Institutt for medisinsk biologi: Nye registreringer

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    • Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines 

      von Hofsten, Susannah; Langer, Manuel K; Korelin, Katja; Norvoll Magnussen, Synnøve; Ausbacher, Dominik; Anderssen, Trude; Salo, Tuula; Strøm, Morten B.; Bayer, Annette; Al-Samadi, Ahmed; Berge, gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-30)
      The incidence of head and neck squamous cell carcinoma (HNSCC) is increasing and the conventional treatments for this form of cancer can be tough. Despite the success of existing immunotherapies in some HNSCC patients, many do not respond to this type of treatment. Thus, the development of novel anti-cancer therapies should be prioritized. In the current study, the anticancer activity of a panel ...

    • SIRT1 - a new mammalian substrate of nuclear autophagy 

      Wang, Lu; Xu, Caiyue; Johansen, Terje; Berger, Shelley L.; Dou, Zhixun (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-20)
      Macroautophagic/autophagic degradation of nuclear components (or nuclear autophagy) is a poorly understood area in autophagy research. We previously reported the nuclear lamina protein LMNB1 (lamin B1) as a nuclear autophagy substrate in primary human cells, stimulating the investigation of nuclear autophagy in the mammalian system. We recently reported the sirtuin protein SIRT1 as a new selective ...

    • A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation 

      Aarhus, Thomas Ihle; Eickhoff, Jan; Klebl, Bert; Unger, Anke; Boros, Johanna; Choidas, Axel; Zischinsky, Mia-Lisa; Wolowczyk, Camilla Izabel; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)
      The colony-stimulating factor 1 receptor (CSF1R) plays an important role in the regulation of many inflammatory processes, and overexpression of the kinase is implicated in several disease states. Identifying selective, smallmolecule inhibitors of CSF1R may be a crucial step toward treating these disorders. Through modelling, synthesis, and a systematic structure-activity relationship study, we ...

    • SIRT1 is downregulated by autophagy in senescence and ageing 

      Xu, Caiyue; Wang, Lu; Fozouni, Parinaz; Evjen, Gry; Chandra, Vemika; Jiang, Jing; Lu, Congcong; Nicastri, Michael; Bretz, Corey; Winkler, Jeffrey D.; Amaravadi, Ravi; Garcia, Benjamin A.; Adams, Peter D.; Ott, Melanie; Tong, Wei; Johansen, Terje; Dou, Zhixun; Berger, Shelley L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-28)
      SIRT1 (Sir2) is an NAD<sup>+</sup>-dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, the immune response and ageing<sup>1,2,3,4,5</sup>. Although there is strong interest in stimulating SIRT1 catalytic activity, the homeostasis of SIRT1 at the protein level is poorly understood. Here we report that macroautophagy (hereafter referred to as ...

    • Nytt håp for voksne leukemipasienter 

      Arranz, Lorena; Juul, Kjersti (Chronicle; Kronikk, 2023-04-11)
      Norske forskere er i ferd med å utvikle en behandling som øker overlevelsen for voksne leukemipasienter.

    • Mikrobiologisk beredskap: Strategimøte nr 19, 2005 

      Lassen, Jørgen; Sandven, Per; Hjertland, Reidar; Mannsåker, Turid; Myrmel, Helge; Simonsen, Gunnar Skov (Research report; Forskningsrapport, 2005)
      Referansegruppen for programmet ”Eksterne kvalitetsvurderinger i bakteriologi, mykologi og parasittologi” arrangerte 04.11.2005 det 19. strategimøtet for programmets deltagere. Møtets tema var denne gangen ”Mikrobiologisk beredskap”.

    • TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1 

      Zhou, Jianwen; Rasmussen, Nikoline Lander; Olsvik, Hallvard Lauritz; Akimov, Vyacheslav; Hu, Zehan; Evjen, Gry; Kaeser-Pebernard, Stéphanie; Sankar, Devanarayanan Siva; Roubaty, Carole; Verlhac, Pauline; van de Beck, Nicole; Reggiori, Fulvio; Abudu, Yakubu Princely; Blagoev, Blagoy; Lamark, Trond; Johansen, Terje; Dengjel, Jörn (Journal article; Tidsskriftartikkel, 2022-12-27)
      Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in promoting the establishment of a robust inflammatory response. Under inflammatory conditions, here TLR3-activation by poly(I:C) treatment, the inflammation ...

