor.authorWarvik, Cathrine Elise
dc.contributor.authorBjerkli, Inger-Heidi
dc.contributor.authorEriksson Steigen, Sonja
dc.contributor.authorUhlin-Hansen, Lars
dc.contributor.authorMagnussen, Synnøve
dc.contributor.authorHadler-Olsen, Elin
dc.contributor.authorWirsing, Anna Maria
dc.date.accessioned2024-05-21T06:53:52Z
dc.date.available2024-05-21T06:53:52Z
dc.date.issued2022-05-21en
dc.description.abstractTumor lymphangiogenesis increases the area of interaction between lymphatic vessels and tumor cells, and may thereby facilitate metastases. In oral cancer high lymphatic vessel density (LVD) and large lymphatic vessel area (LVA) have been associated with more aggressive tumors, but results from different studies are not conclusive. The aim of this study was to assess the association of tumor-associated LVD and LVA with clinical-pathological data, including patient survival, in a homogenous cohort of oral tongue squamous cell carcinoma (OTSCC) patients. Formalin-fixed, paraffin-embedded tumour samples from 125 OTSCC patients were immunohistochemically stained with the D2-40 antibody to recognize lymphatic vessels. The mean LVD and the mean LVA were analysed in five hotspots per tumour sample and compared to clinical-pathological data as well as 5-year disease-specific survival (DSS). Neither LVD nor LVA were significantly associated with the clinical-pathological variables or 5-year DSS in our patient cohort. In univariate analyses, the N status, tumour stage, tumour differentiation as well as lymphocyte infiltration were the only significant predictors for patient outcome (p<0.001, p<0.001, p<0.001 and p=0.043 respectively). In multivariate analyses, only the N status and tumour differentiation were independent prognostic factors. LVD and LVA are not indicative of 5-year DSS in our OTSCC cohort. More studies on the immunoregulatory, location-dependent role of lymphatic vessels in large, homogeneous OTSCC patient cohorts are needed.en_US
dc.identifier.urihttps://hdl.handle.net/10037/33575
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universitetno
dc.publisherUiT The Arctic University of Norwayen
dc.rights.holderCopyright 2022 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)en_US
dc.subject.courseIDMED-3910
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Generell patologi, patologisk anatomi: 719en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830::Oral medisin: 835en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830::Oral medisin: 835en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830::Oral kirurgi: 835en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830::Oral medisin: 835en_US
dc.titleCharacterization and prognostic value of lymphatic vessels in an oral tongue squamous cell carcinoma cohorten_US
dc.typeMastergradsoppgaveno
dc.typeMaster thesisen


Tilhørende fil(er)

Thumbnail
Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)