Aim - To assess the relationship between periodontitis and experimental pain tolerance.<p> <p>Materials and Methods - Participants from the population-based seventh survey of the Tromsø Study with data on periodontitis were included (n = 3666, 40–84 years old, 51.6% women). Pain tolerance was assessed through (i) pressure pain tolerance (PPT) test with a computerized cuff pressure algometry on ...

The human polyomavirus BKPyV infects most people worldwide and establishes a lifelong persistent infection in the renourinary tract. The virus rarely gives symptoms in healthy people, but it can cause severe disease under certain immunocompromised states. Despite its high prevalence, our knowledge about how the virus evades host immunity and persists still poor. Extracellular vesicles (EVs) ...

Klebsiella pneumoniae species complex (KpSC) is a group of closely related bacterial species including Klebsiella pneumoniae sensu stricto known as a major human opportunistic pathogen associated with healthcare. KpSC gut carriage is a major risk factor for clinical infections and elderly people (≥60y) are at the risk of KpSC gut colonisation. This master project investigated the presence, duration ...

Background of the study: Cancer-associated fibroblasts (CAFs) are a heterogeneous population of cells that are mainly found in solid malignancies and play vital roles in tumor progression and metastasis, including important immunoregulatory functions. In this study, our objective was to explore the immunosuppressive adenosine system within the CAFs isolated from non-small cell lung carcinomas (NSCLC) ...

The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the structural and functional features of Atg8 family proteins and their protein-protein interaction modes in model organisms such as yeast, Arabidopsis, ...

En forskningsgruppe ved UiT samler inn avføring fra barn og unge for å studere tarmbakterier. Målet er å utvikle bedre diagnoser for sykdommer og oppdage lidelser tidligere, ifølge medisinstudent Ole Martin Ellingsbø Nilsen. Prosjektet har fått økonomisk støtte fra Barnekreftforeningen og rekrutteringshjelp fra Tromsø kommune. Ungdommer som deltar får en «kit» for å samle inn prøvene, samt ...

Membrane transporter proteins are divided into channels/pores and carriers and constitute protein families of physiological and pharmacological importance. Several presently used therapeutic compounds elucidate their effects by targeting membrane transporter proteins, including anti-arrhythmic, anesthetic, antidepressant, anxiolytic and diuretic drugs. The lack of three-dimensional structures of ...

The development of new treatment options for bacterial infections requires access to new targets for antibiotics and antivirulence strategies. Chemoproteomic approaches are powerful tools for profiling and identifying novel druggable target candidates, but their functions often remain uncharacterized. Previously, we used activity-based protein profiling in the opportunistic pathogen Staphylococcus ...

Objectives - We aimed to characterize the vanE cluster and its genetic support in the first Norwegian vanE-type isolates and assess genetic relatedness to other vanE isolates.<p> <p>Methods - Two vanE-type vancomycin resistant Enterococcus faecalis (vanE-VREfs) isolates (E1 and E2) recovered from the same patient 30 months apart were examined for antimicrobial susceptibility, genome sequence, ...

In super-resolution structured illumination microscopy (SR-SIM) the separation between opposing laser spots in the back focal plane of the objective lens affects the pattern periodicity, and, thus, the resulting spatial resolution. Here, we introduce a novel hexagonal prism telescope which allows us to seamlessly change the separation between parallel laser beams for 3 pairs of beams, simultaneously. ...