    • No Effect of Calanus Oil on Maximal Oxygen Uptake in Healthy Participants: A Randomized Controlled Study 

      Tauschek, Lucas Christian; Røsbjørgen, Ragnhild; Dalen, Håvard; Larsen, Terje; Karlsen, Trine (Journal article; Tidsskriftartikkel, 2022-08-23)
      We aimed to investigate the long-term effect of daily Calanus oil supplementation on maximal oxygen uptake (VO<sub>2</sub>max) in healthy 30- to 50-year-old participants. The study was motivated by preclinical studies reporting increased VO<sub>2</sub>max and metabolic health with omega-3 rich Calanus oil. In a double-blinded study, 71 participants were randomized to receive 2 g/day of Calanus or ...

    • High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis 

      Bitossi, Camilla; Viscido, Agnese; Prezioso, Carla; Brazzini, Gabriele; Trancassini, Maria; Borrazzo, Cristian; Passerini, Sara; Frasca, Federica; Scordio, Mirko; Sorrentino, Leonardo; Oliveto, Giuseppe; Fracella, Matteo; D'Auria, Alessandra; Selvaggi, Carla; Cimino, Giuseppe; Midulla, Fabio; Pierangeli, Alessandra; Antonelli, Guido; Moens, Ugo Lionel; Pietropaolo, Valeria; Scagnolari, Carolina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)
      Merkel cell polyomavirus (MCPyV) has been detected in respiratory specimens including those from Cystic Fibrosis (CF) patients, raising questions about its immunological and clinical relevance in the respiratory tract. MCPyV might promote an inappropriate antiviral response contributing to a chronic inflammatory response and resulting in detrimental effects in CF. Respiratory samples (n = 1138) were ...

    • Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage 

      Jia, Jingyue; Wang, Fulong; Bhujabal, Zambarlal Babanrao; Peters, Ryan; Mudd, Michal; Duque, Thabata; Allers, Lee; Javed, Ruheena; Salemi, Michelle; Behrends, Christian; Phinney, Brett; Johansen, Terje; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-29)
      The functions of mammalian Atg8 proteins (mATG8s) expand beyond canonical autophagy and include processes collectively referred to as Atg8ylation. Global modulation of protein synthesis under stress conditions is governed by MTOR and liquid-liquid phase separated condensates containing ribonucleoprotein particles known as stress granules (SGs). We report that lysosomal damage induces SGs acting as ...

    • Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage 

      Jia, Jingyue; Wang, Fulong; Bhujabal, Zambarlal Babanrao; Peters, Ryan; Mudd, Michal; Duque, Thabata; Allers, Lee; Javed, Ruheena; Salemi, Michelle; Behrends, Christian; Phinney, Brett; Johansen, Terje; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosomedamaging agents including SARS-CoV-2ORF3a, Mycobacterium tuberculosis, and proteopathic tau. During damage, mammalian ATG8s directly interacted with the ...

    • Transiently silent acquired antimicrobial resistance: an emerging challenge in susceptibility testing 

      Wagner, Theresa; Howden, Benjamin P; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-31)
      Acquisition and expression of antimicrobial resistance (AMR) mechanisms in bacteria are often associated with a fitness cost. Thus, evolutionary adaptation and fitness cost compensation may support the advance of subpopulations with a silent resistance phenotype when the antibiotic selection pressure is absent. However, reports are emerging on the transient nature of silent acquired AMR, describing ...

    • Proposal of selective inhibitor for bacterial zinc metalloprotease: Molecular mechanics and ab initio molecular orbital calculations 

      Imai, Kyohei; Saito, Rysouke; Ezawa, Takyua; Sugiyama, Satoshi; Sylte, Ingebrigt; Kurita, Noriyuki (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-11)
      The zinc metalloprotease pseudolysin (PLN) secreted from Pseudomonas aeruginosa degrades extracellular proteins to produce bacterial nutrition, and various types of PLN inhibitors have been developed to suppress the bacterial growth. However, as the structure of the ligand-binding pocket of PLN has large similarities to those of human matrix metalloproteinases (MMPs) and other human zinc metalloprotease, ...

