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dc.contributor.authorCetrelli, Lena Elisabet
dc.contributor.authorLundestad, Anette
dc.contributor.authorGil, Elisabeth Grut
dc.contributor.authorFischer, Johannes Maria
dc.contributor.authorHalbig, Josefine Mareile
dc.contributor.authorFrid, Paula Hanna Therese
dc.contributor.authorAngenete, Oskar W
dc.contributor.authorRosén, Annika
dc.contributor.authorTylleskär, Karin Birgitta
dc.contributor.authorLuukko, Keijo
dc.contributor.authorNordal, Ellen Berit
dc.contributor.authorÅstrøm, Anne-Kristine N
dc.contributor.authorSkeie, Marit Slåttelid
dc.contributor.authorStunes, Astrid Kamilla
dc.contributor.authorBletsa, Athanasia
dc.contributor.authorSen, Abhijit
dc.contributor.authorFeuerherm, Astrid Jullumstrø
dc.contributor.authorRygg, Marite
dc.date.accessioned2024-08-22T07:46:22Z
dc.date.available2024-08-22T07:46:22Z
dc.date.issued2024-03-09
dc.description.abstractBackground - Biomarkers may be useful in monitoring disease activity in juvenile idiopathic arthritis (JIA). With new treatment options and treatment goals in JIA, there is an urgent need for more sensitive and responsive biomarkers.<p> <p>Objective - We aimed to investigate the patterns of 92 inflammation-related biomarkers in serum and saliva in a group of Norwegian children and adolescents with JIA and controls and in active and inactive JIA. In addition, we explored whether treatment with tumor necrosis factor inhibitors (TNFi) affected the biomarker levels.<p> <p>Methods - This explorative, cross-sectional study comprised a subset of children and adolescents with non-systemic JIA and matched controls from the Norwegian juvenile idiopathic arthritis study (NorJIA Study). The JIA group included individuals with clinically active or inactive JIA. Serum and unstimulated saliva were analyzed using a multiplex assay of 92 inflammation-related biomarkers. Welch’s t-test and Mann–Whitney U-test were used to analyze the differences in biomarker levels between JIA and controls and between active and inactive disease.<p> <p>Results - We included 42 participants with JIA and 30 controls, predominantly females, with a median age of 14 years. Of the 92 biomarkers, 87 were detected in serum, 73 in saliva, and 71 in both biofluids. A pronounced difference between serum and salivary biomarker patterns was found. Most biomarkers had higher levels in serum and lower levels in saliva in JIA versus controls, and in active versus inactive disease. In serum, TNF and S100A12 levels were notably higher in JIA and active disease. The TNF increase was less pronounced when excluding TNFi-treated individuals. In saliva, several biomarkers from the chemokine family were distinctly lower in the JIA group, and levels were even lower in active disease.<p> <p>Conclusion - In this explorative study, the serum and salivary biomarker patterns differed markedly, suggesting that saliva may not be a suitable substitute for serum when assessing systemic inflammation in JIA. Increased TNF levels in serum may not be a reliable biomarker for inflammatory activity in TNFi-treated children and adolescents with JIA. The lower levels of chemokines in saliva in JIA compared to controls and in active compared to inactive disease, warrant further investigation.en_US
dc.identifier.citationCetrelli, Lundestad, Gil, Fischer, Halbig, Frid, Angenete, Rosén, Tylleskär, Luukko, Nordal, Åstrøm, Skeie, Stunes, Bletsa, Sen, Feuerherm, Rygg. Serum and salivary inflammatory biomarkers in juvenile idiopathic arthritis—an explorative cross-sectional study. Pediatric Rheumatology. 2024;22(1)en_US
dc.identifier.cristinIDFRIDAID 2257951
dc.identifier.doi10.1186/s12969-024-00972-6
dc.identifier.issn1546-0096
dc.identifier.urihttps://hdl.handle.net/10037/34348
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalPediatric Rheumatology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleSerum and salivary inflammatory biomarkers in juvenile idiopathic arthritis—an explorative cross-sectional studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)