    • Health and diseases of semi-domesticated reindeer in a climate change perspective 

      Tryland, Morten; Åhman, Birgitta; Sanchez Romano, Javier (Chapter; Bokkapittel, 2022-04-21)
      Climate change may affect reindeer herding and the health and disease of reindeer in several ways. One way of mitigating such changes is supplementary feeding, both in corrals and by bringing fodder to the animals on natural pastures. Feeding, when the right feed and feeding regime are used, may compensate for the loss of natural pastures and increase animal welfare. However, feeding may also cause ...

    • Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia 

      Cai, Jiazheng; Liu, Jing; Yan, Jing; Lu, Xuexia; Wang, Xiaoli; Li, Si; Mustafa, Kamal Babikeir Elnour; Wang, Huihui; Xue, Ying; Mustafa, Manal; Kantarci, Alpdogan; Xing, Zhe (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)
      Objective - Periodontal ligament cells (PDLCs) are critical for wound healing and regenerative capacity of periodontal diseases. Within an inflammatory periodontal pocket, a hypoxic environment can aggravate periodontal inflammation, where PDLCs response to the inflammation would change. Resolvin D1 (RvD1) is an endogenous lipid mediator, which can impact intracellular inflammatory pathways of ...

    • Correlation of expression of Major Vault Protein with androgen receptor and immune checkpoint protein B7-H3, and with poor prognosis in prostate cancer 

      Nunes-Xavier, Caroline Elisabeth; Emaldi, Maite; Guldvik, Ingrid Jenny; Ramberg, Håkon; Tasken, Kristin Austlid; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Llarena, Roberto; Pulido, Rafael; Lopez, José I. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-24)
      Prostate cancer diagnosis and early stratification is an important aspect to avoid undertreatment of high-risk prostate cancer patients. Major Vault Protein (MVP) has been proposed as a prognostic biomarker in prostate cancer. PTEN and the immune checkpoint protein B7-H3 interact with MVP and are important in prostate cancer progression and therapy response. We evaluated the expression of MVP by ...

    • The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy 

      Berge, Anne Kristin McLaren; Garcia, Juncal Garcia; Sjøttem, Eva; Olsvik, Hallvard Lauritz (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-05)
      Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health. Failure of these control mechanisms may lead to damaged mitochondria that represent a threat to cell survival. Mitophagy is a selective autophagy process that removes damaged mitochondria ...

    • NBR1: The archetypal selective autophagy receptor 

      Rasmussen, Nikoline Lander; Kournoutis, Athanasios; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-18)
      NBR1 was discovered as an autophagy receptor not long after the first described vertebrate autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while NBR1 is mentioned in <350 papers. Nonetheless, evolutionary analysis reveals that NBR1, and likely also selective autophagy, was present already in the last eukaryotic common ancestor (LECA), while ...

    • The effect of resolvin D1 on bone regeneration in a rat calvarial defect model 

      Jiang, Xiaofeng; Liu, Jing; Li, Si; Qiu, Yingfei; Wang, Xiaoli; He, Xiaoli; Pedersen, Torbjørn Østvik; Mustafa, Kamal Babikeir Elnour; Xue, Ying; Mustafa, Manal; Kantarci, Alpdogan; Xing, Zhe (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-18)
      Resolvin D1 (RvD1) is a pro-resolving lipid mediator of inflammation, endogenously synthesized from omega-3 docosahexaenoic acid. The purpose of this study was to investigate the effect of RvD1 on bone regeneration using a rat calvarial defect model. Collagen 3D nanopore scaffold (COL) and Pluronic F127 hydrogel (F127) incorporated with RvD1 (RvD1-COL-F127 group) or COL and F127 (COL-F127 group) ...

    • Association between copy number variations in the OCA2-HERC2 locus and human eye colour 

      Salvo, Nina Mjølsnes; Janssen, Kirstin; Olsen, Gunn-Hege; Berg, Thomas; Andersen, Jeppe Dyrberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-29)
      Human eye colour variation is strongly associated with single nucleotide polymorphisms (SNPs) in the OCA2- HERC2 locus, especially rs12913832 that is found in an enhancer element of OCA2. In a previous study we found that 43 out of 166 individuals in a Norwegian population with the brown eye colour genotype HERC2 rs12913832:AA or AG, did not have the expected brown eye colour. To investigate if ...